Imperial College London
Alternate

ProfessorIanWilson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

i.wilson

 
 
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Location

 

311Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Athersuch:2018:10.1039/C7TX00340D,
author = {Athersuch, TJ and Antoine, DJ and Boobis, AR and Coen, M and Daly, AK and Possamai, L and Nicholson, JK and Wilson, ID},
doi = {10.1039/C7TX00340D},
journal = {Toxicology Research},
pages = {347--357},
title = {Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective},
url = {http://dx.doi.org/10.1039/C7TX00340D},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity. The pharmacological properties of APAP are the focus of some activity, with the role of the metabolite N-arachidonoylaminophenol (AM404) still a topic of debate. However, that the hepatotoxicity of APAP results from the production of the reactive metabolite N-acetyl-p-benzoquinoneimine (NAPQI/NABQI) that can deplete glutathione, react with cellular macromolecules, and initiate cell death, is now beyond dispute. The disruption of cellular pathways that results from the production of NAPQI provides a source of potential biomarkers of the severity of the damage. Research in this area has provided new diagnostic markers such as the microRNA miR-122 as well as mechanistic biomarkers associated with apoptosis, mitochondrial dysfunction, inflammation and tissue regeneration. Additionally, biomarkers of, and systems biology models for, glutathione depletion have been developed. Furthermore, there have been significant advances in determining the role of both the innate immune system and genetic factors that might predispose individuals to APAP-mediated toxicity. This perspective highlights some of the progress in current APAP-related research.
AU  - Athersuch,TJ
AU  - Antoine,DJ
AU  - Boobis,AR
AU  - Coen,M
AU  - Daly,AK
AU  - Possamai,L
AU  - Nicholson,JK
AU  - Wilson,ID
DO  - 10.1039/C7TX00340D
EP  - 357
PY  - 2018///
SN  - 2045-452X
SP  - 347
TI  - Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective
T2  - Toxicology Research
UR  - http://dx.doi.org/10.1039/C7TX00340D
UR  - http://hdl.handle.net/10044/1/57612
VL  - 7
ER  -
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