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@article{Coen:2015:10.1002/9780470034590.emrstm1408,
author = {Coen, M and Wilson, ID},
doi = {10.1002/9780470034590.emrstm1408},
journal = {eMagRes},
pages = {277--287},
title = {Preclinical drug efficacy and safety using NMR spectroscopy},
url = {http://dx.doi.org/10.1002/9780470034590.emrstm1408},
volume = {4},
year = {2015}
}

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TY  - JOUR
AB  - One of the earliest applications of the use of NMR spectroscopy for the analysis of biofluids and tissues was the study of the effects of drugs on preclinical species (mainly rodents). This approach provided novel mechanistic insight into toxic and pathological processes at a systems level. Such metabonomic or metabolic profiling studies follow the small molecule alterations that occur across time in biofluids and tissues in response to changes in physiological status, therapeutic intervention, development of disease, or toxicity. In the context of preclinical safety assessment, this approach enables unique metabolic phenotypes to be identified, that reflect onset, progression, and recovery from toxic insult. Here, the analytical techniques used to obtain these metabolic profiles are introduced together with the multivariate statistical tools used to interrogate metabolic profiles.
AU  - Coen,M
AU  - Wilson,ID
DO  - 10.1002/9780470034590.emrstm1408
EP  - 287
PY  - 2015///
SN  - 2055-6101
SP  - 277
TI  - Preclinical drug efficacy and safety using NMR spectroscopy
T2  - eMagRes
UR  - http://dx.doi.org/10.1002/9780470034590.emrstm1408
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000218802100011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470034590.emrstm1408
VL  - 4
ER  -

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