Imperial College London
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Dr James A Bull

Faculty of Natural Sciences, Department of Chemistry

Reader in Synthetic Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 5811j.bull Website

 
 
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Location

 

501bMolecular Sciences Research HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{St:2019:10.1039/c9cc03644j,
author = {St, John-Campbell S and Bull, JA},
doi = {10.1039/c9cc03644j},
journal = {Chem Commun (Camb)},
pages = {9172--9175},
title = {Intramolecular palladium(ii)/(iv) catalysed C(sp3)-H arylation of tertiary aldehydes using a transient imine directing group.},
url = {http://dx.doi.org/10.1039/c9cc03644j},
volume = {55},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Palladium catalysed β-C(sp3)-H activation of tertiary aldehydes using a transient imine directing group enables intramolecular arylation to form substituted indane-aldehydes. A simple amine bearing a methyl ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives. Preliminary mechanistic studies identify a reversible C-H activation, product inhibition and suggest that oxidative addition is the turnover limiting step.
AU  - St,John-Campbell S
AU  - Bull,JA
DO  - 10.1039/c9cc03644j
EP  - 9175
PY  - 2019///
SP  - 9172
TI  - Intramolecular palladium(ii)/(iv) catalysed C(sp3)-H arylation of tertiary aldehydes using a transient imine directing group.
T2  - Chem Commun (Camb)
UR  - http://dx.doi.org/10.1039/c9cc03644j
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31305810
UR  - http://hdl.handle.net/10044/1/71868
VL  - 55
ER  -
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