Imperial College London

Professor Irene Miguel-Aliaga

Faculty of MedicineInstitute of Clinical Sciences

Professor of Genetics and Physiology
 
 
 
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Contact

 

+44 (0)20 3383 3907i.miguel-aliaga Website

 
 
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Location

 

232ICTEM buildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
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40 results found

Miguel-Aliaga I, 2017, Irene Miguel-Aliaga, CURRENT BIOLOGY, Vol: 27, Pages: R286-R287, ISSN: 0960-9822

JOURNAL ARTICLE

Miguel-Aliaga I, 2017, Sex, Reproduction and Intestinal Plasticity, 18th International Congress of Developmental Biology, Publisher: ELSEVIER SCIENCE BV, Pages: S5-S5, ISSN: 0925-4773

CONFERENCE PAPER

Perea D, Guiu J, Hudry B, Konstantinidou C, Milona A, Hadjieconomou D, Carroll T, Hoyer N, Natarajan D, Kallijarvi J, Walker JA, Soba P, Thapar N, Burns AJ, Jensen KB, Miguel-Aliaga Iet al., 2017, Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia, EMBO JOURNAL, Vol: 36, Pages: 3029-3045, ISSN: 0261-4189

JOURNAL ARTICLE

Hudry B, Khadayate S, Miguel-Aliaga I, 2016, The sexual identity of adult intestinal stem cells controls organ size and plasticity, NATURE, Vol: 530, Pages: 344-+, ISSN: 0028-0836

JOURNAL ARTICLE

Miguel-Aliaga I, 2015, Cell scientist to watch - Irene Miguel-Aliaga, JOURNAL OF CELL SCIENCE, Vol: 128, Pages: 3519-3520, ISSN: 0021-9533

JOURNAL ARTICLE

Reiff T, Jacobson J, Cognigni P, Antonello Z, Ballesta E, Tan KJ, Yew JY, Dominguez M, Miguel-Aliaga Iet al., 2015, Endocrine remodelling of the adult intestine sustains reproduction in Drosophila., eLife, Vol: 4, ISSN: 2050-084X

The production of offspring is energetically costly and relies on incompletely understood mechanisms that generate a positive energy balance. In mothers of many species, changes in key energy-associated internal organs are common yet poorly characterised functionally and mechanistically. In this study, we show that, in adult Drosophila females, the midgut is dramatically remodelled to enhance reproductive output. In contrast to extant models, organ remodelling does not occur in response to increased nutrient intake and/or offspring demands, but rather precedes them. With spatially and temporally directed manipulations, we identify juvenile hormone (JH) as an anticipatory endocrine signal released after mating. Acting through intestinal bHLH-PAS domain proteins Methoprene-tolerant (Met) and Germ cell-expressed (Gce), JH signals directly to intestinal progenitors to yield a larger organ, and adjusts gene expression and sterol regulatory element-binding protein (SREBP) activity in enterocytes to support increased lipid metabolism. Our findings identify a metabolically significant paradigm of adult somatic organ remodelling linking hormonal signals, epithelial plasticity, and reproductive output.

JOURNAL ARTICLE

Soba P, Han C, Zheng Y, Perea D, Miguel-Aliaga I, Jan LY, Jan YNet al., 2015, The Ret receptor regulates sensory neuron dendrite growth and integrin mediated adhesion, eLife, Vol: 4, ISSN: 2050-084X

JOURNAL ARTICLE

Linneweber GA, Jacobson J, Busch KE, Hudry B, Christov CP, Dormann D, Yuan M, Otani T, Knust E, de Bono M, Miguel-Aliaga Iet al., 2014, Neuronal Control of Metabolism through Nutrient-Dependent Modulation of Tracheal Branching, CELL, Vol: 156, Pages: 69-83, ISSN: 0092-8674

JOURNAL ARTICLE

Martorell O, Merlos-Suarez A, Campbell K, Barriga FM, Christov CP, Miguel-Aliaga I, Batlle E, Casanova J, Casali Aet al., 2014, Conserved Mechanisms of Tumorigenesis in the Drosophila Adult Midgut, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

Wayland MT, Defaye A, Rocha J, Jayaram SA, Royet J, Miguel-Aliaga I, Leulier F, Cognigni Pet al., 2014, Spotting the differences: Probing host/microbiota interactions with a dedicated software tool for the analysis of faecal outputs in Drosophila, JOURNAL OF INSECT PHYSIOLOGY, Vol: 69, Pages: 126-135, ISSN: 0022-1910

JOURNAL ARTICLE

Lemaitre B, Miguel-Aliaga I, 2013, The Digestive Tract of Drosophila melanogaster, ANNUAL REVIEW OF GENETICS, VOL 47, Vol: 47, Pages: 377-404, ISSN: 0066-4197

JOURNAL ARTICLE

Sarraf-Zadeh L, Christen S, Sauer U, Cognigni P, Miguel-Aliaga I, Stocker H, Koehler K, Hafen Eet al., 2013, Local requirement of the Drosophila insulin binding protein imp-L2 in coordinating developmental progression with nutritional conditions, DEVELOPMENTAL BIOLOGY, Vol: 381, Pages: 97-106, ISSN: 0012-1606

JOURNAL ARTICLE

Cognigni P, Bailey AP, Miguel-Aliaga I, 2012, Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis (vol 13, pg 104, 2011), CELL METABOLISM, Vol: 15, Pages: 128-128, ISSN: 1550-4131

JOURNAL ARTICLE

Miguel-Aliaga I, 2012, Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans, SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, Vol: 23, Pages: 614-620, ISSN: 1084-9521

JOURNAL ARTICLE

Miguel-Aliaga I, Oliver B, Teleman AA, 2012, The flies of Icarus: science with wings in Crete, EMBO REPORTS, Vol: 13, Pages: 945-947, ISSN: 1469-221X

JOURNAL ARTICLE

Oyallon J, Apitz H, Miguel-Aliaga I, Timofeev K, Ferreira L, Salecker Iet al., 2012, Regulation of locomotion and motoneuron trajectory selection and targeting by the Drosophila homolog of Olig family transcription factors, DEVELOPMENTAL BIOLOGY, Vol: 369, Pages: 261-276, ISSN: 0012-1606

JOURNAL ARTICLE

Talsma AD, Christov CP, Terriente-Felix A, Linneweber GA, Perea D, Wayland M, Shafer OT, Miguel-Aliaga Iet al., 2012, Remote control of renal physiology by the intestinal neuropeptide pigment-dispersing factor in Drosophila, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 109, Pages: 12177-12182, ISSN: 0027-8424

JOURNAL ARTICLE

Cognigni P, Bailey AP, Miguel-Aliaga I, 2011, Enteric Neurons and Systemic Signals Couple Nutritional and Reproductive Status with Intestinal Homeostasis, CELL METABOLISM, Vol: 13, Pages: 92-104, ISSN: 1550-4131

JOURNAL ARTICLE

Pulver SR, Cognigni P, Denholm B, Fabre C, Gu WXW, Linneweber G, Prieto-Godino L, Urbancic V, Zwart M, Miguel-Aliaga Iet al., 2011, Why flies? Inexpensive public engagement exercises to explain the value of basic biomedical research on Drosophila melanogaster, ADVANCES IN PHYSIOLOGY EDUCATION, Vol: 35, Pages: 384-392, ISSN: 1043-4046

JOURNAL ARTICLE

Suska A, Miguel-Aliaga I, Thor S, 2011, Segment-specific generation of Drosophila Capability neuropeptide neurons by multi-faceted Hox cues, DEVELOPMENTAL BIOLOGY, Vol: 353, Pages: 72-80, ISSN: 0012-1606

JOURNAL ARTICLE

Cognigni P, Thorne J, Bailey AP, Gould AP, Maddrell SHP, Miguel-Aliaga Iet al., 2010, The autonomic nervous system: does the body rule the mind, or does the mind rule the body?, Publisher: INFORMA HEALTHCARE, Pages: 10-10, ISSN: 0167-7063

CONFERENCE PAPER

Cognigni P, Linneweber G, Bailey A, Miguel-Aliaga Iet al., 2009, Development and function of visceral innervation in Drosophila, 16th Annual Conference of the International-Society-of-Development-Biologists, Publisher: ELSEVIER SCIENCE BV, Pages: S190-S190, ISSN: 0925-4773

CONFERENCE PAPER

Miguel-Aliaga I, Cognigni P, Groenke S, Bailey APet al., 2009, Development and physiology of enteric neurons in Drosophila, Publisher: WILEY-BLACKWELL PUBLISHING, INC, Pages: XIX-XIX, ISSN: 1350-1925

CONFERENCE PAPER

Miguel-Aliaga I, Thor S, 2009, Programmed cell death in the nervous system-a programmed cell fate?, CURRENT OPINION IN NEUROBIOLOGY, Vol: 19, Pages: 127-133, ISSN: 0959-4388

JOURNAL ARTICLE

Bardet P-L, Kolahgar G, Mynett A, Miguel-Aliaga I, Briscoe J, Meier P, Vincent J-Pet al., 2008, A fluorescent reporter of caspase activity for live imaging, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 105, Pages: 13901-13905, ISSN: 0027-8424

JOURNAL ARTICLE

Miguel-Aliaga I, Thor S, Gould AP, 2008, Postmitotic specification of Drosophila insulinergic neurons from pioneer neurons, PLOS BIOLOGY, Vol: 6, Pages: 538-551, ISSN: 1544-9173

JOURNAL ARTICLE

Baumgardt M, Miguel-Aliaga I, Karlsson D, Ekman H, Thor Set al., 2007, Specification of neuronal identities by feedforward combinatorial coding, PLOS BIOLOGY, Vol: 5, Pages: 295-308, ISSN: 1544-9173

JOURNAL ARTICLE

Sheldon TJ, Miguel-Aliaga I, Gould AP, Taylor WR, Conklin Det al., 2007, A novel family of single VWC-domain proteins in invertebrates, FEBS LETTERS, Vol: 581, Pages: 5268-5274, ISSN: 0014-5793

JOURNAL ARTICLE

Baumgardt M, Karlsson D, Miguel-Aliaga I, Thor Set al., 2006, Combinatorial codes specifying neuronal identities, Publisher: TAYLOR & FRANCIS LTD, Pages: 78-79, ISSN: 0167-7063

CONFERENCE PAPER

Miguel-Aliaga I, Thor S, Gould AP, 2006, Segmental control of death and differentiation in pioneer neurons of the ventral nerve cord, Publisher: TAYLOR & FRANCIS LTD, Pages: 180-180, ISSN: 0167-7063

CONFERENCE PAPER

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