Imperial College London

ProfessorJackiede Belleroche

Faculty of MedicineDepartment of Medicine




+44 (0)20 7594 6649j.belleroche




Dr Jennifer Halton +44 (0)20 7594 6545




E407Burlington DanesHammersmith Campus





Our research group has a strong commitment to research on Amyotrophic Lateral sclerosis (ALS) through molecular genetics, expression profiling in spinal cord and through the use of experimental models to develop new therapeutic approaches. Our major goal has been to identify disease genes associated with the dominantly inherited familial form of ALS (FALS) which, although rare, accounting for 5% of cases, is clinically indistinguishable from the sporadic form of the disease. In order to do this, we have established a resource of ~ 200 families. To date, mutations have been identified in ~70% of these families. The most recently identified mutations causing ALS, frontotemporal dementia (FTD) or ALS/FTD are large hexanucleotide repeat expansions found in a gene of unknown function, C9ORF72), which  account for 38% of familial cases of ALS and 6% of sporadic cases in the UK and is characterised by TDP-43-positive ubiquitinated inclusions, the typical hallmark of sporadic cases. Our group has also made key contributions to understanding the role of the small heat shock protein, HSP27 (HSPB1) in the mammalian brain and spinal cord, from the characterisation of the expression of HSPs in stroke and seizures to the demonstration that HSP27 can reduce seizures, attenuate caspase 3 induction and protect against hippocampal cell death. Furthermore, we showed that HSP27 rescues motor neurones and preserves muscle function following injury.

Membership of External Committees.

Member of the Motor Neurone Disease Association Research Advisory Panel (2009-)

International Scientific Committee. Agency for Research on Amyotrophic Lateral Sclerosis (2009-)

Member of the Council of the European Society for Neurochemistry

International Programme Committee for the International Society of Neurochemistry, Busan, South Korea August 2009.


Fellow of the Royal College of Pathologists 1996-

Fellow of the Society of Biology 2011-



de Belleroche JS, Samali A, Chevet E, et al., Endoplasmic Reticulum Stress signalling – from basic mechanisms to clinical applications, The Febs Journal

Kondori NR, Paul P, Robbins JP, et al., 2018, Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS)., Front Mol Biosci, Vol:5, ISSN:2296-889X

Montibeller L, de Belleroche J, 2018, Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genes., Cell Stress Chaperones

Nicolas A, Kenna KP, Renton AE, et al., 2018, Genome-wide Analyses Identify KIF5A as a Novel ALS Gene, Neuron, Vol:97, ISSN:0896-6273, Pages:1268-+

de Majo M, Topp SD, Smith BN, et al., 2018, ALS-associated missense and nonsense TBK1 mutations can both cause loss of kinase function, Neurobiology of Aging, ISSN:0197-4580

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