Imperial College London
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DrJamesChoi

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 1777j.choi Website

 
 
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Location

 

RSM 4.06Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Koruk:2018:10.1121/1.5034175,
author = {Koruk, H and Choi, JJ},
doi = {10.1121/1.5034175},
journal = {Journal of the Acoustical Society of America},
pages = {2535--2540},
title = {Displacement of a bubble by acoustic radiation force into a fluid-tissue interface.},
url = {http://dx.doi.org/10.1121/1.5034175},
volume = {143},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Microbubbles in an ultrasound beam experience a primary Bjerknes force, which pushes the microbubbles against a fluid-tissue interface and deforms the tissue. This interaction has been used to measure tissue elasticity and is a common interaction in many therapeutic and diagnostic applications, but the mechanisms of deformation, and how the deformation dynamic depends on the bubble and ultrasound parameters, remain unknown. In this study, a mathematical model is proposed for the displacement of a bubble onto a fluid-tissue interface and the tissue deformation in response to the primary Bjerknes force. First, a model was derived for static loading and the model's prediction of bubble-mediated tissue displacement and stresses in tissue were explored. Second, the model was updated for dynamic loading. The results showed that the bubble is both displaced by the applied force and changes its shape. The bubble displacement changes nonlinearly with the applied force. The stress values in tissue are quite high for a distance within one radius of the bubble from the bubble surface. The model proposed here is permissible in human tissue and can be used for biomedical ultrasound applications, including material characterization.
AU  - Koruk,H
AU  - Choi,JJ
DO  - 10.1121/1.5034175
EP  - 2540
PY  - 2018///
SN  - 0001-4966
SP  - 2535
TI  - Displacement of a bubble by acoustic radiation force into a fluid-tissue interface.
T2  - Journal of the Acoustical Society of America
UR  - http://dx.doi.org/10.1121/1.5034175
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29716276
UR  - http://hdl.handle.net/10044/1/59977
VL  - 143
ER  -
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