Imperial College London
Alternate

ProfessorIlpoHuhtaniemi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Reproductive Endocrinology
 
 
 
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Contact

 

ilpo.huhtaniemi Website

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Corona:2014:10.1111/jsm.12327,
author = {Corona, G and Wu, FC and Rastrelli, G and Lee, DM and Forti, G and O'Connor, DB and O'Neill, TW and Pendleton, N and Bartfai, G and Boonen, S and Casanueva, FF and Finn, JD and Huhtaniemi, IT and Kula, K and Punab, M and Vanderschueren, D and Rutter, MK and Maggi, M and EMAS, Study Group},
doi = {10.1111/jsm.12327},
journal = {J Sex Med},
pages = {240--253},
title = {Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS).},
url = {http://dx.doi.org/10.1111/jsm.12327},
volume = {11},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: We previously reported that in male patients consulting for sexual dysfunction, low prolactin (PRL) levels were associated with metabolic syndrome (MetS), arteriogenic erectile dysfunction, and incident major cardiovascular events. AIM: The aim of this study is to assess the clinical associations of PRL levels in the European Male Ageing Study (EMAS). METHODS: EMAS is a prospective, observational cohort of community-dwelling men aged 40-79 years old (mean age 60 ± 11 years old). PRL was available for 2,948 men. MAIN OUTCOME MEASURES: Different parameters were evaluated including the Short Form-36 questionnaire, Becks Depression Inventory, the Adverse Life Events Scale, the Physical Activity Scale for the Elderly, and the EMAS sexual function questionnaire (EMAS-SFQ). RESULTS: After the adjustment for confounders, PRL levels were inversely related with worsening of sexual function as compared with the previous year, as derived from change in sexual functioning domain of the EMAS-SFQ (adj. r = -0.043; P = 0.029). The strongest correlation (Wald = 6.840; P = 0.009) was observed between lower PRL levels and reduced enjoyment of orgasmic experiences. Furthermore, an inverse relationship between PRL levels and stressful life events or depressive symptoms was observed. Low PRL was also negatively associated with an unhealthy metabolic phenotype as well as with the MetS (Wald = 5.229; P = 0.022). In line with these data, low PRL was associated with a lower level of physical activity and feeling unhealthier. CONCLUSIONS: Low PRL is related to several metabolic, psychological, and sexual unhealthy characteristics in European men. Checking PRL might be useful to stratify men for cardiovascular risk and to encourage appropriate lifestyle changes.
AU  - Corona,G
AU  - Wu,FC
AU  - Rastrelli,G
AU  - Lee,DM
AU  - Forti,G
AU  - O'Connor,DB
AU  - O'Neill,TW
AU  - Pendleton,N
AU  - Bartfai,G
AU  - Boonen,S
AU  - Casanueva,FF
AU  - Finn,JD
AU  - Huhtaniemi,IT
AU  - Kula,K
AU  - Punab,M
AU  - Vanderschueren,D
AU  - Rutter,MK
AU  - Maggi,M
AU  - EMAS,Study Group
DO  - 10.1111/jsm.12327
EP  - 253
PY  - 2014///
SP  - 240
TI  - Low prolactin is associated with sexual dysfunction and psychological or metabolic disturbances in middle-aged and elderly men: the European Male Aging Study (EMAS).
T2  - J Sex Med
UR  - http://dx.doi.org/10.1111/jsm.12327
UR  - https://www.ncbi.nlm.nih.gov/pubmed/24345293
VL  - 11
ER  -
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