Professor Mitchell completed a PhD in Pharmacology with Sir Professor John R Vane (FRS, Nobel Laureate) and Dr Gilberto De Nucci 1990 before joining Professor Ferid Murad (NAS USA, Nobel Laureate) as a fellow of Northwestern University (Chicago, USA) for her postdoctoral training in the biochemistry of nitric oxide synthase. She returned to work with John Vane on the pharmacology of cyclo-oxygenase isoforms before joining the group of Professor Timothy Williams at the National Heart and Lung Institute, now part of Imperial College.
Professor Mitchell was awarded a Wellcome Trust Career Development Fellowship in 1997 and the Novartis Prize for Pharmacology in 1999 for her contribution to the field of cyclo-oxygeanse biology. Since this time, Professor Mitchell has led her own group - Cardiothoracic Pharmacology - consisting of academics, clinicians, postdoctoral fellows and undergraduate/postgraduate students.
Professor Mitchell is amongst the top 1% of cited pharmacologists world-wide and as such, is a member of Thomson Scientific Highlycited listings (isihighlycited.com) with more than 150 publications in peer reviewed journals.
Professor Mitchell was awarded the 2009 Rector’s Award for Excellence in Research Supervision and Elected Research Supervision Fellow.
Professor Mitchell was awarded the AstraZeneca Women in Pharmacology Prize in 2012. She talks about receiving the award here.
et al., A bioassay system of autologous human endothelial, smooth muscle cells and leucocytes for use in drug discovery, phenotyping and tissue engineering, The Faseb Journal, ISSN:0892-6638
et al., 2019, Mechanistic definition of the cardiovascular mPGES-1/COX-2/ADMA axis, Cardiovascular Research, ISSN:0008-6363
et al., 2019, Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox, Circulation Research, Vol:125, ISSN:0009-7330, Pages:847-854
George PM, Mitchell JA, 2019, Defining a pathological role for the vasculature in the development of fibrosis and pulmonary hypertension in interstitial lung disease, American Journal of Physiology-lung Cellular and Molecular Physiology, Vol:317, ISSN:1040-0605, Pages:L431-L433
et al., 2019, A bioassay system of autologous human endothelial and smooth muscle cells for use in cardiovascular drug discovery and patient phenotyping, British-Pharmacology-Society Meeting (Pharmacology), WILEY, Pages:3040-3041, ISSN:0007-1188