Imperial College London
Alternate

ProfessorIanWilson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

i.wilson

 
 
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Location

 

311Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

564 results found

Ludlow M, Louden D, Handley A, Taylor S, Wright B, Wilson IDet al., 1999, Size exclusion chromatography with UV detection coupled to on-line <SUP>1</SUP>H-NMR and on-line collection <i>via</i> a dedicated interface for subsequent off-line FT-IR, ANALYTICAL COMMUNICATIONS, Vol: 36, Pages: 85-87, ISSN: 1359-7337

Journal article

Scarfe GB, Tugnait M, Wilson ID, Nicholson JKet al., 1999, Studies on the metabolism of 4-fluoroaniline and 4-fluoroacetanilide in rat: formation of 4-acetamidophenol (paracetamol) and its metabolites via defluorination and N-acetylation, XENOBIOTICA, Vol: 29, Pages: 205-216, ISSN: 0049-8254

Journal article

Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JKet al., 1999, Quantitative studies on the urinary metabolic fate of 2-chloro-4-trifluoromethylaniline in the rat using <SUP>19</SUP>F-NMR spectroscopy and directly coupled HPLC-NMR-MS, XENOBIOTICA, Vol: 29, Pages: 77-91, ISSN: 0049-8254

Journal article

Cupid BC, Holmes E, Wilson ID, Lindon JC, Nicholson JKet al., 1999, Quantitative structure-metabolism relationships (QSMR) using computational chemistry: pattern recognition analysis and statistical prediction of phase II conjugation reactions of substituted benzoic acids in the rat, XENOBIOTICA, Vol: 29, Pages: 27-42, ISSN: 0049-8254

Journal article

Schewitz J, Gfrörer P, Pusecker K, Tseng LH, Albert K, Bayer E, Wilson ID, Bailey NJ, Scarfe GB, Nicholson JK, Lindon JCet al., 1998, Directly coupled CZE-NMR and CEC-NMR spectroscopy for metabolite analysis:: paracetamol metabolites in human urine, ANALYST, Vol: 123, Pages: 2835-2837, ISSN: 0003-2654

Journal article

Olsen J, Martin P, Wilson ID, 1998, Molecular imprints as sorbents for solid phase extraction: potential and applications, ANALYTICAL COMMUNICATIONS, Vol: 35, Pages: 13H-14H, ISSN: 1359-7337

Journal article

Martin P, Wilson ID, 1998, Comparison of the properties of polymeric and C8 based materials for solid phase extraction, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 17, Pages: 1093-1100, ISSN: 0731-7085

Journal article

Smith RM, Chienthavorn O, Wilson ID, Wright Bet al., 1998, Superheated deuterium oxide reversed-phase chromatography coupled to proton nuclear magnetic resonance spectroscopy, ANALYTICAL COMMUNICATIONS, Vol: 35, Pages: 261-263, ISSN: 1359-7337

Journal article

Pusecker K, Schewitz J, Gfrorer P, Tseng LH, Albert K, Bayer E, Wilson ID, Bailey NJ, Scarfe GB, Nicholson JK, Lindon JCet al., 1998, On-flow identification of metabolites of paracetamol from human urine using directly coupled CZE-NMR and CEC-NMR spectroscopy, ANALYTICAL COMMUNICATIONS, Vol: 35, Pages: 213-215, ISSN: 1359-7337

Journal article

Phipps AN, Stewart J, Wright B, Wilson IDet al., 1998, Effect of diet on the urinary excretion of hippuric acid and other dietary-derived aromatics in rat. A complex interaction between diet, gut microflora and substrate specificity, XENOBIOTICA, Vol: 28, Pages: 527-537, ISSN: 0049-8254

Journal article

Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JKet al., 1998, <SUP>19</SUP>F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat:: a urinary excretion balance study without the use of radiolabelling, XENOBIOTICA, Vol: 28, Pages: 373-388, ISSN: 0049-8254

Journal article

Scarfe GB, Wright B, Clayton E, Taylor S, Wilson ID, Lindon JC, Nicholson JKet al., 1998, 19F-NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in rat: a urinary excretion balance study without the use of radiolabelling., Xenobiotica, Vol: 28, Pages: 373-388, ISSN: 0049-8254

1. The metabolic fate and urinary excretion of 2-bromo-4-trifluoromethylaniline has been studied in rat using 19F-NMR spectroscopic and directly coupled HPLC-NMR-MS methods. The compound was dosed to Sprague-Dawley rats (50 mg kg-1, i.p.) and urine collected over 0-8, 8-24 and 24-48 h post-dosing. 2. A total urinary recovery of 53.5 +/- 7.0% of the dose was achieved up to 48 h after dosing. The major metabolite in the urine was identified as 2-amino-3-bromo-5-trifluoromethylphenylsulphate accounting for a total of 35.7 +/- 6.2% of the dose. 3. Further metabolites detected were 2-bromo-4-trifluoromethylphenylhydroxylamine-1V-glucuronide (9.7 +/- 0.2% of the dose), 2-bromo-4-trifluoromethylaniline-N-glucuronide (3.0 +/- 0.3%) and 2-amino-3-bromo-5-trifluoromethylphenylglucuronide (2-St 0-4). Minor metabolites, including 2-bromo-4-trifluoromethylphenylhydroxylamine-O-glucuronide, 2-amino-3-bromo-5-trifluoromethylphenol and 2-bromo-4-trifluoromethylphenylsulphamate, in total accounted for 2.3 +/- 0.9% of the dose. 4. Directly coupled HPLC-NMR-MS and 19F-NMR spectroscopy proved to be efficient techniques for the unequivocal and rapid determination of the urinary metabolic fate and excretion balance of fluorinated xenobiotics without the need for radiolabelling.

Journal article

Wilson ID, Morgan ED, Lafont R, Wright Bet al., 1998, High-performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy -: Application to the ecdysteroids of <i>Silene otites</i>, JOURNAL OF CHROMATOGRAPHY A, Vol: 799, Pages: 333-336, ISSN: 0021-9673

Journal article

Smith RM, Chienthavorn O, Danks N, Wilson IDet al., 1998, Fluorescence detection in packed-column supercritical fluid chromatographic separations, Pages: 203-206, ISSN: 0021-9673

Propranolol and (9-acridinylamino)propranolol (9-AAP) have been separated by supercritical fluid chromatography with fluorescence detection by employing a simple pressure restrictor to protect the detector flow cell. The separations were carried out using a μBondapak C18 column with a mobile phase of 1% triethylamine in methanol-modified CO2 at 40°C. The excitation and emission wavelengths for propranolol were 317 run and 352 nm and for 9-AAP 245 nm and 413 nm, respectively. The sensitivity for propranolol detected by the fluorescence detector was 5.7 ng, approximately 8 times higher than by UV spectroscopic detection and was similar to the results for HPLC with fluorescence detection. A higher sensitivity (0,4 ng) was found for 9-AAP with fluorescence detection.

Conference paper

Clayton E, Taylor S, Wright B, Wilson IDet al., 1998, The application of high performance liquid chromatography, coupled to nuclear magnetic resonance spectroscopy and mass spectrometry (HPLC-NMR-MS), to the characterisation of ibuprofen metabolites from human urine, CHROMATOGRAPHIA, Vol: 47, Pages: 264-270, ISSN: 0009-5893

Journal article

Taylor SD, Wright B, Clayton E, Wilson IDet al., 1998, Practical aspects of the use of high performance liquid chromatography combined with simultaneous nuclear magnetic resonance and mass spectrometry, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, Vol: 12, Pages: 1732-1736, ISSN: 0951-4198

Journal article

Phipps AN, Wright B, Stewart J, Wilson IDet al., 1997, Use of proton NMR for determining changes in metabolite excretion profiles induced by dietary changes in the rat, Pharmaceutical Sciences, Vol: 3, Pages: 143-146, ISSN: 1356-6881

1H NMR spectroscopy was used to compare the endogenous urinary metabolite profiles of groups of Alp:AP(f)SD (Wistar-derived) and Zucker (obese negative) rats fed different diets. With one of the diets (Special Dietary Services), hippuric acid was found to be absent in urine from both strains of rat whilst another component, 3-(3 hydroxyphenyl) propionic acid (3-HPPA) was identified. Switching either strain of rat from this diet to an alternative (Harlan Teklad) resulted in the appearance of hippuric acid in the urine concomitantly with the disappearance of 3-HPPA. Oral administration of benzoic acid (200 mg kg-1) to animals fed the diet which did not produce urinary hippuric acid resulted in a massive increase in hippuric acid excretion in the urine indicating that the rats retained the capacity to synthesize this material. We conclude that the lack of hippuric acid precursors in the urine along with the presence of 3-HPPA is due to diet and not strain of animal.

Journal article

Nicholls AW, Lindon JC, Caddick S, Farrant RD, Wilson ID, Nicholson JKet al., 1997, NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat, XENOBIOTICA, Vol: 27, Pages: 1175-1186, ISSN: 0049-8254

Journal article

Swaisland GL, Wilson LA, Wilson ID, 1997, Reversed-phase high performance thin-layer chromatography of non-steroidal anti-inflammatory drugs, JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, Vol: 10, Pages: 372-374, ISSN: 0933-4173

Journal article

Poole CF, Wilson ID, 1997, Planar electrophoresis and electrochromatography: Time to revisit these techniques, JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, Vol: 10, Pages: 332-335, ISSN: 0933-4173

Journal article

Martin P, Morgan ED, Wilson ID, 1997, Effect of carbon loading on the extraction properties of C-18 bonded silica used for solid-phase extraction of acidic and basic analytes, ANALYTICAL CHEMISTRY, Vol: 69, Pages: 2972-2975, ISSN: 0003-2700

Journal article

Matthews DB, Hinton RH, Wright B, Wilson ID, Stevenson Det al., 1997, Bioanalysis of p-trifluoromethylmandelic acid and Mosher's acid by chiral gas chromatography and fluorine nuclear magnetic resonance to study chiral inversion: application to rat urine samples, JOURNAL OF CHROMATOGRAPHY B, Vol: 695, Pages: 279-285, ISSN: 0378-4347

Journal article

Wilson ID, Spraul M, Humpfer E, 1997, Thin-layer chromatography combined with high-resolution solid-state NMR for compound identification without substance elution: Preliminary results, JPC-JOURNAL OF PLANAR CHROMATOGRAPHY-MODERN TLC, Vol: 10, Pages: 217-219, ISSN: 0933-4173

Journal article

Nicholls AW, Farrant RD, Shockcor JP, Unger SE, Wilson ID, Lindon JC, Nicholson JKet al., 1997, NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Vol: 15, Pages: 901-910, ISSN: 0731-7085

Journal article

Wilson ID, Nicholson JK, Lindon JC, 1997, Characterisation of substances separated by chromatography: NMR & MS, GENETIC ENGINEERING NEWS, Vol: 17, Pages: 21-&, ISSN: 0270-6377

Journal article

Ashcroft AE, Major HJ, Wilson ID, Nicholls A, Nicholson JKet al., 1997, Application of capillary electrophoresis mass spectrometry to the analysis of urine samples from animals and man containing paracetamol and phenacetin and their metabolites, ANALYTICAL COMMUNICATIONS, Vol: 34, Pages: 41-43, ISSN: 1359-7337

Journal article

Martin P, Wilson ID, Morgan DE, Jones GR, Jones Ket al., 1997, Evaluation of a molecular-imprinted polymer for use in the solid phase extraction of propranolol from biological fluids, ANALYTICAL COMMUNICATIONS, Vol: 34, Pages: 45-47, ISSN: 1359-7337

Journal article

Scarfe GB, Wilson ID, Spraul M, Hofmann M, Braumann U, Lindon JC, Nicholson JKet al., 1997, Application of directly coupled high-performance liquid chromatography nuclear magnetic resonance mass spectrometry to the detection and characterisation of the metabolites of 2-bromo-4-trifluoromethylaniline in rat urine, ANALYTICAL COMMUNICATIONS, Vol: 34, Pages: 37-39, ISSN: 1359-7337

Journal article

Lindon JC, Nicholson JK, Sidelmann UG, Wilson IDet al., 1997, Directly-coupled HPLC-NMR and its application to drug metabolism, Drug Metabolism Reviews, Vol: 29, Pages: 705-746

Journal article

Shockcor JP, Unger SE, Wilson ID, Foxall PJD, Nicholson JK, Lindon JCet al., 1996, Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine, ANALYTICAL CHEMISTRY, Vol: 68, Pages: 4431-4435, ISSN: 0003-2700

Journal article

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