Imperial College London

DrJanineBosse

Faculty of MedicineDepartment of Infectious Disease

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 1803j.bosse

 
 
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Location

 

234Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

73 results found

Bosse JT, MacInnes JI, 2000, Urease activity may contribute to the ability of Actinobacillus pleuropneumoniae to establish infection, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, Vol: 64, Pages: 145-150, ISSN: 0830-9000

Journal article

Bosse JT, MacInnes JI, 1997, Genetic and biochemical analyses of Actinobacillus pleuropneumoniae urease, INFECTION AND IMMUNITY, Vol: 65, Pages: 4389-4394, ISSN: 0019-9567

Journal article

Magnusson U, Bosse J, Mallard BA, Rosendal S, Wilkie BNet al., 1997, Antibody response to Actinobacillus pleuropneumoniae antigens after vaccination of pigs bred for high and low immune response, VACCINE, Vol: 15, Pages: 997-1000, ISSN: 0264-410X

Journal article

Furesz SE, Mallard BA, Bosse JT, Rosendal S, Wilkie BN, Macinnes JIet al., 1997, Antibody- and cell-mediated immune responses of Actinobacillus pleuropneumoniae-infected and bacterin-vaccinated pigs, INFECTION AND IMMUNITY, Vol: 65, Pages: 358-365, ISSN: 0019-9567

Journal article

FREY J, BOSSE JT, CHANG YF, CULLEN JM, FENWICK B, GERLACH GF, GYGI D, HAESEBROUCK F, INZANA TJ, JANSEN R, KAMP EM, MACDONALD J, MACINNES JI, MITTAL KR, NICOLET J, RYCROFT AN, SEGERS R, SMITS MA, STENBAEK E, STRUCK DK, VANDENBOSCH JF, WILLSON PJ, YOUNG Ret al., 1993, ACTINOBACILLUS-PLEUROPNEUMONIAE RTX-TOXINS - UNIFORM DESIGNATION OF HEMOLYSINS, CYTOLYSINS, PLEUROTOXIN AND THEIR GENES, JOURNAL OF GENERAL MICROBIOLOGY, Vol: 139, Pages: 1723-1728, ISSN: 0022-1287

Journal article

BOSSE JT, FRIENDSHIP R, ROSENDAL S, FENWICK BWet al., 1993, DEVELOPMENT AND EVALUATION OF A MIXED-ANTIGEN ELISA FOR SERODIAGNOSIS OF ACTINOBACILLUS-PLEUROPNEUMONIAE SEROTYPES 1, 5, AND 7 INFECTIONS IN COMMERCIAL SWINE HERDS, JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, Vol: 5, Pages: 359-362, ISSN: 1040-6387

Journal article

BOSSE JT, JOHNSON RP, NEMEC M, ROSENDAL Set al., 1992, PROTECTIVE LOCAL AND SYSTEMIC ANTIBODY-RESPONSES OF SWINE EXPOSED TO AN AEROSOL OF ACTINOBACILLUS-PLEUROPNEUMONIAE SEROTYPE-1, INFECTION AND IMMUNITY, Vol: 60, Pages: 479-484, ISSN: 0019-9567

Journal article

GARDNER IA, BOSSE JT, SHELDRAKE RF, ROSENDAL S, JOHNSON RPet al., 1991, SEROLOGICAL RESPONSE TO ACTINOBACILLUS-PLEUROPNEUMONIAE SEROVAR-7 INFECTION IN A COMMERCIAL PIG HERD, AUSTRALIAN VETERINARY JOURNAL, Vol: 68, Pages: 349-352, ISSN: 0005-0423

Journal article

DEVENISH J, ROSENDAL S, BOSSE JT, 1990, HUMORAL ANTIBODY-RESPONSE AND PROTECTIVE IMMUNITY IN SWINE FOLLOWING IMMUNIZATION WITH THE 104-KILODALTON HEMOLYSIN OF ACTINOBACILLUS-PLEUROPNEUMONIAE, INFECTION AND IMMUNITY, Vol: 58, Pages: 3829-3832, ISSN: 0019-9567

Journal article

BOSSE JT, JOHNSON RP, ROSENDAL S, 1990, SERODIAGNOSIS OF PLEUROPNEUMONIA USING ENZYME-LINKED-IMMUNOSORBENT-ASSAY WITH CAPSULAR POLYSACCHARIDE ANTIGENS OF ACTINOBACILLUS-PLEUROPNEUMONIAE SEROTYPES 1, 2, 5 AND 7, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, Vol: 54, Pages: 427-431, ISSN: 0830-9000

Journal article

BOSSE JT, JOHNSON RP, ROSENDAL S, 1990, CAPSULAR POLYSACCHARIDE ANTIGENS FOR DETECTION OF SEROTYPE-SPECIFIC ANTIBODIES TO ACTINOBACILLUS-PLEUROPNEUMONIAE, CANADIAN JOURNAL OF VETERINARY RESEARCH-REVUE CANADIENNE DE RECHERCHE VETERINAIRE, Vol: 54, Pages: 320-325, ISSN: 0830-9000

Journal article

DEVENISH J, ROSENDAL S, BOSSE JT, WILKIE BN, JOHNSON Ret al., 1990, PREVALENCE OF SEROREACTORS TO THE 104-KILODALTON HEMOLYSIN OF ACTINOBACILLUS-PLEUROPNEUMONIAE IN SWINE HERDS, JOURNAL OF CLINICAL MICROBIOLOGY, Vol: 28, Pages: 789-791, ISSN: 0095-1137

Journal article

Bossé JT, Li Y, Leanse LG, Zhou L, Chaudhuri RR, Peters SE, Wang J, Maglennon GA, Holden MTG, Maskell DJ, Tucker AW, Wren BW, Rycroft AN, Langford PRet al., Rationally designed mariner vectors to allow functional genomic analysis of Actinobacillus pleuropneumoniae and other bacteria by transposon-directed insertion-site sequencing (TraDIS)

<jats:title>Abstract</jats:title><jats:p>Transposon Directed Insertion Sequencing (TraDIS) is a high-throughput method for mapping insertion sites in large libraries of transposon mutants. The <jats:italic>Himar1</jats:italic> (<jats:italic>mariner</jats:italic>) transposon is ideal for generating near-saturating mutant libraries, especially in AT-rich chromosomes, as the requirement for integration is a TA dinucleotide. In this study, we generated two novel <jats:italic>mariner</jats:italic> vectors, pTsodCPC9 and pTlacPC9 (differing only in the promoter driving expression of the transposase gene), in order to facilitate TraDIS identification of conditionally essential genes in <jats:italic>Actinobacillus pleuropneumoniae</jats:italic> and other bacteria. Using the pTlacPC9 vector, we have generated, for the first time, saturating <jats:italic>mariner</jats:italic> mutant libraries in both <jats:italic>A. pleuropneumoniae</jats:italic> and <jats:italic>Pasteurella multocida</jats:italic> that showed a near random distribution of insertions around the respective chromosomes. A preliminary screen of 5000 mutants each identified 8 and 15 genes, respectively, that are required for growth under anaerobic conditions.</jats:p>

Journal article

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