Imperial College London
Alternate

ProfessorIanWilson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

i.wilson

 
 
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Location

 

311Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Goveia:2016:10.15252/emmm.201606798,
author = {Goveia, J and Pircher, A and Conradi, L-C and Kalucka, J and Lagani, V and Dewerchin, M and Eelen, G and DeBerardinis, RJ and Wilson, ID and Carmeliet, P},
doi = {10.15252/emmm.201606798},
journal = {EMBO Molecular Medicine},
pages = {1134--1142},
title = {Metaanalysis of clinical metabolic profiling studies in cancer: challenges and opportunities},
url = {http://dx.doi.org/10.15252/emmm.201606798},
volume = {8},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Cancer cell metabolism has received increasing attention. Despite a boost in the application of clinical metabolic profiling (CMP) in cancer patients, a metaanalysis has not been performed. The primary goal of this study was to assess whether public accessibility of metabolomics data and identification and reporting of metabolites were sufficient to assess which metabolites were consistently altered in cancer patients. We therefore retrospectively curated data from CMP studies in cancer patients published during 5 recent years and used an established votecounting method to perform a semiquantitative metaanalysis of metabolites in tumor tissue and blood. This analysis confirmed wellknown increases in glycolytic metabolites, but also unveiled unprecedented changes in other metabolites such as ketone bodies and amino acids (histidine, tryptophan). However, this study also highlighted that insufficient public accessibility of metabolomics data, and inadequate metabolite identification and reporting hamper the discovery potential of metaanalyses of CMP studies, calling for improved standardization of metabolomics studies.
AU  - Goveia,J
AU  - Pircher,A
AU  - Conradi,L-C
AU  - Kalucka,J
AU  - Lagani,V
AU  - Dewerchin,M
AU  - Eelen,G
AU  - DeBerardinis,RJ
AU  - Wilson,ID
AU  - Carmeliet,P
DO  - 10.15252/emmm.201606798
EP  - 1142
PY  - 2016///
SN  - 1757-4676
SP  - 1134
TI  - Metaanalysis of clinical metabolic profiling studies in cancer: challenges and opportunities
T2  - EMBO Molecular Medicine
UR  - http://dx.doi.org/10.15252/emmm.201606798
UR  - http://hdl.handle.net/10044/1/41034
VL  - 8
ER  -
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