Imperial College London

DrJanineBosse

Faculty of MedicineDepartment of Infectious Disease

Senior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 1803j.bosse

 
 
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Location

 

234Wright Fleming WingSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brockmeier:2018:10.1128/IAI.00559-17,
author = {Brockmeier, SL and Loving, CL and Nicholson, TL and Wang, J and Peters, SE and Weinert, L and Chaudhuri, R and Seilly, DJ and Langford, PR and Rycroft, A and Wren, BW and Maskell, DJ and Tucker, AW and BRADP1T, Consortium},
doi = {10.1128/IAI.00559-17},
journal = {Infection and Immunity},
title = {Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs},
url = {http://dx.doi.org/10.1128/IAI.00559-17},
volume = {86},
year = {2018}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Streptococcus suis is a bacterium commonly carried in the respiratory tract that is also one of the most important invasive pathogens of swine, commonly causing meningitis, arthritis, and septicemia. Due to the existence of many serotypes and a wide range of immune evasion capabilities efficacious vaccines are not readily available. The selection of S. suis protein candidates for inclusion in a vaccine was accomplished by identifying fitness genes through a functional genomics screen and selecting conserved predicted surface-associated proteins. Five candidate proteins were selected for evaluation in a vaccine trial and administered both intranasally and intramuscularly with one of two different adjuvant formulations. Clinical protection was evaluated by subsequent intranasal challenge with virulent S. suis While subunit vaccination with the S. suis proteins induced IgG antibody titers to each individual protein, a cellular immune response to the pool of proteins, and provided substantial protection from challenge with virulent S. suis, the immune response elicited and degree of protection were dependent on the parenteral adjuvant given. Subunit vaccination induced IgG reactive against different S. suis serotypes indicating a potential for cross-protection.
AU - Brockmeier,SL
AU - Loving,CL
AU - Nicholson,TL
AU - Wang,J
AU - Peters,SE
AU - Weinert,L
AU - Chaudhuri,R
AU - Seilly,DJ
AU - Langford,PR
AU - Rycroft,A
AU - Wren,BW
AU - Maskell,DJ
AU - Tucker,AW
AU - BRADP1T,Consortium
DO - 10.1128/IAI.00559-17
PY - 2018///
SN - 0019-9567
TI - Use of proteins identified through a functional genomic screen to develop a protein subunit vaccine that provides significant protection against virulent Streptococcus suis in pigs
T2 - Infection and Immunity
UR - http://dx.doi.org/10.1128/IAI.00559-17
UR - http://hdl.handle.net/10044/1/56413
VL - 86
ER -