Imperial College London
Dr Ian Maconochie

DrIanMaconochie

Faculty of Medicine, Department of Infectious Disease

Professor of Practice (Paediatric Emergency Medicine)
 
 
 
//

Contact

 

+44 (0)20 3312 3729i.maconochie

 
 
//

Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Ahmad:2018:10.1007/s10439-018-2089-4,
author = {Ahmad, F and Soe, S and White, N and Johnston, R and Khan, I and Liao, J and Jones, M and Prabhu, R and Maconochie, I and Theobald, P},
doi = {10.1007/s10439-018-2089-4},
journal = {Annals of Biomedical Engineering},
pages = {2162--2176},
title = {Region-specific microstructure in the neonatal ventricles of a porcine model},
url = {http://dx.doi.org/10.1007/s10439-018-2089-4},
volume = {46},
year = {2018}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The neonate transitions from placenta-derived oxygen, to supply from the pulmonary system, moments after birth. This requires a series of structural developments to divert more blood through the right heart and onto the lungs, with the tissue quickly remodelling to the changing ventricular workload. In some cases, however, the heart structure does not fully develop causing poor circulation and inefficient oxygenation, which is associated with an increase in mortality and morbidity. This study focuses on developing an enhanced knowledge of the 1-day old heart, quantifying the region-specific microstructural parameters of the tissue. This will enable more accurate mathematical and computational simulations of the young heart. Hearts were dissected from 12, 1-day-old deceased Yorkshire piglets (mass: 2.1–2.4 kg, length: 0.38–0.51 m), acquired from a breeding farm. Evans blue dye was used to label the heart equator and to demarcate the left and right ventricle free walls. Two hearts were used for three-dimensional diffusion-tensor magnetic resonance imaging, to quantify the fractional anisotropy (FA). The remaining hearts were used for two-photon excited fluorescence and second-harmonic generation microscopy, to quantify the cardiomyocyte and collagen fibril structures within the anterior and posterior aspects of the right and left ventricles. FA varied significantly across both ventricles, with the greatest in the equatorial region, followed by the base and apex. The FA in each right ventricular region was statistically greater than that in the left. Cardiomyocyte and collagen fibre rotation was greatest in the anterior wall of both ventricles, with less dispersion when compared to the posterior walls. In defining these key parameters, this study provides a valuable insight into the 1-day-old heart that will provide a valuable platform for further investigation the normal and abnormal heart using mathematical and computational models.
AU  - Ahmad,F
AU  - Soe,S
AU  - White,N
AU  - Johnston,R
AU  - Khan,I
AU  - Liao,J
AU  - Jones,M
AU  - Prabhu,R
AU  - Maconochie,I
AU  - Theobald,P
DO  - 10.1007/s10439-018-2089-4
EP  - 2176
PY  - 2018///
SN  - 0090-6964
SP  - 2162
TI  - Region-specific microstructure in the neonatal ventricles of a porcine model
T2  - Annals of Biomedical Engineering
UR  - http://dx.doi.org/10.1007/s10439-018-2089-4
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000451997300018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/65474
VL  - 46
ER  -
Download