Imperial College London
Alternate

Dr John Baksi

Faculty of Medicine, National Heart & Lung Institute

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

j.baksi

 
 
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Location

 

Cardiovascular MR UnitRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Baksi:2014:10.1097/RMR.0000000000000011,
author = {Baksi, AJ and Pennell, DJ},
doi = {10.1097/RMR.0000000000000011},
journal = {Top Magn Reson Imaging},
pages = {13--20},
title = {T2* imaging of the heart: methods, applications, and outcomes.},
url = {http://dx.doi.org/10.1097/RMR.0000000000000011},
volume = {23},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - This review describes and discusses the rationale, technique, applications, and impact of cardiovascular magnetic resonance (CMR) T2 imaging, principally in the assessment of iron loading within the heart, and highlights how this robust imaging strategy has transformed disease outcome.Until recently, no simple noninvasive measurement was available to reliably indicate severe cardiac iron loading before the development of overt cardiac dysfunction or heart failure. Consequently, the majority of patients with transfusion-dependent anemias, such as β-thalassemia major, died prematurely of cardiovascular complications of severe iron overload.The magnetic properties of particulate iron disrupt magnetic field homogeneity in the CMR environment and consequently influence the CMR parameter T2, which describes signal decay relating to both field inhomogeneity and loss of spin coherence. There is a direct relationship between T2 and myocardial iron concentration, enabling this to be used to identify and quantify myocardial iron load. Single breath-hold gradient-echo sequences in which a single midventricular short-axis myocardial slice is acquired at multiple echo times enables a myocardial T2 value to be measured from the rate of exponential decay. The application of T2 CMR to assessing cardiac iron loading is rapid, reproducible, extensively validated, and now widely performed. Data have highlighted the profound predictive power of this imaging technique and moreover its ability to inform management strategies such that, over a relatively short duration, outcome has been dramatically improved, and the disease course in β-thalassemia major transformed.
AU  - Baksi,AJ
AU  - Pennell,DJ
DO  - 10.1097/RMR.0000000000000011
EP  - 20
PY  - 2014///
SP  - 13
TI  - T2 imaging of the heart: methods, applications, and outcomes.
T2  - Top Magn Reson Imaging
UR  - http://dx.doi.org/10.1097/RMR.0000000000000011
UR  - https://www.ncbi.nlm.nih.gov/pubmed/24509620
VL  - 23
ER  -
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