Imperial College London

DrIanMaconochie

Faculty of MedicineSchool of Public Health

Professor of Practice (Paediatric Emergency Medicine)
 
 
 
//

Contact

 

+44 (0)20 3312 3729i.maconochie

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Wang:2019:10.1038/s41598-019-53721-1,
author = {Wang, X and Nijman, R and Camuzeaux, S and Sands, C and Jackson, H and Kaforou, M and Emonts, M and Herberg, JA and Maconochie, I and Carrol, ED and Paulus, SC and Zenz, W and Van, der Flier M and de, Groot R and Martinon-Torres, F and Schlapbach, LJ and Pollard, AJ and Fink, C and Kuijpers, TT and Anderson, S and Lewis, MR and Levin, M and McClure, M and EUCLIDS, consortium},
doi = {10.1038/s41598-019-53721-1},
journal = {Sci Rep},
title = {Plasma lipid profiles discriminate bacterial from viral infection in febrile children.},
url = {http://dx.doi.org/10.1038/s41598-019-53721-1},
volume = {9},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Fever is the most common reason that children present to Emergency Departments. Clinical signs and symptoms suggestive of bacterial infection are often non-specific, and there is no definitive test for the accurate diagnosis of infection. The 'omics' approaches to identifying biomarkers from the host-response to bacterial infection are promising. In this study, lipidomic analysis was carried out with plasma samples obtained from febrile children with confirmed bacterial infection (n = 20) and confirmed viral infection (n = 20). We show for the first time that bacterial and viral infection produces distinct profile in the host lipidome. Some species of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were higher in the confirmed virus infected group, while some species of fatty acids, glycerophosphocholine, glycerophosphoserine, lactosylceramide and bilirubin were lower in the confirmed virus infected group when compared with confirmed bacterial infected group. A combination of three lipids achieved an area under the receiver operating characteristic (ROC) curve of 0.911 (95% CI 0.81 to 0.98). This pilot study demonstrates the potential of metabolic biomarkers to assist clinicians in distinguishing bacterial from viral infection in febrile children, to facilitate effective clinical management and to the limit inappropriate use of antibiotics.
AU - Wang,X
AU - Nijman,R
AU - Camuzeaux,S
AU - Sands,C
AU - Jackson,H
AU - Kaforou,M
AU - Emonts,M
AU - Herberg,JA
AU - Maconochie,I
AU - Carrol,ED
AU - Paulus,SC
AU - Zenz,W
AU - Van,der Flier M
AU - de,Groot R
AU - Martinon-Torres,F
AU - Schlapbach,LJ
AU - Pollard,AJ
AU - Fink,C
AU - Kuijpers,TT
AU - Anderson,S
AU - Lewis,MR
AU - Levin,M
AU - McClure,M
AU - EUCLIDS,consortium
DO - 10.1038/s41598-019-53721-1
PY - 2019///
TI - Plasma lipid profiles discriminate bacterial from viral infection in febrile children.
T2 - Sci Rep
UR - http://dx.doi.org/10.1038/s41598-019-53721-1
UR - https://www.ncbi.nlm.nih.gov/pubmed/31776453
UR - http://hdl.handle.net/10044/1/74859
VL - 9
ER -