Imperial College London

Dr John Baksi

Faculty of MedicineNational Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7352 8121j.baksi

 
 
//

Location

 

Cardiovascular MR UnitRoyal Brompton Campus

//

Summary

 

Publications

Publication Type
Year
to

44 results found

Halliday BP, Chiew K, Newsome S, Wassall R, Lota A, Tayal U, Jackson R, Rahneva T, Baksi AJ, Cleland JG, Prasad SKet al., 2017, Incremental prognostic value of cardiopulmonary exercise testing in non-ischemic dilated cardiomyopathy, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 19, Pages: 435-435, ISSN: 1388-9842

JOURNAL ARTICLE

Rea G, Homfray T, Till J, Roses-Noguer F, Buchan RJ, Wilkinson S, Wilk A, Walsh R, John S, McKee S, Stewart FJ, Murday V, Taylor RW, Ashworth M, Baksi AJ, Daubeney P, Prasad S, Barton PJR, Cook SA, Ware JSet al., 2017, Histiocytoid cardiomyopathy and microphthalmia with linear skin defects syndrome: phenotypes linked by truncating variants in NDUFB11., Cold Spring Harb Mol Case Stud, Vol: 3, ISSN: 2373-2873

Variants in NDUFB11, which encodes a structural component of complex I of the mitochondrial respiratory chain (MRC), were recently independently reported to cause histiocytoid cardiomyopathy (histiocytoid CM) and microphthalmia with linear skin defects syndrome (MLS syndrome). Here we report an additional case of histiocytoid CM, which carries a de novo nonsense variant in NDUFB11 (ENST00000276062.8: c.262C > T; p.[Arg88*]) identified using whole-exome sequencing (WES) of a family trio. An identical variant has been previously reported in association with MLS syndrome. The case we describe here lacked the diagnostic features of MLS syndrome, but a detailed clinical comparison of the two cases revealed significant phenotypic overlap. Heterozygous variants in HCCS (which encodes an important mitochondrially targeted protein) and COX7B, which, like NDUFB11, encodes a protein of the MRC, have also previously been identified in MLS syndrome including a case with features of both MLS syndrome and histiocytoid CM. However, a systematic review of WES data from previously published histiocytoid CM cases, alongside four additional cases presented here for the first time, did not identify any variants in these genes. We conclude that NDUFB11 variants play a role in the pathogenesis of both histiocytoid CM and MLS and that these disorders are allelic (genetically related).

JOURNAL ARTICLE

Tayal U, Newsome S, Buchan R, Whiffin N, Halliday B, Lota A, Roberts A, Baksi AJ, Voges I, Midwinter W, Wilk A, Govind R, Walsh R, Daubeney P, Jarman JWE, Baruah R, Frenneaux M, Barton PJ, Pennell D, Ware JS, Prasad SK, Cook SAet al., 2017, Phenotype and Clinical Outcomes of Titin Cardiomyopathy, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 70, Pages: 2264-2274, ISSN: 0735-1097

JOURNAL ARTICLE

Alam MH, Auger D, McGill L-A, Smith GC, He T, Izgi C, Baksi AJ, Wage R, Drivas P, Firmin DN, Pennell DJet al., 2016, Comparison of 3 T and 1.5 T for T2*magnetic resonance of tissue iron, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 18, ISSN: 1097-6647

JOURNAL ARTICLE

Baksi AJ, Davies JE, Hadjiloizou N, Baruah R, Unsworth B, Foale RA, Korolkova O, Siggers JH, Francis DP, Mayet J, Parker KH, Hughes ADet al., 2016, Attenuation of reflected waves in man during retrograde propagation from femoral artery to proximal aorta, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 202, Pages: 441-445, ISSN: 0167-5273

JOURNAL ARTICLE

Izgi C, Vassiliou V, Baksi AJ, Prasad SKet al., 2016, Differential diagnosis of left ventricular hypertrophy: usefulness of multimodality imaging and tissue characterization with cardiac magnetic resonance, ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES, Vol: 33, Pages: 1765-1768, ISSN: 0742-2822

JOURNAL ARTICLE

Pennell DJ, Baksi AJ, Prasad SK, Mohiaddin RH, Alpendurada F, Babu-Narayan SV, Schneider JE, Firmin DNet al., 2016, Review of Journal of Cardiovascular Magnetic Resonance 2015, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 18, ISSN: 1097-6647

JOURNAL ARTICLE

Rea G, Homfray T, Till J, Roses-Noguer F, Buchan RJ, Wilkinson S, Walsh R, McKee S, Stewart FJ, Murday V, Taylor RW, Baksi AJ, Prasad SK, Barton PJR, Ware JS, Cook SAet al., 2016, WHOLE EXOME SEQUENCING IDENTIFIES GENETIC CAUSE OF HISTIOCYTOID CARDIOMYOPATHY, Annual Conference of the British-Cardiovascular-Society (BCS) on Prediction and Prevention, Publisher: BMJ PUBLISHING GROUP, Pages: A138-A139, ISSN: 1355-6037

CONFERENCE PAPER

Rea G, Ware JS, Homfray T, Till J, Roses-Noguer F, Buchan R, Wilkinson S, Wilk A, Walsh R, John S, McKee S, Stewart FJ, Murday V, Taylor RW, Baksi AJ, Daubeney P, Prasad S, Barton PJR, Cook SAet al., 2016, HISTIOCYTOID CARDIOMYOPATHY AND MICROPHTHALMIA WITH LINEAR SKIN DEFECTS SYNDROME: PHENOTYPES LINKED BY TRUNCATING VARIANTS IN NDUFB11, Annual Meeting of the British-Congenital-Cardiac-Association, Publisher: BMJ PUBLISHING GROUP, Pages: A18-A18, ISSN: 1355-6037

CONFERENCE PAPER

Alam MH, Auger D, Smith GC, He T, Vassiliou V, Baksi AJ, Wage R, Drivas P, Feng Y, Firmin DN, Pennell DJet al., 2015, T1 at 1.5T and 3T compared with conventional T2*at 1.5T for cardiac siderosis, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 17, ISSN: 1097-6647

JOURNAL ARTICLE

Baksi AJ, Kanaganayagam GS, Prasad SK, 2015, Arrhythmias in viral myocarditis and pericarditis., Card Electrophysiol Clin, Vol: 7, Pages: 269-281

Acute viral myocarditis and acute pericarditis are self-limiting conditions that run a benign course and that may not involve symptoms that lead to medical assessment. However, ventricular arrhythmia is frequent in viral myocarditis. Myocarditis is thought to account for a large proportion of sudden cardiac deaths in young people without prior structural heart disease. Identification of acute myocarditis either with or without pericarditis is therefore important. However, therapeutic interventions are limited and nonspecific. Identifying those at greatest risk of a life-threatening arrhythmia is critical to reducing the mortality. This review summarizes current understanding of this challenging area in which many questions remain.

JOURNAL ARTICLE

Baksi AJ, Pennell DJ, 2015, Cardiomyopathy, Advanced Cardiac Imaging, Pages: 399-438, ISBN: 9781782422945

BOOK CHAPTER

Izgi C, Ray S, Nyktari E, Alpendurada F, Lyon AR, Rathore S, Baksi AJet al., 2015, Myocardial edema in Takotsubo syndrome mimicking apical hypertrophic cardiomyopathy: An insight into diagnosis by cardiovascular magnetic resonance, HEART & LUNG, Vol: 44, Pages: 481-485, ISSN: 0147-9563

JOURNAL ARTICLE

Pennell DJ, Baksi AJ, Prasad SK, Raphael CE, Kilner PJ, Mohiaddin RH, Alpendurada F, Babu-Narayan SV, Schneider J, Firmin DNet al., 2015, Review of Journal of Cardiovascular Magnetic Resonance 2014, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 17, ISSN: 1097-6647

JOURNAL ARTICLE

Venneri L, Calicchio F, Manivarmane R, Baksi AJ, Rosen SD, Senior R, Lyon AR, Khattar RSet al., 2015, Impaired myocardial function despite normal ejection fraction in patients on current cancer drug therapies, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 150-150, ISSN: 0195-668X

CONFERENCE PAPER

Baksi AJ, Pennell DJ, 2014, T2* imaging of the heart: methods, applications, and outcomes., Top Magn Reson Imaging, Vol: 23, Pages: 13-20

This review describes and discusses the rationale, technique, applications, and impact of cardiovascular magnetic resonance (CMR) T2* imaging, principally in the assessment of iron loading within the heart, and highlights how this robust imaging strategy has transformed disease outcome.Until recently, no simple noninvasive measurement was available to reliably indicate severe cardiac iron loading before the development of overt cardiac dysfunction or heart failure. Consequently, the majority of patients with transfusion-dependent anemias, such as β-thalassemia major, died prematurely of cardiovascular complications of severe iron overload.The magnetic properties of particulate iron disrupt magnetic field homogeneity in the CMR environment and consequently influence the CMR parameter T2*, which describes signal decay relating to both field inhomogeneity and loss of spin coherence. There is a direct relationship between T2* and myocardial iron concentration, enabling this to be used to identify and quantify myocardial iron load. Single breath-hold gradient-echo sequences in which a single midventricular short-axis myocardial slice is acquired at multiple echo times enables a myocardial T2* value to be measured from the rate of exponential decay. The application of T2* CMR to assessing cardiac iron loading is rapid, reproducible, extensively validated, and now widely performed. Data have highlighted the profound predictive power of this imaging technique and moreover its ability to inform management strategies such that, over a relatively short duration, outcome has been dramatically improved, and the disease course in β-thalassemia major transformed.

JOURNAL ARTICLE

Baksi AJ, Pennell DJ, 2014, Randomized controlled trials of iron chelators for the treatment of cardiac siderosis in thalassaemia major, FRONTIERS IN PHARMACOLOGY, Vol: 5, ISSN: 1663-9812

JOURNAL ARTICLE

Barron AJ, Hughes AD, Sharp A, Baksi AJ, Surendran P, Jabbour RJ, Stanton A, Poulter N, Fitzgerald D, Sever P, O'Brien E, Thom S, Mayet Jet al., 2014, Long-Term Antihypertensive Treatment Fails to Improve E/e ' Despite Regression of Left Ventricular Mass An Anglo-Scandinavian Cardiac Outcomes Trial Substudy, HYPERTENSION, Vol: 63, Pages: 252-+, ISSN: 0194-911X

JOURNAL ARTICLE

Carpenter J-P, He T, Kirk P, Roughton M, Anderson LJ, de Noronha SV, Baksi AJ, Sheppard MN, Porter JB, Walker JM, Wood JC, Forni G, Catani G, Matta G, Fucharoen S, Fleming A, House M, Black G, Firmin DN, St Pierre TG, Pennell DJet al., 2014, Calibration of myocardial T2 and T1 against iron concentration, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 16, ISSN: 1097-6647

JOURNAL ARTICLE

Pennell DJ, Baksi AJ, Kilner PJ, Mohiaddin RH, Prasad SK, Alpendurada F, Babu-Narayan SV, Neubauer S, Firmin DNet al., 2014, Review of Journal of Cardiovascular Magnetic Resonance 2013, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 16, ISSN: 1097-6647

JOURNAL ARTICLE

Petryka J, Baksi AJ, Prasad SK, Pennell DJ, Kilner PJet al., 2014, Prevalence of Inferobasal Myocardial Crypts Among Patients Referred for Cardiovascular Magnetic Resonance, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 7, Pages: 259-264, ISSN: 1941-9651

JOURNAL ARTICLE

Raphael CE, Baksi AJ, Alpendurada F, Mitchell F, Vassiliou V, Ali A, Prasad SK, Pennell DJ, Mohiaddin RHet al., 2014, Cardiovascular magnetic resonance in patients with MRI-conditional pacemakers: a single centre experience, Congress of the European-Society-of-Cardiology (ESC), Publisher: OXFORD UNIV PRESS, Pages: 798-799, ISSN: 0195-668X

CONFERENCE PAPER

Baksi AJ, Pennell DJ, 2013, T1 Mapping in Heart Failure From Technique to Prognosis, Toward Altering Outcome, CIRCULATION-CARDIOVASCULAR IMAGING, Vol: 6, Pages: E58-E60, ISSN: 1941-9651

JOURNAL ARTICLE

Gulati A, Ismail TF, Jabbour A, Ismail NA, Morarji K, Ali A, Raza S, Khwaja J, Brown TDH, Liodakis E, Baksi AJ, Shakur R, Guha K, Roughton M, Wage R, Cook SA, Alpendurada F, Assomull RG, Mohiaddin RH, Cowie MR, Pennell DJ, Prasad SKet al., 2013, Clinical utility and prognostic value of left atrial volume assessment by cardiovascular magnetic resonance in non-ischaemic dilated cardiomyopathy, EUROPEAN JOURNAL OF HEART FAILURE, Vol: 15, Pages: 660-670, ISSN: 1388-9842

JOURNAL ARTICLE

O'Regan DP, Ariff B, Baksi AJ, Gordon F, Durighel G, Cook SAet al., 2013, Salvage assessment with cardiac MRI following acute myocardial infarction underestimates potential for recovery of systolic strain, EUROPEAN RADIOLOGY, Vol: 23, Pages: 1210-1217, ISSN: 0938-7994

JOURNAL ARTICLE

Pennell DJ, Baksi AJ, Carpenter JP, Firmin DN, Kilner PJ, Mohiaddin RH, Prasad SKet al., 2013, Review of Journal of Cardiovascular Magnetic Resonance 2012, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 15, ISSN: 1097-6647

JOURNAL ARTICLE

Gulati A, Ismail N, Ismail T, Ali A, Liodakis E, Morarji K, Guha K, Baksi AJ, Krishnathasan K, Roughton M, Pakrashi T, Alpendurada F, Jabbour A, Pennell DJ, Prasad SKet al., 2012, Left Atrial Volume Provides Independent and Incremental Prognostic Information in Non-Ischemic Dilated Cardiomyopathy, CIRCULATION, Vol: 126, ISSN: 0009-7322

JOURNAL ARTICLE

O'Regan DP, Shi W, Ariff B, Baksi AJ, Durighel G, Rueckert D, Cook SAet al., 2012, Remodeling after acute myocardial infarction: mapping ventricular dilatation using three dimensional CMR image registration, JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, Vol: 14, ISSN: 1097-6647

JOURNAL ARTICLE

Baksi AJ, 2011, Common academic pitfalls., Secrets of Success: Getting into Academic Medicine., Editors: Smith, Gill, Nijjer, Levy, London, Publisher: RSM Books; Hodder Arnold, ISBN: 978-1853159572

BOOK CHAPTER

Baksi AJ, Davies JE, Hadjiloizou N, Baruah R, Unsworth B, Foale RA, Parker KH, Francis DP, Mayet J, Hughes ADet al., 2011, Backward Propagation of Waves is Limited in the Human Arterial Tree, CIRCULATION, Vol: 124, ISSN: 0009-7322

JOURNAL ARTICLE

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: respub-action=search.html&id=00236810&limit=30&person=true