Imperial College London
Alternate

ProfessorIanWilson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

i.wilson

 
 
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Location

 

311Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Weidolf:2016:10.1002/9781118949689.ch6,
author = {Weidolf, L and Wilson, ID},
booktitle = {Metabolite Safety in Drug Development},
doi = {10.1002/9781118949689.ch6},
pages = {141--176},
title = {Understanding drug metabolism in humans: In vivo},
url = {http://dx.doi.org/10.1002/9781118949689.ch6},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - This chapter describes the strategies and tactics that can be used in in vivo studies to help provide the required knowledge and understanding of in vivo metabolism, especially in humans, to provide the best outcomes for candidate drugs as they progress through development and toward clinical use. A final preparation for the human radiolabeled study is to perform a quantitative tissue distribution study which is most often satisfied by performing a quantitative whole-body autoradiography (QWBA) study. Where metabolism is thought to be primarily undertaken in the liver, the chimeric humanized mouse model may represent a very useful means of investigating human-specific drug metabolism. Transgenic mice have been developed that are humanized in the liver (or gut) for the aryl hydrocarbon receptor (AhR), constitutive androstane receptor (CAR), peroxisome proliferator-activated receptor alpha (PPARa), and pregnane X receptor (PXR), all of which have importance in drug metabolism.
AU  - Weidolf,L
AU  - Wilson,ID
DO  - 10.1002/9781118949689.ch6
EP  - 176
PY  - 2016///
SN  - 9781118949658
SP  - 141
TI  - Understanding drug metabolism in humans: In vivo
T1  - Metabolite Safety in Drug Development
UR  - http://dx.doi.org/10.1002/9781118949689.ch6
ER  -
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