Imperial College London
Dr Ian Maconochie

DrIanMaconochie

Faculty of Medicine, Department of Infectious Disease

Professor of Practice (Paediatric Emergency Medicine)
 
 
 
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Contact

 

+44 (0)20 3312 3729i.maconochie

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ahmad:2018:10.1016/j.jmbbm.2018.07.038,
author = {Ahmad, F and Prabhu, R and Liao, J and Soe, S and Jones, MD and Miller, J and Berthelson, P and Enge, D and Copeland, KM and Shaabeth, S and Johnston, R and Maconochie, I and Theobald, PS},
doi = {10.1016/j.jmbbm.2018.07.038},
journal = {Journal of the Mechanical Behavior of Biomedical Materials},
pages = {18--28},
title = {Biomechanical properties and microstructure of neonatal porcine ventricles},
url = {http://dx.doi.org/10.1016/j.jmbbm.2018.07.038},
volume = {88},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Neonatal heart disorders represent a major clinical challenge, with congenital heart disease alone affecting 36,000 new-borns annually within the European Union. Surgical intervention to restore normal function includes the implantation of synthetic and biological materials; however, a lack of experimental data describing the mechanical behaviour of neonatal cardiac tissue is likely to contribute to the relatively poor short- and long-term outcome of these implants. This study focused on characterising the mechanical behaviour of neonatal cardiac tissue using a porcine model, to enhance the understanding of how this differs to the equivalent mature tissue. The biomechanical properties of neonatal porcine cardiac tissue were characterised by uniaxial tensile, biaxial tensile, and simple shear loading modes, using samples collected from the anterior and posterior walls of the right and left ventricles. Histological images were prepared using Masson’s trichrome staining, to enable assessment of the microstructure and correlation with tissue behaviour. The mechanical tests demonstrated that the neonatal cardiac tissue is non–linear, anisotropic, viscoelastic and heterogeneous. Our data provide a baseline describing the biomechanical behaviour of immature porcine cardiac tissue. Comparison with published data also indicated that the neonatal porcine cardiac tissue exhibits one-half the stiffness of mature porcine tissue in uniaxial extension testing, one-third in biaxial extension testing, and one-fourth stiffness in simple shear testing; hence, it provides an indication as to the relative change in characteristics associated with tissue maturation. These data may prove valuable to researchers investigating neonatal cardiac mechanics.
AU  - Ahmad,F
AU  - Prabhu,R
AU  - Liao,J
AU  - Soe,S
AU  - Jones,MD
AU  - Miller,J
AU  - Berthelson,P
AU  - Enge,D
AU  - Copeland,KM
AU  - Shaabeth,S
AU  - Johnston,R
AU  - Maconochie,I
AU  - Theobald,PS
DO  - 10.1016/j.jmbbm.2018.07.038
EP  - 28
PY  - 2018///
SN  - 1751-6161
SP  - 18
TI  - Biomechanical properties and microstructure of neonatal porcine ventricles
T2  - Journal of the Mechanical Behavior of Biomedical Materials
UR  - http://dx.doi.org/10.1016/j.jmbbm.2018.07.038
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448090700003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/66632
VL  - 88
ER  -
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