Imperial College London
Alternate

DrInesRibeiro Violante

Faculty of Medicine, Department of Brain Sciences

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 7994i.violante

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Violante:2023:10.1038/s41593-023-01456-8,
author = {Violante, IR and Alania, K and Cassarà, AM and Neufeld, E and Acerbo, E and Carron, R and Williamson, A and Kurtin, DL and Rhodes, E and Hampshire, A and Kuster, N and Boyden, ES and Pascual-Leone, A and Grossman, N},
doi = {10.1038/s41593-023-01456-8},
journal = {Nat Neurosci},
pages = {1994--2004},
title = {Non-invasive temporal interference electrical stimulation of the human hippocampus.},
url = {http://dx.doi.org/10.1038/s41593-023-01456-8},
volume = {26},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.
AU  - Violante,IR
AU  - Alania,K
AU  - Cassarà,AM
AU  - Neufeld,E
AU  - Acerbo,E
AU  - Carron,R
AU  - Williamson,A
AU  - Kurtin,DL
AU  - Rhodes,E
AU  - Hampshire,A
AU  - Kuster,N
AU  - Boyden,ES
AU  - Pascual-Leone,A
AU  - Grossman,N
DO  - 10.1038/s41593-023-01456-8
EP  - 2004
PY  - 2023///
SP  - 1994
TI  - Non-invasive temporal interference electrical stimulation of the human hippocampus.
T2  - Nat Neurosci
UR  - http://dx.doi.org/10.1038/s41593-023-01456-8
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37857775
VL  - 26
ER  -
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