Imperial College London
Alternate

ProfessorIanWilson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

i.wilson

 
 
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Location

 

311Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Scheer:2015:10.1016/j.drudis.2015.09.002,
author = {Scheer, N and Wilson, ID},
doi = {10.1016/j.drudis.2015.09.002},
journal = {Drug Discovery Today},
pages = {250--263},
title = {A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity},
url = {http://dx.doi.org/10.1016/j.drudis.2015.09.002},
volume = {21},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Mice that have been genetically humanized for proteins involved in drug metabolism and toxicity and mice engrafted with human hepatocytes are emerging and promising in vivo models for an improved prediction of the pharmacokinetic, drug–drug interaction and safety characteristics of compounds in humans. The specific advantages and disadvantages of these models should be carefully considered when using them for studies in drug discovery and development. Here, an overview on the corresponding genetically humanized and chimeric liver humanized mouse models described to date is provided and illustrated with examples of their utility in drug metabolism and toxicity studies. We compare the strength and weaknesses of the two different approaches, give guidance for the selection of the appropriate model for various applications and discuss future trends and perspectives.
AU  - Scheer,N
AU  - Wilson,ID
DO  - 10.1016/j.drudis.2015.09.002
EP  - 263
PY  - 2015///
SN  - 1359-6446
SP  - 250
TI  - A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity
T2  - Drug Discovery Today
UR  - http://dx.doi.org/10.1016/j.drudis.2015.09.002
UR  - http://hdl.handle.net/10044/1/38389
VL  - 21
ER  -
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