Imperial College London

DrIainJohnston

Faculty of Natural SciencesDepartment of Mathematics

Academic Visitor
 
 
 
//

Contact

 

iain.johnston Website

 
 
//

Location

 

548Huxley BuildingSouth Kensington Campus

//

Summary

 

Publications

Publication Type
Year
to

37 results found

Aryaman J, Hoitzing H, Burgstaller JP, Johnston IG, Jones NSet al., 2017, Mitochondrial heterogeneity, metabolic scaling and cell death, BIOESSAYS, Vol: 39, ISSN: 0265-9247

JOURNAL ARTICLE

Colijn C, Jones N, Johnston IG, Yaliraki S, Barahona Met al., 2017, Toward Precision Healthcare: Context and Mathematical Challenges, FRONTIERS IN PHYSIOLOGY, Vol: 8, ISSN: 1664-042X

JOURNAL ARTICLE

Mitchell J, Johnston IG, Bassel GW, 2017, Variability in seeds: biological, ecological, and agricultural implications, JOURNAL OF EXPERIMENTAL BOTANY, Vol: 68, Pages: 809-817, ISSN: 0022-0957

JOURNAL ARTICLE

Topham AT, Taylor RE, Yan D, Nambara E, Johnston IG, Bassel GWet al., 2017, Temperature variability is integrated by a spatially embedded decision-making center to break dormancy in Arabidopsis seeds, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 114, Pages: 6629-6634, ISSN: 0027-8424

JOURNAL ARTICLE

Diot A, Dombi E, Lodge T, Liao C, Morten K, Carver J, Wells D, Child T, Johnston IG, Williams S, Poulton Jet al., 2016, Modulating mitochondrial quality in disease transmission: towards enabling mitochondrial DNA disease carriers to have healthy children, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 44, Pages: 1091-1100, ISSN: 0300-5127

JOURNAL ARTICLE

Johnston IG, 2016, Multiple hypothesis correction is vital and undermines reported mtDNA links to diseases including AIDS, cancer, and Huntingdon's, MITOCHONDRIAL DNA PART A, Vol: 27, Pages: 3423-3427, ISSN: 2470-1394

JOURNAL ARTICLE

Johnston IG, Jones NS, 2016, Evolution of Cell-to-Cell Variability in Stochastic, Controlled, Heteroplasmic mtDNA Populations, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 99, Pages: 1150-1162, ISSN: 0002-9297

JOURNAL ARTICLE

Johnston IG, Williams BP, 2016, Evolutionary Inference across Eukaryotes Identifies Specific Pressures Favoring Mitochondrial Gene Retention, CELL SYSTEMS, Vol: 2, Pages: 101-111, ISSN: 2405-4712

JOURNAL ARTICLE

Larson HJ, de Figueiredo A, Zhao X, Schulz WS, Verger P, Johnston IG, Cook AR, Jones NSet al., 2016, The State of Vaccine Confidence 2016: Global Insights Through a 67-Country Survey, EBIOMEDICINE, Vol: 12, Pages: 295-301, ISSN: 2352-3964

JOURNAL ARTICLE

Potter M, Badder L, Hoade Y, Johnston IG, Morten KJet al., 2016, Monitoring Intracellular Oxygen Concentration: Implications for Hypoxia Studies and Real-Time Oxygen Monitoring, 42nd Annual Meeting of International-Society-on-Oxygen-Transport-to-Tissue, Publisher: SPRINGER, Pages: 257-263, ISSN: 0065-2598

CONFERENCE PAPER

Røyrvik EC, Burgstaller JP, Johnston IG, 2016, mtDNA diversity in human populations highlights the merit of haplotype matching in gene therapies., Mol Hum Reprod, Vol: 22, Pages: 809-817

STUDY QUESTION: Does mitochondrial DNA (mtDNA) diversity in modern human populations potentially pose a challenge, via mtDNA segregation, to mitochondrial replacement therapies? SUMMARY ANSWER: The magnitude of mtDNA diversity in modern human populations is as high as in mammalian model systems where strong mtDNA segregation is observed; consideration of haplotype pairs and/or haplotype matching can help avoid these potentially deleterious effects. WHAT IS KNOWN ALREADY: In mammalian models, substantial proliferative differences are observed between different mtDNA haplotypes in cellular admixtures, with larger proliferative differences arising from more diverse haplotype pairings. If maternal mtDNA is 'carried over' in human gene therapies, these proliferative differences could lead to its amplification in the resulting offspring, potentially leading to manifestation of the disease that the therapy was designed to avoid-but existing studies have not investigated whether mtDNA diversity in modern human populations is sufficient to permit significant amplification. STUDY DESIGN, SIZE, DURATION: This theoretical study used over 7500 human mtDNA sequences from The National Center for Biotechnology Information (NCBI), a range of international and British mtDNA surveys, and 2011 census data. PARTICIPANTS/MATERIALS, SETTING, METHODS: A stochastic simulation approach was used to model random haplotype pairings from within different regions. In total, 1000 simulated pairings were analysed using the basic local alignment search tool (BLAST) for each region. Previous data from mouse models were used to estimate proliferative differences. MAIN RESULTS AND THE ROLE OF CHANCE: Even within the same haplogroup, differences of around 20-80 single-nucleotide polymorphisms (SNPs) are common between mtDNAs admixed in random pairings. These values are sufficient to lead to substantial segregation in mouse models over an organismal lifetime, even given low starting heteroplasmy, inducin

JOURNAL ARTICLE

de Figueiredo A, Johnston IG, Smith DMD, Agarwal S, Larson HJ, Jones NSet al., 2016, Forecasting time-series trends in vaccination coverage and their links with socio-economic factors: A global analysis over 30 years, Lancet Global Health, ISSN: 2214-109X

Background Incomplete immunisation coverage causes preventable illness and death in both the developing anddeveloped world. Identifying factors that may modulate coverage can inform effective immunisation programmes andpolicies.Methods We perform a data-driven analysis of unprecedented scale, examining time-varying trends in Diphtheriatetanus-pertussiscoverage across 190 countries over the past three decades. Gaussian process regression is employedto forecast future coverage rates and provide a Vaccine Performance Index: a summary measure of the strength ofimmunisation coverage in a country.Findings Overall vaccine coverage has increased in all five world regions between 1980 and 2010, with markedvariation in volatility and trends. Our Vaccine Performance Index identifies 53 countries with a less than 50% chanceof missing the Global Vaccine Action Plan (GVAP) target of 90% worldwide DTP3 coverage by 2015, in agreementwith recent immunisation data. These countries are mostly sub-Saharan and South Asian, but Austria and Ukraine inEurope also feature. Factors associated with DTP3 immunisation coverage vary by world-region: personal income(! = 0.66, ' < 0.001) and government health spending (! = 0.66, ' < 0.01) are particularly informative in theEastern Mediterranean between 1980 and 2010, whilst primary school completion is informative in Africa (! =0.56, ' < 0.001) over the same time. The fraction of births attended by skilled health staff is significantly informativeacross many world regionsInterpretation A Vaccine Performance Index can highlight countries at risk identifying the strength and resilience ofimmunisation programmes. Weakening correlations with socio-economic factors indicate a need to tackle vaccineconfidence whereas strengthening correlations points to clear factors to address.

JOURNAL ARTICLE

de Figueiredo A, Johnston IG, Smith DMD, Agarwal S, Larson HJ, Jones NSet al., 2016, Forecasted trends in vaccination coverage and correlations with socioeconomic factors: a global time-series analysis over 30 years, LANCET GLOBAL HEALTH, Vol: 4, Pages: E726-E735, ISSN: 2214-109X

JOURNAL ARTICLE

Burgstaller JP, Johnston IG, Poulton J, 2015, Mitochondrial DNA disease and developmental implications for reproductive strategies, MOLECULAR HUMAN REPRODUCTION, Vol: 21, Pages: 11-22, ISSN: 1360-9947

JOURNAL ARTICLE

Diot A, Hinks-Roberts A, Lodge T, Liao C, Dombi E, Morten K, Brady S, Fratter C, Carver J, Muir R, Davis R, Greene CJ, Johnston I, Hilton-Jones D, Sue C, Mortiboys H, Poulton Jet al., 2015, A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA, PHARMACOLOGICAL RESEARCH, Vol: 100, Pages: 24-35, ISSN: 1043-6618

JOURNAL ARTICLE

Hoitzing H, Johnston IG, Jones NS, 2015, What is the function of mitochondrial networks? A theoretical assessment of hypotheses and proposal for future research, BIOESSAYS, Vol: 37, Pages: 687-700, ISSN: 0265-9247

JOURNAL ARTICLE

Johnston IG, Burgstaller JP, Havlicek V, Kolbe T, Ruelicke T, Brem G, Poulton J, Jones NSet al., 2015, Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism, ELIFE, Vol: 4, ISSN: 2050-084X

JOURNAL ARTICLE

Johnston IG, Jones NS, 2015, Closed-form stochastic solutions for non-equilibrium dynamics and inheritance of cellular components over many cell divisions, PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Vol: 471, ISSN: 1364-5021

JOURNAL ARTICLE

de Figueiredo A, Johnston I, Smith DMD, Larson HJ, Jones Net al., 2015, Changing socioeconomic determinants of childhood vaccines: a global analysis over three decades, LANCET GLOBAL HEALTH, Vol: 3, Pages: 20-20, ISSN: 2214-109X

JOURNAL ARTICLE

Burgstaller JP, Johnston IG, Jones NS, Albrechtova J, Kolbe T, Vogl C, Futschik A, Mayrhofer C, Klein D, Sabitzer S, Blattner M, Guelly C, Poulton J, Ruelicke T, Pialek J, Steinborn R, Brem Get al., 2014, mtDNA Segregation in Heteroplasmic Tissues Is Common In Vivo and Modulated by Haplotype Differences and Developmental Stage, CELL REPORTS, Vol: 7, Pages: 2031-2041, ISSN: 2211-1247

JOURNAL ARTICLE

El Zawily AM, Schwarzlaender M, Finkemeier I, Johnston IG, Benamar A, Cao Y, Gissot C, Meyer AJ, Wilson K, Datla R, Macherel D, Jones NS, Logan DCet al., 2014, FRIENDLY Regulates Mitochondrial Distribution, Fusion, and Quality Control in Arabidopsis, PLANT PHYSIOLOGY, Vol: 166, Pages: 808-U517, ISSN: 0032-0889

JOURNAL ARTICLE

Greenbury SF, Johnston IG, Louis AA, Ahnert SEet al., 2014, A tractable genotype-phenotype map modelling the self-assembly of protein quaternary structure, JOURNAL OF THE ROYAL SOCIETY INTERFACE, Vol: 11, ISSN: 1742-5689

JOURNAL ARTICLE

Johnston IG, 2014, Efficient parametric inference for stochastic biological systems with measured variability, STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY, Vol: 13, Pages: 379-390, ISSN: 2194-6302

JOURNAL ARTICLE

Johnston IG, Rickett BC, Jones NS, 2014, Explicit Tracking of Uncertainty Increases the Power of Quantitative Rule-of-Thumb Reasoning in Cell Biology, BIOPHYSICAL JOURNAL, Vol: 107, Pages: 2612-2617, ISSN: 0006-3495

JOURNAL ARTICLE

Schwarzlaender M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, Johnstonn IG, Jones NS, Logan DC, Morgan B, Mueller FL, Nicholls DG, Remington SJ, Schumacker PT, Winterbourn CC, Sweetlove LJ, Meyer AJ, Dick TP, Murphy MPet al., 2014, The 'mitoflash' probe cpYFP does not respond to superoxide, NATURE, Vol: 514, Pages: E12-E14, ISSN: 0028-0836

JOURNAL ARTICLE

Williams BP, Johnston IG, Covshoff S, Hibberd JMet al., 2013, Phenotypic landscape inference reveals multiple evolutionary paths to C-4 photosynthesis, ELIFE, Vol: 2, ISSN: 2050-084X

JOURNAL ARTICLE

Williams BP, Johnston IG, Covshoff S, Hibberd JMet al., 2013, Phenotypic landscape inference reveals multiple evolutionary paths to C<inf>4</inf>photosynthesis, eLife, Vol: 2

© Williams et al. C 4 photosynthesis has independently evolved from the ancestral C 3 pathway in at least 60 plant lineages, but, as with other complex traits, how it evolved is unclear. Here we show that the polyphyletic appearance of C 4 photosynthesis is associated with diverse and flexible evolutionary paths that group into four major trajectories. We conducted a meta-analysis of 18 lineages containing species that use C 3 , C 4 , or intermediate C 3 – C 4 forms of photosynthesis to parameterise a 16-dimensional phenotypic landscape. We then developed and experimentally verified a novel Bayesian approach based on a hidden Markov model that predicts how the C 4 phenotype evolved. The alternative evolutionary histories underlying the appearance of C 4 photosynthesis were determined by ancestral lineage and initial phenotypic alterations unrelated to photosynthesis. We conclude that the order of C 4 trait acquisition is flexible and driven by non-photosynthetic drivers. This flexibility will have facilitated the convergent evolution of this complex trait.

JOURNAL ARTICLE

Johnston I, 2012, The chaos within: Exploring noise in cellular biology, Significance, Vol: 9, Pages: 17-21, ISSN: 1740-9705

JOURNAL ARTICLE

Johnston IG, Gaal B, das Neves RP, Enver T, Iborra FJ, Jones NSet al., 2012, Mitochondrial Variability as a Source of Extrinsic Cellular Noise, PLOS COMPUTATIONAL BIOLOGY, Vol: 8, ISSN: 1553-734X

JOURNAL ARTICLE

Schaper S, Johnston IG, Louis AA, 2012, Epistasis can lead to fragmented neutral spaces and contingency in evolution, PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 279, Pages: 1777-1783, ISSN: 0962-8452

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00777805&limit=30&person=true