Imperial College London

DrIstvanNagy

Faculty of MedicineDepartment of Surgery & Cancer

Reader in Nociceptive Mechanisms
 
 
 
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Contact

 

+44 (0)20 3315 8897i.nagy

 
 
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Assistant

 

Mr Faruq Noormohamed +44 (0)20 3315 8816

 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Summary

Following his graduation as an MD at University Medical School Debrecen, Hungary in 1982, Dr Nagy started to work as a neuroscientist. He obtained his PhD at the Hungarian Academy of Sciences in 1996. Recently he has also obtained the title of Dr. Habil.

Dr Nagy has been working on the mechanisms involved in peripheral and spinal neuronal processing for 30 years . He has been particularly interested in the neurochemistry, physiology and pharmacology of nociceptive processing.

Dr Nagy has been working at Imperial College London since 1998, where he is one of the leading basic pain scientists. His pioneering work on heat transduction mechanisms and interactions between the endovanilloid and endocannabinoid systems has significantly contributed to the knowledge, which underlies the recent development of novel pharmacological approaches for pain control.

Dr Nagy uses a broad repertoire of techniques including molecular, biochemical, electrophysiological, pharmacological, morphological and behavioural approaches. Dr Nagy is the principal author of many highly-cited, seminal publications in peer-reviewed journals and books. He is a regularly invited speaker, key-note presenter and session organiser at various international conferences.

As a principal investigator, Dr Nagy leads the work of a group of undergraduate and postgraduate students, as well as postdoctoral scientists. He has extensive collaboration with several academic and industrial scientists both within the UK and overseas.

Current actiities in Dr Nagy's laboratory:

Transduction mechanisms:

Dr Nagy has been working on transduction mechanisms in primary sensory neurons for more than 10 years. Currently Dr Nagy and his co-workers are interested in the mechanisms in mechanotransduction, particulalry in those which are involved the development of inflmmatory visceral hyper-reflexia.   

Endocannabinoid and endocannabinoid system:

In order to utalise the potential of the endovanilloid and endocannabinoid systems for pain control, Dr Nagy and his co-workers study the role of various enocannabinoid/endovanoilloid molecules on the rugulation of nociceptive processing in primary sensory neurosn and the spinal cord. In this work they pay particular attention on the role of anandamide, by studying the actions and metabolism of this molecule.  

Nociceptive mechanisms in burn injury:

In order to increase our understanding of the peripheral signalling mechanisms involved in the development of burn injury-associated pain, and to identify new target(s) for the development of novel analgesics for controlling burn injury-associated pain, Dr Nagy' laboratory is engaged in studies on signalling between agents accumulating in burnt tissues and sensory nerve endings innervating burnt tissues. In this work, Dr Nagy and his co-workers generate metabolomic and gene expression tissue databases of various degrees of burn injury (volunteer, burn-injured patients and rats) and rat primary sensory neurons, respectively. Analysing these databases will reveal putative targets for new therapeutic approaches to control pain in burn-injured patients.

Headache:

Dr Nagy has recently started to study mechanisms involved in the development of tension headache and migraine. He and his co-workers are particulalry interested in the role of hypothalamus, and mechanotransduction in trigeminal ganglionic neurons in the development of headache.

 

Publications

Journals

Nagy I, Torres-Perez JV, Adamek P, et al., THE NAv1.7 BLOCKER PROTOXIN II REDUCES BURN INJURY-INDUCED SPINAL NOCICEPTIVE PROCESSING, Journal of Molecular Medicine, ISSN:0946-2716

Nerandzic V, Mrozkova P, Adamek P, et al., 2017, Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N-arachidonoylphosphatidylethanolamine., Br J Pharmacol

Sousa-Valente J, Varga A, Torres-Perez JV, et al., 2017, Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons, Journal of Comparative Neurology, Vol:525, ISSN:0021-9967, Pages:1778-1796

Conference

Charrua, A, Paule, et al., Down-regulation of the TRPV1b splice variant in dorsal root ganglia innervating the inflamed urinary bladder of the rat., European Neuropeptide Club

Nagy, I., Interactions between the the two anandamide-responding receptors, the CB1 receptor and TRPV1 in nociceptive primary sensory neurons, 11th World Congress on Pain

More Publications