Imperial College London

DrJayChatterjee

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

j.chatterjee

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Publication Type
Year
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100 results found

Orton S, Karkia R, Mustafov D, Gharanei S, Braoudaki M, Filipe A, Panfilov S, Saravi S, Khan N, Kyrou I, Karteris E, Chatterjee J, Randeva HSet al., 2024, In Silico and In Vitro Mapping of Receptor-Type Protein Tyrosine Phosphatase Receptor Type D in Health and Disease: Implications for Asprosin Signalling in Endometrial Cancer and Neuroblastoma, Cancers, Vol: 16

Background: Protein Tyrosine Phosphatase Receptor Type D (PTPRD) is involved in the regulation of cell growth, differentiation, and oncogenic transformation, as well as in brain development. PTPRD also mediates the effects of asprosin, which is a glucogenic hormone/adipokine derived following the cleavage of the C-terminal of fibrillin 1. Since the asprosin circulating levels are elevated in certain cancers, research is now focused on the potential role of this adipokine and its receptors in cancer. As such, in this study, we investigated the expression of PTPRD in endometrial cancer (EC) and the placenta, as well as in glioblastoma (GBM). Methods: An array of in silico tools, in vitro models, tissue microarrays (TMAs), and liquid biopsies were employed to determine the gene and protein expression of PTPRD in healthy tissues/organs and in patients with EC and GBM. Results: PTPRD exhibits high expression in the occipital lobe, parietal lobe, globus pallidus, ventral thalamus, and white matter, whereas in the human placenta, it is primarily localised around the tertiary villi. PTPRD is significantly upregulated at the mRNA and protein levels in patients with EC and GBM compared to healthy controls. In patients with EC, PTPRD is significantly downregulated with obesity, whilst it is also expressed in the peripheral leukocytes. The EC TMAs revealed abundant PTPRD expression in both low- and high-grade tumours. Asprosin treatment upregulated the expression of PTPRD only in syncytialised placental cells. Conclusions: Our data indicate that PTPRD may have potential as a biomarker for malignancies such as EC and GBM, further implicating asprosin as a potential metabolic regulator in these cancers. Future studies are needed to explore the potential molecular mechanisms/signalling pathways that link PTPRD and asprosin in cancer.

Journal article

Ray I, Möller-Levet CS, Michael A, Butler-Manuel S, Chatterjee J, Tailor A, Ellis PE, Meira LBet al., 2024, Circulating Adipocytokines and Insulin Like-Growth Factors and Their Modulation in Obesity-Associated Endometrial Cancer, Cancers, Vol: 16

The rising global incidence of uterine cancer is linked to the escalating prevalence of obesity. Obesity results in alterations in adipocytokines and IGFs, driving cancer progression via inflammation, increased cell proliferation, and apoptosis inhibition, although the precise mechanisms are still unclear. This study examined a set of six markers, namely, adiponectin, leptin, IL6, TNFα, IGF1, and IGF2 and compared them between fifty age-matched endometrial cancer patients (study group) and non-cancer patients with benign gynaecological conditions (control group). We also assessed the relationship of these markers with obesity and explored the correlation between these markers and various tumour characteristics. In the cancer population, these markers were also assessed 24 h and 6 months post-surgery. Remarkably, low adiponectin levels were associated with a 35.8% increase in endometrial cancer risk. Interestingly, compared to control subjects where IGF levels decreased after menopause, post-menopausal women in the study group showed elevated IGF1 and IGF2 levels, suggesting a potential influence of endometrial cancer on the IGF system, particularly after menopause. Lastly, it is noteworthy that a discernible inverse relationship trend was observed in the levels of adipocytokines and IGFs 6 months post-surgery. This indicates that treatment for endometrial cancer may have a differential impact on adipocytokines and IGFs, potentially holding clinical significance that merits further investigation.

Journal article

Montgomery A, Boo M, Chatterjee J, 2023, Fertility-Sparing Management of Early Stage Endometrial Cancer: A Narrative Review of the Literature, CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY, Vol: 50, ISSN: 0390-6663

Journal article

Mahendran T, Ashworth M, Phillips ME, Chatterjee Jet al., 2023, Nutritional Management of Gynaecological Cancer Patients, Nutritional Management of the Surgical Patient, Pages: 178-186, ISBN: 9781119809098

Malnutrition continues to be a significant challenge in gynaecological cancer, mainly in ovarian cancer management, despite significant improvement in treatment algorithms and understanding of metabolic pathways and the role of inflammation. A multidisciplinary approach with individualised targeted nutrition is vital to improve the quality of care in these cancer patients.

Book chapter

Uwins C, Read J, Tailor A, Crawshaw J, Chatterjee J, Ellis P, Skene S, Michael A, Butler-Manuel Set al., 2022, MIRRORS STUDY: A PROSPECTIVE COHORT STUDY ASSESSING THE FEASIBILITY OF ROBOTIC INTERVAL CYTOREDUCTIVE SURGERY FOR ADVANCED-STAGE OVARIAN CANCER, Publisher: BMJ PUBLISHING GROUP, Pages: A24-A24, ISSN: 1048-891X

Conference paper

Uwins C, Hablase R, Assalaarachchi H, Tailor A, Stewart A, Chatterjee J, Ellis P, Skene SS, Michael A, Butler-Manuel Set al., 2022, Enhanced Recovery after Uterine Corpus Cancer Surgery: A 10 Year Retrospective Cohort Study of Robotic Surgery in an NHS Cancer Centre, CANCERS, Vol: 14

Journal article

Karkia R, Wali S, Payne A, Karteris E, Chatterjee Jet al., 2022, Diagnostic Accuracy of Liquid Biomarkers for the Non-Invasive Diagnosis of Endometrial Cancer: A Systematic Review and Meta-Analysis, CANCERS, Vol: 14

Journal article

Karkia R, Tailor A, Ellis P, Madhuri T, Scala A, Read J, Perry M, Patil K, Blackburn A, Butler-Manuel S, Chatterjee Jet al., 2022, Minimally invasive pelvic exenteration for gynaecological malignancy: A single-centre case series and review of the literature, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, Vol: 274, Pages: 56-61, ISSN: 0301-2115

Journal article

Zahra A, Hall M, Chatterjee J, Sisu C, Karteris Eet al., 2022, In silico study to predict the structural and functional consequences of SNPs on biomarkers of Ovarian Cancer (OC) and BPA exposure-associated OC, International Journal of Molecular Sciences, Vol: 23, ISSN: 1422-0067

BACKGROUND: Recently, we have shown that seven genes, namely GBP5, IRS2, KRT4, LINCOO707, MRPL55, RRS1 and SLC4A11, have prognostic power for the overall survival in ovarian cancer (OC). METHODS: We present an analysis on the association of these genes with any phenotypes and mutations indicative of involvement in female cancers and predict the structural and functional consequences of those SNPS using in silico tools. RESULTS: These seven genes present with 976 SNPs/mutations that are associated with human cancers, out of which 284 related to female cancers. We have then analysed the mutation impact on amino acid polarity, charge and water affinity, leading to the identification of 30 mutations in gynaecological cancers where amino acid (aa) changes lead to opposite polarity, charges and water affinity. Out of these 30 mutations identified, only a missense mutation (i.e., R831C/R804C in uterine corpus endometrial carcinomas, UCEC) was suggestive of structural damage on the SLC4A11 protein. CONCLUSIONS: We demonstrate that the R831C/R804C mutation is deleterious and the predicted ΔΔG values suggest that the mutation reduces the stability of the protein. Future in vitro studies should provide further insight into the role of this transporter protein in UCEC.

Journal article

Uwins C, Patel H, Bhandoria GP, Butler-Manuel S, Tailor A, Ellis P, Chatterjee Jet al., 2021, Laparoscopic and Robotic Surgery for Endometrial and Cervical Cancer, CLINICAL ONCOLOGY, Vol: 33, Pages: E372-E382, ISSN: 0936-6555

Journal article

Hutt S, Mihaies D, Karteris E, Michael A, Payne AM, Chatterjee Jet al., 2021, Statistical Meta-Analysis of Risk Factors for Endometrial Cancer and Development of a Risk Prediction Model Using an Artificial Neural Network Algorithm, CANCERS, Vol: 13

Journal article

Tan A, Mahendran T, Butler-Manuel S, Tailor A, Ellis P, Chatterjee J, Madhuri Tet al., 2021, Robotics in gynaecological oncology: enhanced recovery outcomes following 1500 cases in Guildford, Publisher: WILEY, Pages: 73-73, ISSN: 1470-0328

Conference paper

Uwins C, Tailor A, Chatterjee J, 2021, 254 Robotic corpus cancer surgery: ten year mortality data from the UK epicentre in guildford (vol 30, pf A31, 2020), INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 31, Pages: E3-E3, ISSN: 1048-891X

Journal article

Uwins C, Read J, Tailor A, Chatterjee J, Ellis P, Skene S, Michael A, Butler-Manuel Set al., 2021, MIRRORS STUDY: A PROSPECTIVE COHORT STUDY ASSESSING THE FEASIBILITY OF ROBOTIC INTERVAL DEBULKING SURGERY FOR ADVANCED-STAGE OVARIAN CANCER, Publisher: BMJ PUBLISHING GROUP, Pages: A295-A296, ISSN: 1048-891X

Conference paper

Uwins C, Michael A, Tailor A, Chatterjee J, Ellis P, Madhuri T, Skene S, Butler-Manuel Set al., 2020, MIRRORS TRIAL: MINIMALLY INVASIVE ROBOTIC SURGERY, ROLE IN OPTIMAL DEBULKING OVARIAN CANCER, RECOVERY & SURVIVAL, Publisher: BMJ PUBLISHING GROUP, Pages: A111-A112, ISSN: 1048-891X

Conference paper

Uwins C, Tailor A, Chatterjee J, Ellis P, Madhuri T, Michael A, Butler-Manuel Set al., 2020, ROBOTIC CORPUS CANCER SURGERY: TEN YEAR MORTALITY DATA FROM THE UK EPICENTRE IN GUILDFORD, Publisher: BMJ PUBLISHING GROUP, Pages: A31-A32, ISSN: 1048-891X

Conference paper

Bossy M, Nyman M, Madhuri TK, Tailor A, Chatterjee J, Butler-Manuel S, Ellis P, Feldheiser A, Creagh-Brown Bet al., 2020, The need for post-operative vasopressor infusions after major gynae-oncologic surgery within an ERAS (Enhanced Recovery After Surgery) pathway, PERIOPERATIVE MEDICINE, Vol: 9

Journal article

Uwins C, Bhandoria GP, Shylasree TS, Butler-Manuel S, Ellis P, Chatterjee J, Tailor A, Stewart A, Michael Aet al., 2020, COVID-19 and gynecological cancer: a review of the published guidelines, INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, Vol: 30, Pages: 1424-1433, ISSN: 1048-891X

Journal article

Patel H, Madhuri K, Rockell T, Montaser R, Ellis P, Chatterjee J, Butler-Manuel S, Tailor Aet al., 2020, Robotic radical hysterectomy for stage 1B1 cervical cancer: A case series of survival outcomes from a leading UK cancer centre, INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY, Vol: 16, ISSN: 1478-5951

Journal article

Nepogodiev D, 2020, Elective surgery cancellations due to theCOVID-19 pandemic: global predictive modelling to inform surgical recovery plans, British Journal of Surgery, Vol: 107, Pages: 1440-1449, ISSN: 0007-1323

BackgroundThe COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.MethodsA global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption. A Bayesian β-regression model was used to estimate 12-week cancellation rates for 190 countries. Elective surgical case-mix data, stratified by specialty and indication (surgery for cancer versus benign disease), were determined. This case mix was applied to country-level surgical volumes. The 12-week cancellation rates were then applied to these figures to calculate the total number of cancelled operations.ResultsThe best estimate was that 28 404 603 operations would be cancelled or postponed during the peak 12 weeks of disruption due to COVID-19 (2 367 050 operations per week). Most would be operations for benign disease (90·2 per cent, 25 638 922 of 28 404 603). The overall 12-week cancellation rate would be 72·3 per cent. Globally, 81·7 per cent of operations for benign conditions (25 638 922 of 31 378 062), 37·7 per cent of cancer operations (2 324 070 of 6 162 311) and 25·4 per cent of elective caesarean sections (441 611 of 1 735 483) would be cancelled or postponed. If countries increased their normal surgical volume by 20 per cent after the pandemic, it would take a median of 45 weeks to clear the backlog of operations resulting from COVID-19 disruption.ConclusionA very large number of operations will be cancelled or postponed owing to disruption caused by COVID-19. Governments should mitigate against this major burden on patients by developing recovery plans and implementing strategies to restore surgical activity safely.

Journal article

Otter SJ, Chatterjee J, Stewart AJ, Michael Aet al., 2019, The Role of Biomarkers for the Prediction of Response to Checkpoint Immunotherapy and the Rationale for the Use of Checkpoint Immunotherapy in Cervical Cancer, CLINICAL ONCOLOGY, Vol: 31, Pages: 834-843, ISSN: 0936-6555

Journal article

Katopodis P, Chudasama D, Wander G, Sales L, Kumar J, Pandhal M, Anikin V, Chatterjee J, Hall M, Karteris Eet al., 2019, Kinase Inhibitors and Ovarian Cancer, CANCERS, Vol: 11

Journal article

Kumar J, Murugaiah V, Sotiriadis G, Kaur A, Jeyaneethi J, Stumiolo L, Alhamlan FS, Chatterjee J, Hall M, Kishore U, Karteris Eet al., 2019, Surfactant Protein D as a Potential Biomarker and Therapeutic Target in Ovarian Cancer, FRONTIERS IN ONCOLOGY, Vol: 9, ISSN: 2234-943X

Journal article

Kumar J, Chudasama D, Roberts C, Kubista M, Sjoback R, Chatterjee J, Anikin V, Karteris E, Hall Met al., 2019, Detection of Abundant Non-Haematopoietic Circulating Cancer-Related Cells in Patients with Advanced Epithelial Ovarian Cancer, CELLS, Vol: 8

Journal article

Patel H, Madhuri K, Tailor A, Ellis P, Chatterjee J, Butler-Manuel Set al., 2019, Survival outcomes for robotically managed stage 1b1 cancer of the cervix, Publisher: WILEY, Pages: 85-85, ISSN: 1470-0328

Conference paper

Patel R, Vedanarayanan V, Chatterjee J, Parker Cet al., 2019, Association of Migraine and Asthma in Pediatric Patients: A National Perspective on Gender and Racial Disparities, 61st Annual Scientific Meeting of the American-Headache-Society, Publisher: WILEY, Pages: 73-74, ISSN: 0017-8748

Conference paper

Hutt S, Tailor A, Ellis P, Michael A, Butler-Manuel S, Chatterjee Jet al., 2019, The role of biomarkers in endometrial cancer and hyperplasia: a literature review, ACTA ONCOLOGICA, Vol: 58, Pages: 342-352, ISSN: 0284-186X

Journal article

Otter S, Whitaker S, Chatterjee J, Stewart Aet al., 2019, The Human Papillomavirus as a Common Pathogen in Oropharyngeal, Anal and Cervical Cancers, CLINICAL ONCOLOGY, Vol: 31, Pages: 81-90, ISSN: 0936-6555

Journal article

International Surgical Outcomes Study ISOS group, 2019, Prospective observational cohort study on grading the severity of postoperative complications in global surgery research., Br J Surg, Vol: 106, Pages: e73-e80

BACKGROUND: The Clavien-Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien-Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs). METHODS: This was a secondary analysis of the International Surgical Outcomes Study (ISOS), a prospective observational cohort study of elective surgery in adults. Data collection occurred over a 7-day period. Severity of complications was graded using Clavien-Dindo and the simpler ISOS grading (mild, moderate or severe, based on guided investigator judgement). Severity grading was compared using the intraclass correlation coefficient (ICC). Data are presented as frequencies and ICC values (with 95 per cent c.i.). The analysis was stratified by income status of the country, comparing HICs with LMICs. RESULTS: A total of 44 814 patients were recruited from 474 hospitals in 27 countries (19 HICs and 8 LMICs). Some 7508 patients (16·8 per cent) experienced at least one postoperative complication, equivalent to 11 664 complications in total. Using the ISOS classification, 5504 of 11 664 complications (47·2 per cent) were graded as mild, 4244 (36·4 per cent) as moderate and 1916 (16·4 per cent) as severe. Using Clavien-Dindo, 6781 of 11 664 complications (58·1 per cent) were graded as I or II, 1740 (14·9 per cent) as III, 2408 (20·6 per cent) as IV and 735 (6·3 per cent) as V. Agreement between classification systems was poor overall (ICC 0·41, 95 per cent c.i. 0·20 to 0·55), and in LMICs (ICC 0·23, 0·05 to 0·38) and HICs (ICC 0·46, 0·25 to 0·59). CONCLUSION: Caution is recommended when using a treatment approach to grade complications in global sur

Journal article

Rogers-Broadway K-R, Kumar J, Sisu C, Wander G, Mazey E, Jeyaneethi J, Pados G, Tsolakidis D, Klonos E, Grunt T, Hall M, Chatterjee J, Karteris Eet al., 2019, Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, Vol: 43, Pages: 47-56, ISSN: 1107-3756

Journal article

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