Publications
932 results found
KANANEN K, MARKKULA M, RAINIO E, et al., 1995, GONADAL TUMORIGENESIS IN TRANSGENIC MICE BEARING THE MOUSE INHIBIN ALPHA-SUBUNIT PROMOTER SIMIAN-VIRUS T-ANTIGEN FUSION GENE - CHARACTERIZATION OF OVARIAN-TUMORS AND ESTABLISHMENT OF GONADOTROPIN-RESPONSIVE GRANULOSA-CELL LINES, MOLECULAR ENDOCRINOLOGY, Vol: 9, Pages: 616-627, ISSN: 0888-8809
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- Citations: 122
HAAVISTO AM, PETTERSSON K, BERGENDAHL M, et al., 1995, OCCURRENCE AND BIOLOGICAL PROPERTIES OF A COMMON GENETIC VARIANT OF LUTEINIZING-HORMONE, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 80, Pages: 1257-1263, ISSN: 0021-972X
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- Citations: 127
PERHEENTUPA A, BERGENDAHL M, HUHTANIEMI I, 1995, MODULATION OF GONADOTROPIN-SECRETION AT THE PITUITARY LEVEL BY TESTOSTERONE IN GONADOTROPIN-RELEASING HORMONE-TREATED MALE-RATS DURING FOOD-DEPRIVATION, BIOLOGY OF REPRODUCTION, Vol: 52, Pages: 808-813, ISSN: 0006-3363
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- Citations: 11
MARKKULA M, KANANEN K, PAUKKU T, et al., 1995, INDUCED ABLATION OF GONADOTROPINS IN TRANSGENIC MICE EXPRESSING HERPES-SIMPLEX VIRUS THYMIDINE KINASE UNDER THE FSH BETA-SUBUNIT PROMOTER, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 108, Pages: 1-9, ISSN: 0303-7207
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- Citations: 10
RANNIKKI AS, ZHANG FP, HUHTANIEMI IT, 1995, ONTOGENY OF FOLLICLE-STIMULATING-HORMONE RECEPTOR GENE-EXPRESSION IN THE RAT TESTIS AND OVARY, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 107, Pages: 199-208, ISSN: 0303-7207
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- Citations: 121
HUHTANIEMI I, TOPPARI J, 1995, Endocrine, paracrine and autocrine regulation of testicular steroidogenesis, TISSUE RENIN-ANGIOTENSIN SYSTEMS, Vol: 377, Pages: 33-54, ISSN: 0065-2598
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- Citations: 51
Huhtaniemi I, 1995, Molecular aspects of the ontogeny of the pituitary-gonadal axis, REPRODUCTION FERTILITY AND DEVELOPMENT, Vol: 7, Pages: 1025-1035, ISSN: 1031-3613
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- Citations: 39
Skoblina MN, Nikiforova GP, Kondrat'eva OT, et al., 1995, [The role of chloride channels and chlorine ions in regulating the in-vitro chorionic gonadotropin-stimulated maturation of oocytes in the clawed toad]., Ontogenez, Vol: 26, Pages: 356-360, ISSN: 0475-1450
The blocker of chloride channels SITS (4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid) (1 and 10 microM) reliable inhibited maturation of Xenopus laevis oocytes stimulated in vitro by human chorionic gonadotropin (5-40 MU/ml) and decreased the progesterone content of the incubation medium. The effect of SITS was dose-dependent and decreased with the increase of the hormone concentration. When the chloride ions in the medium were substituted for equimolar concentrations of sodium, potassium and calcium glutamates or of sodium or potassium chlorides for, respectively, glutamine and aspartate, the percentage of definitive oocytes (1.2-1.4 mm), maturing under the influence of human chorionic gonadotropin and the progesterone contents of the incubation medium increased, the certain part of smaller oocytes (0.9-1 mm).
Skoblina MN, Huhtaniemi I, 1995, [The role of chlorine ions in progesterone production and oocyte maturation induced by a pituitary suspension in the follicles of the common frog]., Ontogenez, Vol: 26, Pages: 139-145, ISSN: 0475-1450
Chloride channel blockers SITS (4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonic acid) and DIDS (4,4'-diisothiocyanostilbene-2,2'-disulphonic acid) significantly suppressed progesterone production (0.01-10 microM) in Rana temporaria follicle-enclosed oocytes and oocyte maturation (0.1-10 microM) stimulated by the homologous pituitary suspension (0.00125-0.005 pit/ml). Inhibition was dose-dependent. SITS (1 and 10 microM) did not affect the production of progesterone stimulated by dibutyrylcyclic AMP (2 and 3 mM). The substitution of chloride salts for equimolar concentrations of corresponding gluconates or of sodium chloride for sodium methanesulfonate also significantly increased the production of progesterone stimulated by the pituitary suspension (0.00125-0.0025 pit/ml) and its production in the intact follicle-enclosed oocytes in four out of six females. The reduction of extracellular chloride concentration significantly potentiated the "spontaneous" maturation of oocytes of all females.
Skoblina MN, Huhtaniemi I, Matikainen T, 1995, [The nuclei of the follicular cells regulate steroidogenesis stimulated by a pituitary suspension in the follicles of the common frog in vitro]., Ontogenez, Vol: 26, Pages: 446-452, ISSN: 0475-1450
It has already been shown that the follicle cell nuclei are not involved in regulation of amphibian oocyte maturation stimulated by the gonadotropic hormones (Skoblina and Kondrat'eva, 1992). In order to elucidate their involvement in regulation of steroidogenesis, we determined changes in the content of progesterone, testosterone, and estradiol-17beta in the common frog follicles stimulated by the pituitary suspension after preliminary treatment with actinomycin D and without it. Treatment with actinomycin D (5 micrograms/ml) reliably decreased the content of progesterone and increased that of testosterone. The content of estradiol-17beta in the control and actinomycin-treated follicles was below the method sensitivity. Treatment of the follicles with the inhibitor of chloride channels SITS (10 microM) reduced the progesterone content to the initial level, did not affect the testosterone content and suppressed oocyte maturation.
CHEN HL, HARDY MP, HUHTANIEMI I, et al., 1994, AGE-RELATED DECREASED LEYDIG-CELL TESTOSTERONE PRODUCTION IN THE BROWN-NORWAY RAT, JOURNAL OF ANDROLOGY, Vol: 15, Pages: 551-557, ISSN: 0196-3635
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- Citations: 133
LAPCIK O, PERHEENTUPA A, BICIKOVA M, et al., 1994, THE EFFECT OF EPITESTOSTERONE ON GONADOTROPIN SYNTHESIS AND SECRETION, JOURNAL OF ENDOCRINOLOGY, Vol: 143, Pages: 353-358, ISSN: 0022-0795
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- Citations: 10
BERGENDAHL M, HUHTANIEMI I, 1994, THE TIME SINCE CASTRATION INFLUENCES THE EFFECTS OF SHORT-TERM STARVATION ON GONADOTROPIN-SECRETION IN MALE-RATS, JOURNAL OF ENDOCRINOLOGY, Vol: 143, Pages: 209-219, ISSN: 0022-0795
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- Citations: 16
TENASEMPERE M, ZHANG FP, HUHTANIEMI I, 1994, PERSISTENT EXPRESSION OF A TRUNCATED FORM OF THE LUTEINIZING-HORMONE RECEPTOR MESSENGER-RIBONUCLEIC-ACID IN THE RAT TESTIS AFTER SELECTIVE LEYDIG-CELL DESTRUCTION BY ETHYLENE DIMETHANE SULFONATE, ENDOCRINOLOGY, Vol: 135, Pages: 1018-1024, ISSN: 0013-7227
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- Citations: 51
DONG QH, BERGENDAHL M, HUHTANIEMI I, et al., 1994, EFFECT OF UNDERNUTRITION ON PULSATILE LUTEINIZING-HORMONE (LH) SECRETION IN CASTRATE AND INTACT MALE-RATS USING AN ULTRASENSITIVE IMMUNOFLUOROMETRIC LH ASSAY, ENDOCRINOLOGY, Vol: 135, Pages: 745-750, ISSN: 0013-7227
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- Citations: 32
PELTOLA V, MANTYLA E, HUHTANIEMI I, et al., 1994, LIPID-PEROXIDATION AND ANTIOXIDANT ENZYME-ACTIVITIES IN THE RAT TESTIS AFTER CIGARETTE-SMOKE INHALATION OR ADMINISTRATION OF POLYCHLORINATED-BIPHENYLS OR POLYCHLORINATED NAPHTHALENES, JOURNAL OF ANDROLOGY, Vol: 15, Pages: 353-361, ISSN: 0196-3635
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- Citations: 79
PAKARINEN P, PROSHLYAKOVA E, HUHTANIEMI I, 1994, PITUITARY-GONADAL INTERACTIONS IN PERINATAL RATS - RELATIONSHIPS OF PLASMA LUTEINIZING-HORMONE AND TESTOSTERONE CONCENTRATIONS, AND PITUITARY LEVELS OF LH SUBUNIT MESSENGER-RNAS, NEUROENDOCRINOLOGY, Vol: 60, Pages: 42-49, ISSN: 0028-3835
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- Citations: 13
ESKOLA V, RANNIKKO A, HUHTANIEMI I, et al., 1994, ONTOGENY OF THE INHIBITORY GUANINE-NUCLEOTIDE-BINDING REGULATORY PROTEIN IN THE RAT TESTIS - MESSENGER-RNA EXPRESSION AND MODULATION OF LH AND FSH ACTION, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 102, Pages: 63-68, ISSN: 0303-7207
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- Citations: 14
MATIKAINEN T, HAAVISTO AM, PERMI J, et al., 1994, EFFECTS OF ESTROGEN-TREATMENT ON SERUM GONADOTROPIN BIOACTIVITY, IMMUNOREACTIVITY AND ISOHORMONE DISTRIBUTION, AND ON IMMUNOREACTIVE INHIBIN LEVELS, IN PROSTATIC-CANCER PATIENTS, CLINICAL ENDOCRINOLOGY, Vol: 40, Pages: 743-750, ISSN: 0300-0664
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- Citations: 13
MATIKAINEN T, TOPPARI J, VIHKO KK, et al., 1994, EFFECTS OF RECOMBINANT HUMAN FSH IN IMMATURE HYPOPHYSECTOMIZED MALE-RATS - EVIDENCE FOR LEYDIG CELL-MEDIATED ACTION ON SPERMATOGENESIS, JOURNAL OF ENDOCRINOLOGY, Vol: 141, Pages: 449-457, ISSN: 0022-0795
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- Citations: 21
PAKARINEN P, NIEMIMAA T, HUHTANIEMI IT, et al., 1994, TRANSCRIPTIONAL AND TRANSLATIONAL REGULATION OF LH, PROLACTIN AND THEIR TESTICULAR RECEPTORS BY HCG AND BROMOCRIPTINE TREATMENTS IN ADULT AND NEONATAL RATS, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 101, Pages: 37-47, ISSN: 0303-7207
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- Citations: 17
KAIPIA A, TOPPARI J, HUHTANIEMI I, et al., 1994, SEX DIFFERENCE IN THE ACTION OF ACTIVIN-A ON CELL-PROLIFERATION OF DIFFERENTIATING RAT GONAD, ENDOCRINOLOGY, Vol: 134, Pages: 2165-2170, ISSN: 0013-7227
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- Citations: 44
ZHANG FP, HAMALAINEN T, KAIPIA A, et al., 1994, ONTOGENY OF LUTEINIZING-HORMONE RECEPTOR GENE-EXPRESSION IN THE RAT TESTIS, ENDOCRINOLOGY, Vol: 134, Pages: 2206-2213, ISSN: 0013-7227
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- Citations: 89
HUHTANIEMI I, 1994, ANABOLIC-ANDROGENIC STEROIDS - A DOUBLE-EDGED-SWORD, INTERNATIONAL JOURNAL OF ANDROLOGY, Vol: 17, Pages: 57-62, ISSN: 0105-6263
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- Citations: 8
HUHTANIEMI I, 1994, FETAL TESTIS - A VERY SPECIAL ENDOCRINE ORGAN, EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol: 130, Pages: 25-31, ISSN: 0804-4643
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- Citations: 90
MATIKAINEN T, DELEEUW R, MANNAERTS B, et al., 1994, CIRCULATING BIOACTIVE AND IMMUNOREACTIVE RECOMBINANT HUMAN FOLLICLE-STIMULATING-HORMONE (ORG 32489) AFTER ADMINISTRATION TO GONADOTROPIN-DEFICIENT SUBJECTS, FERTILITY AND STERILITY, Vol: 61, Pages: 62-69, ISSN: 0015-0282
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- Citations: 41
Huhtaniemi I, 1994, [Health risks associated with the use of anabolic steroids]., Duodecim, Vol: 110, Pages: 1020-1028, ISSN: 0012-7183
Huhtaniemi I, Leinonen P, Lähteenmäki P, 1994, [What is new about hormones?]., Duodecim, Vol: 110, Pages: 923-925, ISSN: 0012-7183
Widłak W, Markkula M, Krawczyk Z, et al., 1994, Functional analysis of spermatocyte-specific hst70 gene promoter in transgenic mice., Acta Biochim Pol, Vol: 41, Pages: 103-105, ISSN: 0001-527X
MARKKULA MA, HAMALAINEN TM, ZHANG FP, et al., 1993, THE FSH BETA-SUBUNIT PROMOTER DIRECTS THE EXPRESSION OF HERPES-SIMPLEX VIRUS TYPE-1 THYMIDINE KINASE TO THE TESTIS OF TRANSGENIC MICE, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 96, Pages: 25-36, ISSN: 0303-7207
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- Citations: 18
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