Imperial College London

DrJayChatterjee

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

j.chatterjee

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ayakannu:2019:10.1159/000500469,
author = {Ayakannu, T and Murugesu, S and Taylor, AH and Sokhal, P and Ratnasekera, L and Wilhelm-Benartzi, CSM and Lyons, D and Chatterjee, J},
doi = {10.1159/000500469},
journal = {Dermatology},
pages = {327--333},
title = {The Impact of Focality and Centricity on Vulvar Intraepithelial Neoplasia on Disease Progression in HIV+ Patients: A 10-Year Retrospective Study.},
url = {http://dx.doi.org/10.1159/000500469},
volume = {235},
year = {2019}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - BACKGROUND: The impact of lesion focality and centricity in relation to patient outcome and disease recurrence of vulvar intraepithelial neoplasia (VIN) is an understudied area of research, especially in immunocompromised women. The prevalence and incidence of VIN have increased steadily since the 1980s because of the co-existence of human papillomavirus (HPV) and human immunodeficiency virus (HIV). In this study, we retrospectively examined the records of VIN patients to determine the effect of lesion focality and centricity with respect to the interval to disease recurrence. MATERIALS AND METHODS: All women diagnosed with VIN and managed between January 2002 and December 2011 were included (n = 90) and followed up until December 2017. Symptoms at the time of presentation, including HIV positivity (n = 75), were collated, including the influences of multifocality and multicentricity on time to disease recurrence. RESULTS: Multicentricity caused a more rapid recurrence of disease than unicentricity (p = 0.006), whereas multifocality increased the risk of recurrence more than unifocality (p < 0.0001). Viral load in the HIV+ patients was not associated with time to disease recurrence, but the reduced number of CD4+ lymphocytes present in HIV+ patients was. Treatment modalities had no effect on disease recurrence. CONCLUSION: Both focality and centricity have effects on interval to recurrence and final patient outcome, with multifocal disease having a poorer prognosis. Centricity and focality should be recorded at the time of diagnosis and act as a warning for disease recurrence. HIV+ VIN patients with multifocal disease and/or known immunosuppression (low CD4+ lymphocyte counts) should be regarded as "high-risk" patients and treated accordingly.
AU - Ayakannu,T
AU - Murugesu,S
AU - Taylor,AH
AU - Sokhal,P
AU - Ratnasekera,L
AU - Wilhelm-Benartzi,CSM
AU - Lyons,D
AU - Chatterjee,J
DO - 10.1159/000500469
EP - 333
PY - 2019///
SP - 327
TI - The Impact of Focality and Centricity on Vulvar Intraepithelial Neoplasia on Disease Progression in HIV+ Patients: A 10-Year Retrospective Study.
T2 - Dermatology
UR - http://dx.doi.org/10.1159/000500469
UR - https://www.ncbi.nlm.nih.gov/pubmed/31256169
VL - 235
ER -