Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Senior Research Fellow



+44 (0)20 7594 1803j.bosse




234Wright Fleming WingSt Mary's Campus






BibTex format

author = {Michael, G and Bosse, J and Schwarz, S},
doi = {10.1128/microbiolspec.ARBA-0022-2017},
journal = {Microbiology Spectrum},
pages = {1--33},
title = {Antimicrobial resistance in pasteurellaceae of veterinary origin},
url = {},
volume = {6},
year = {2018}

RIS format (EndNote, RefMan)

AB - Members of the highly heterogeneous family Pasteurellaceae cause a wide variety of diseases in humans and animals. Antimicrobial agents are the most powerful tools to control such infections. However, the acquisition of resistance genes, as well as the development of resistance-mediating mutations, significantly reduces the efficacy of the antimicrobial agents. This article gives a brief description of the role of selected members of the family Pasteurellaceae in animal infections and of the most recent data on the susceptibility status of such members. Moreover, a review of the current knowledge of the genetic basis of resistance to antimicrobial agents is included, with particular reference to resistance to tetracyclines, β-lactam antibiotics, aminoglycosides/aminocyclitols, folate pathway inhibitors, macrolides, lincosamides, phenicols, and quinolones. This article focusses on the genera of veterinary importance for which sufficient data on antimicrobial susceptibility and the detection of resistance genes are currently available (Pasteurella, Mannheimia, Actinobacillus, Haemophilus, and Histophilus). Additionally, the role of plasmids, transposons, and integrative and conjugative elements in the spread of the resistance genes within and beyond the aforementioned genera is highlighted to provide insight into horizontal dissemination, coselection, and persistence of antimicrobial resistance genes. The article discusses the acquisition of diverse resistance genes by the selected Pasteurellaceae members from other Gram-negative or maybe even Gram-positive bacteria. Although the susceptibility status of these members still looks rather favorable, monitoring of their antimicrobial susceptibility is required for early detection of changes in the susceptibility status and the newly acquired/developed resistance mechanisms.
AU - Michael,G
AU - Bosse,J
AU - Schwarz,S
DO - 10.1128/microbiolspec.ARBA-0022-2017
EP - 33
PY - 2018///
SN - 2165-0497
SP - 1
TI - Antimicrobial resistance in pasteurellaceae of veterinary origin
T2 - Microbiology Spectrum
UR -
UR -
VL - 6
ER -