Imperial College London
Alternate

ProfessorIlpoHuhtaniemi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

ilpo.huhtaniemi Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

932 results found

VASANKARI TJ, KUJALA UM, HEINONEN OJ, HUHTANIEMI ITet al., 1993, EFFECTS OF ENDURANCE TRAINING ON HORMONAL RESPONSES TO PROLONGED PHYSICAL EXERCISE IN MALES, ACTA ENDOCRINOLOGICA, Vol: 129, Pages: 109-113, ISSN: 0001-5598

Journal article

PELTOLA V, PARVINEN M, HUHTANIEMI I, KULMALA J, AHOTUPA Met al., 1993, COMPARISON OF EFFECTS OF 0.5 AND 3.0 GY X-IRRADIATION ON LIPID-PEROXIDATION AND ANTIOXIDANT ENZYME FUNCTION IN RAT TESTIS AND LIVER, JOURNAL OF ANDROLOGY, Vol: 14, Pages: 267-274, ISSN: 0196-3635

Journal article

VASANKARI TJ, KUJALA UM, TAIMELA S, HUHTANIEMI ITet al., 1993, PITUITARY-GONADAL RESPONSE TO GONADOTROPIN-RELEASING-HORMONE STIMULATION IS ENHANCED IN MEN AFTER STRENUOUS PHYSICAL EXERCISE, ACTA ENDOCRINOLOGICA, Vol: 129, Pages: 9-14, ISSN: 0001-5598

Journal article

ESKOLA V, NIKULA H, HUHTANIEMI I, 1993, AGE-RELATED VARIATION OF FOLLICLE-STIMULATING HORMONE-STIMULATED CAMP PRODUCTION, PROTEIN-KINASE-C ACTIVITY AND THEIR INTERACTIONS IN THE RAT TESTIS, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 93, Pages: 143-148, ISSN: 0303-7207

Journal article

PERHEENTUPA A, DEJONG F, HUHTANIEMI I, 1993, BIPHASIC EFFECT OF EXOGENOUS TESTOSTERONE ON FOLLICLE-STIMULATING-HORMONE GENE-EXPRESSION AND SYNTHESIS IN THE MALE-RAT, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 93, Pages: 135-141, ISSN: 0303-7207

Journal article

BERGENDAHL M, HUHTANIEMI I, 1993, ACUTE FASTING IS INEFFECTIVE IN SUPPRESSING PITUITARY-GONADAL FUNCTION OF PUBERTAL MALE-RATS, AMERICAN JOURNAL OF PHYSIOLOGY, Vol: 264, Pages: E717-E722, ISSN: 0002-9513

Journal article

PERHEENTUPA A, BERGENDAHL M, DEJONG FH, HUHTANIEMI Iet al., 1993, DIFFERENTIAL REGULATION OF FSH AND INHIBIN GENE-EXPRESSION AND SYNTHESIS BY TESTOSTERONE IN IMMATURE AND MATURE MALE-RATS, JOURNAL OF ENDOCRINOLOGY, Vol: 137, Pages: 69-79, ISSN: 0022-0795

Journal article

HAAVISTO AM, PETTERSSON K, BERGENDAHL M, PERHEENTUPA A, ROSER JF, HUHTANIEMI Iet al., 1993, A SUPERSENSITIVE IMMUNOFLUOROMETRIC ASSAY FOR RAT LUTEINIZING-HORMONE, ENDOCRINOLOGY, Vol: 132, Pages: 1687-1691, ISSN: 0013-7227

Journal article

VASANKARI TJ, RUSKO H, KUJALA UM, HUHTANIEMI ITet al., 1993, THE EFFECT OF SKI TRAINING AT ALTITUDE AND RACING ON PITUITARY, ADRENAL AND TESTICULAR FUNCTION IN MEN, EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY, Vol: 66, Pages: 221-225, ISSN: 0301-5548

Journal article

BLOM T, OJANOTKOHARRI A, LAINE M, HUHTANIEMI Iet al., 1993, METABOLISM OF PROGESTERONE AND TESTOSTERONE IN HUMAN PAROTID AND SUBMANDIBULAR SALIVARY-GLANDS INVITRO, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Vol: 44, Pages: 69-76, ISSN: 0960-0760

Journal article

HUHTANIEMI I, PAKARINEN P, MARKKULA M, ZHANG FP, SOKKA T, HAAVISTO AM, PETTERSSON Ket al., 1993, MOLECULAR ASPECTS IN THE THE ONTOGENY OF GONADOTROPIN SECRETION AND ACTION, 3rd Organon Round Table Conference - GnRH, GnRH Analogs, Gonadotropins and Gonadal Peptides, Publisher: PARTHENON PUBLISHING GROUP LTD, Pages: 357-370

Conference paper

HUHTANIEMI I, MATIKAINEN T, HAAVISTO AM, PETTERSSON Ket al., 1993, RECENT FINDINGS ON THE BIOASSAYS OF GONADOTROPINS, 10TH EUROPEAN CONGRESS OF CLINICAL CHEMISTRY / 12TH NATIONAL MEETING OF THE SOC-FRANCAISE-DE-BIOLOGIE-CLINIQUE ( EUROLAB 93 ), Publisher: JOHN LIBBEY EUROTEXT LTD, Pages: 289-290, ISSN: 0003-3898

Conference paper

Skoblina MN, Matikainen T, Huhtaniemi I, 1993, [The role of cAMP in suppressing the maturation of follicle-enclosed oocytes in the common frog and the clawed toad after their treatment with actinomycin D]., Ontogenez, Vol: 24, Pages: 56-65, ISSN: 0475-1450

During maturation of the follicle-enclosed Rana temporaria and Xenopus laevis oocytes stimulated by pituitary suspension or human chorionic gonadotropin, respectively, the level of cAMP (follicle+medium) increased. When maturation was stimulated by low concentrations of gonadotropic hormones (inducing; however, maturation in 100% or close to 100% cases), the cAMP level increased 1.5-3 fold. Both the increased concentration of gonadotropic hormones and pretreatment of the follicles with actinomycin D stimulated further increase in cAMP level. These treatments in combination led to a significant increase of cAMP and inhibition of oocyte maturation.

Journal article

Sokka TA, Hämäläinen TM, Huhtaniemi IT, 1992, Ontogeny of gonadotropin action in the rat ovary., J Physiol Pharmacol, Vol: 43, Pages: 21-32, ISSN: 0867-5910

Specific binding of radiolabelled FSH and LH to rat ovaries was demonstrated at the age of 7 days. However, when the biological response to LH and FSH was monitored by cAMP production in vitro, the FSH response appeared earlier than that of LH, on days 4 and 7, respectively. Cholera toxin stimulated cAMP production even in fetal ovaries, suggesting the presence of functional post-receptor machinery of cAMP production. Hence, the appearance of the functional gonadotropin receptor probably plays a key role in the onset of postnatal ovarian steroidogenesis. To test the effect of gonadotropin suppression during postnatal ovarian development, a potent GnRH antagonist was administered to neonatal animals between days 1-6 or 1-9 of life. The ovarian responsiveness to FSH developed even in the absence of normal gonadotropin levels, but that to LH was suppressed after the longer antagonist treatment. The temporal relationship between the onset of LHR gene expression, i.e. transcription, and translation to functional receptor protein was thereafter investigated using the reverse transcriptase-polymerase chain reaction (RT-PCR) technique. The measurements revealed the existence only of truncated versions of LHR mRNA in the fetal ovary from day 17 of gestation up to day 7 of postnatal life. With the onset of the receptor function around day 7, also larger mRNA transcripts, corresponding to the full-length receptor protein appeared. Our findings suggest that the LHR gene may be constitutively expressed in the ovary and a change in the alternative splicing pattern may cause the onset of translation of a functional receptor protein.

Journal article

BERGENDAHL M, WIEMANN JN, CLIFTON DK, HUHTANIEMI I, STEINER RAet al., 1992, SHORT-TERM STARVATION DECREASES POMC MESSENGER-RNA BUT DOES NOT ALTER GNRH MESSENGER-RNA IN THE BRAIN OF ADULT MALE-RATS, NEUROENDOCRINOLOGY, Vol: 56, Pages: 913-920, ISSN: 0028-3835

Journal article

HUHTANIEMI I, DING YQ, TAHTELA R, VALIMAKI Met al., 1992, THE BIOIMMUNORATIO OF PLASMA LUTEINIZING-HORMONE DOES NOT CHANGE DURING THE ENDOGENOUS SECRETION PULSE - REANALYSIS OF THE CONCEPT USING IMPROVED IMMUNOMETRIC TECHNIQUES, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 75, Pages: 1442-1445, ISSN: 0021-972X

Journal article

Bergendahl M, Wiemann JN, Clifton DK, Huhtaniemi I, Steiner RAet al., 1992, Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in the brain of adult male rats., Neuroendocrinology, Vol: 56, Pages: 913-920, ISSN: 0028-3835

Dietary restriction reduces circulating gonadotropin and testosterone levels in male rats, an effect thought to be mediated through reduced gonadotropin-releasing hormone (GnRH) secretion; however, the cellular mechanisms subserving this response are still unknown. We reasoned that if dietary restriction reduces GnRH secretion, this would be reflected by a decrease in GnRH synthesis and likewise cellular GnRH mRNA levels. We tested this hypothesis by comparing cellular levels of GnRH mRNA between ad libitum fed (n = 4) and starved (n = 4) adult male rats. Five days of starvation resulted in a 21% decrease in body weight and an 85% decline in serum testosterone levels (fed: 13.9 +/- 2.00 vs. starved: 2.1 +/- 0.70 nmol/l; p < 0.01). In situ hybridization and image analysis demonstrated that short-term starvation influenced neither GnRH cell number (fed: 148 +/- 16 vs. starved: 157 +/- 13 cells) nor cellular GnRH mRNA signal level (fed: 177 +/- 5 vs. starved: 160 +/- 7 grains/cell) in any region of the basal forebrain. Endogenous opioid peptides are known to exert an inhibitory effect on GnRH secretion and have been implicated in having a role in the starvation-induced effects on the reproductive system. We therefore also tested the hypothesis that alterations in proopiomelanocortin (POMC) gene expression are involved in the neuroendocrine response to starvation, by comparing cellular POMC mRNA levels in individual neurons (approximately 160 neurons/animal) of the arcuate and periarcuate nuclei between fed control (n = 4) and starved (n = 4) adult male rats.(ABSTRACT TRUNCATED AT 250 WORDS)

Journal article

PAKARINEN P, HUHTANIEMI I, 1992, AGE-RELATED DISCREPANCIES BETWEEN SERUM AND PITUITARY GONADOTROPIN, AND PITUITARY GONADOTROPIN SUBUNIT MESSENGER-RNA RESPONSES TO CASTRATION AND TESTOSTERONE REPLACEMENT IN MALE-RATS, JOURNAL OF ENDOCRINOLOGY, Vol: 135, Pages: 507-515, ISSN: 0022-0795

Journal article

HUHTANIEMI I, PELLINIEMI LJ, 1992, FETAL LEYDIG-CELLS - CELLULAR-ORIGIN, MORPHOLOGY, LIFE-SPAN, AND SPECIAL FUNCTIONAL FEATURES, PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol: 201, Pages: 125-140, ISSN: 0037-9727

Journal article

PAKARINEN PA, HUHTANIEMI IT, 1992, DEVELOPMENT OF GONADAL FEEDBACK-REGULATION OF GONADOTROPIN GENE-EXPRESSION AND SECRETION IN FEMALE RATS, ACTA ENDOCRINOLOGICA, Vol: 127, Pages: 454-458, ISSN: 0001-5598

Journal article

VUORENTO T, HUHTANIEMI I, 1992, DAILY LEVELS OF SALIVARY PROGESTERONE DURING MENSTRUAL-CYCLE IN ADOLESCENT GIRLS, FERTILITY AND STERILITY, Vol: 58, Pages: 685-690, ISSN: 0015-0282

Journal article

HUHTANIEMI IT, ESKOLA V, PAKARINEN P, MATIKAINEN T, SPRENGEL Ret al., 1992, THE MURINE LUTEINIZING-HORMONE AND FOLLICLE-STIMULATING-HORMONE RECEPTOR GENES - TRANSCRIPTION INITIATION SITES, PUTATIVE PROMOTER SEQUENCES AND PROMOTER ACTIVITY, MOLECULAR AND CELLULAR ENDOCRINOLOGY, Vol: 88, Pages: 55-66, ISSN: 0303-7207

Journal article

PELTOLA V, HUHTANIEMI I, AHOTUPA M, 1992, ANTIOXIDANT ENZYME-ACTIVITY IN THE MATURING RAT TESTIS, JOURNAL OF ANDROLOGY, Vol: 13, Pages: 450-455, ISSN: 0196-3635

Journal article

MATIKAINEN T, DING YQ, VERGARA M, HUHTANIEMI I, COUZINET B, SCHAISON Get al., 1992, DIFFERING RESPONSES OF PLASMA BIOACTIVE AND IMMUNOREACTIVE FOLLICLE-STIMULATING-HORMONE AND LUTEINIZING-HORMONE TO GONADOTROPIN-RELEASING-HORMONE ANTAGONIST AND AGONIST TREATMENTS IN POSTMENOPAUSAL WOMEN, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 75, Pages: 820-825, ISSN: 0021-972X

Journal article

AHOTUPA M, HUHTANIEMI I, 1992, IMPAIRED DETOXIFICATION OF REACTIVE OXYGEN AND CONSEQUENT OXIDATIVE STRESS IN EXPERIMENTALLY CRYPTORCHID RAT TESTIS, BIOLOGY OF REPRODUCTION, Vol: 46, Pages: 1114-1118, ISSN: 0006-3363

Journal article

VUORENTO T, MAENPAA J, HUHTANIEMI I, 1992, FOLLOW-UP OF OVARIAN ENDOCRINE FUNCTION IN PREMENOPAUSAL WOMEN AFTER HYSTERECTOMY BY DAILY MEASUREMENTS OF SALIVARY PROGESTERONE, CLINICAL ENDOCRINOLOGY, Vol: 36, Pages: 505-510, ISSN: 0300-0664

Journal article

SOKKA T, HAMALAINEN T, HUHTANIEMI I, 1992, FUNCTIONAL LH RECEPTOR APPEARS IN THE NEONATAL RAT OVARY AFTER CHANGES IN THE ALTERNATIVE SPLICING PATTERN OF THE LH RECEPTOR MESSENGER-RNA, ENDOCRINOLOGY, Vol: 130, Pages: 1738-1740, ISSN: 0013-7227

Journal article

SALONEN I, PAKARINEN P, HUHTANIEMI I, 1992, EFFECT OF CHRONIC ETHANOL DIET ON EXPRESSION OF GONADOTROPIN GENES IN THE MALE-RAT, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol: 260, Pages: 463-467, ISSN: 0022-3565

Journal article

PETTERSSON K, DING YQ, HUHTANIEMI I, 1992, AN IMMUNOLOGICALLY ANOMALOUS LUTEINIZING-HORMONE VARIANT IN A HEALTHY WOMAN, JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Vol: 74, Pages: 164-171, ISSN: 0021-972X

Journal article

PETTERSSON K, DING YQ, HUHTANIEMI I, 1991, MONOCLONAL ANTIBODY-BASED DISCREPANCIES BETWEEN 2-SITE IMMUNOMETRIC TESTS FOR LUTROPIN, CLINICAL CHEMISTRY, Vol: 37, Pages: 1745-1748, ISSN: 0009-9147

Journal article

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