Imperial College London
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Dr James A Bull

Faculty of Natural Sciences, Department of Chemistry

Reader in Synthetic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5811j.bull Website

 
 
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Location

 

501bMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{St:2019:10.1002/adsc.201900532,
author = {St, John-Campbell S and Bull, JA},
doi = {10.1002/adsc.201900532},
journal = {Advanced Synthesis and Catalysis},
pages = {3662--3682},
title = {Base Metal Catalysis in Directed C(sp<sup>3</sup>)−H Functionalisation},
url = {http://dx.doi.org/10.1002/adsc.201900532},
volume = {361},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Directed C(sp3)−H functionalisation has made enormous progress in recent years, but has largely been restricted to catalysis using noble metals, particularly palladium. However, since 2013, there have been prominent advances that exploit the reactivity of abundant first row transition metals for a multitude of new bond formations. The use of base metal catalysis for C−H functionalisation can provide huge advantages in terms of cost and sustainability compared to methods using noble metals. This review covers all examples, to the end 2018, of auxiliary-assisted, base metal-catalysed C(sp3)−H functionalisation reactions. Successful examples are reported for Fe, Co, Ni and Cu catalysis with monodentate or bidentate directing groups for C−N, C−O, C−S and C−C bond forming reactions. This review aims to highlight the current state of this field and potential for expansion and so scope and limitations are highlighted. Notably, examples to date have required sterically activated α-disubstituted substrates, particularly propanamide derivatives with bidentate directing groups, such as 8-aminoquinoline amides. Monodentate quinoline and thioamide directing groups have also been used with Co catalysis for C−N and C−C bond formations. Mechanistic details are provided to outline the nature of the proposed organometallic intermediates and potential reaction pathways. We hope this review will stimulate further developments in this growing and important field. (Figure presented.).
AU  - St,John-Campbell S
AU  - Bull,JA
DO  - 10.1002/adsc.201900532
EP  - 3682
PY  - 2019///
SN  - 1615-4150
SP  - 3662
TI  - Base Metal Catalysis in Directed C(sp<sup>3</sup>)−H Functionalisation
T2  - Advanced Synthesis and Catalysis
UR  - http://dx.doi.org/10.1002/adsc.201900532
UR  - http://hdl.handle.net/10044/1/70684
VL  - 361
ER  -
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