Imperial College London

Dr James A Bull

Faculty of Natural SciencesDepartment of Chemistry

Reader in Synthetic Chemistry



+44 (0)20 7594 5811j.bull Website




501bMolecular Sciences Research HubWhite City Campus





Dr James A Bull is a Royal Society University Research Fellow in the Department of Chemistry.

Dr Bull’s research focuses on the development of efficient synthetic and catalytic methods to access novel structural motifs and heterocycles of interest in drug discovery.


James is awarded the 2021 AstraZeneca Prize for Synthetic Chemistry, as covered in this Chemistry World article.

For group news, see: @jamesabull

          *** PhD Studentships available - 2022 Entry ***

We will have a fully funded industry sponsored studentship available in the group for Oct 2022 start (more details available from November 2021). Interested candidates should get in touch by email.

We will be offering additional funded projects through the REact CDT for Oct 2022:

Biographical details

James Bull graduated from the University of Cambridge in 2001 with a First Class Honours MSci degree in Natural Sciences, Chemistry and the Raphael Prize for Organic Chemistry. He then spent a year working at GlaxoSmithKline Stevenage as a Research Scientist in the Medicinal Chemistry Department.

He returned to Cambridge in 2003 to undertake PhD research with Professor Steven V Ley. He completed the total synthesis of bisoxazole antifungal natural product bengazole A and analogues.

In 2007 he joined the group of Professor André B. Charette as a Postdoctoral Fellow at Université de Montréal, Canada. Here he developed an intramolecular Simmons-Smith cyclopropanation reaction.

In 2009 he began independent research at Imperial College London as a Ramsay Memorial Research Fellow (2009-2011), working in the laboratories of Professor Alan Armstrong. From 2011 to 2015 Dr Bull held an EPSRC Career Acceleration Fellowship on "Novel strategies to access chiral heterocycles as potential lead compounds in drug discovery". In January 2016 Dr Bull started a Royal Society University Research Fellowship.



Dubois M, Croft R, Ding Y, et al., 2021, Investigating 3,3-Diaryloxetanes as Potential Bioisosteres Through Matched Molecular Pair Analysis, Rsc Medicinal Chemistry, ISSN:2632-8682

Andresini M, Tota A, Degennaro L, et al., 2021, Synthesis and Transformations of NH‐Sulfoximines, Chemistry – a European Journal, ISSN:0947-6539

Rojas J, Bull J, 2021, Oxetanes and Oxetenes—Monocyclic, Comprehensive Heterocyclic Chemistry

Craven GB, Briggs EL, Zammit CM, et al., 2021, Synthesis and Configurational Assignment of Vinyl Sulfoximines and Sulfonimidamides, The Journal of Organic Chemistry, Vol:86, ISSN:0022-3263, Pages:7403-7424

Boddy A, Bull J, 2021, Stereoselective synthesis and applications of spirocyclic oxindoles, Organic Chemistry Frontiers, Vol:8, ISSN:2052-4110, Pages:1026-1084

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