Imperial College London
Portrait Picture

DrJamesChoi

Faculty of Engineering, Department of Bioengineering

Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 1777j.choi Website

 
 
//

Location

 

RSM 4.06Royal School of MinesSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Davies:2021:10.1109/tuffc.2020.3026165,
author = {Davies, HJ and Morse, SV and Copping, MJ and Sujarittam, K and Bourgin, VD and Tang, M-X and Choi, JJ},
doi = {10.1109/tuffc.2020.3026165},
journal = {IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control},
pages = {178--190},
title = {Imaging with therapeutic acoustic wavelets–short pulses enable acoustic localization when time of arrival is combined with delay and sum},
url = {http://dx.doi.org/10.1109/tuffc.2020.3026165},
volume = {68},
year = {2021}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - —Passive acoustic mapping (PAM) is an algorithm that reconstructs the location of acoustic sourcesusing an array of receivers. This technique can monitor therapeutic ultrasound procedures to confirm the spatial distribution and amount of microbubble activity induced. CurrentPAM algorithms have an excellentlateral resolution but havea poor axial resolution, making it difficult to distinguishacoustic sources within the ultrasound beams. With recentstudies demonstrating that short-length and low-pressurepulses—acoustic wavelets—have the therapeutic function,we hypothesizedthat the axial resolution could be improvedwith a quasi-pulse-echo approach and that the resolutionimprovement would depend on the wavelet’s pulse length.This article describes an algorithm that resolves acousticsources axially using time of flight and laterally using delayand-sum beamforming, which we named axial temporalposition PAM (ATP-PAM). The algorithm accommodates arapid short pulse (RaSP) sequence that can safely deliverdrugs across the blood–brain barrier. We developed ouralgorithm with simulations (k-wave) and in vitro experiments for one-, two-, and five-cycle pulses, comparingour resolution against that of two current PAM algorithms.We then tested ATP-PAM in vivo and evaluated whether thereconstructed acoustic sources mapped to drug delivery
AU  - Davies,HJ
AU  - Morse,SV
AU  - Copping,MJ
AU  - Sujarittam,K
AU  - Bourgin,VD
AU  - Tang,M-X
AU  - Choi,JJ
DO  - 10.1109/tuffc.2020.3026165
EP  - 190
PY  - 2021///
SN  - 0885-3010
SP  - 178
TI  - Imaging with therapeutic acoustic wavelets–short pulses enable acoustic localization when time of arrival is combined with delay and sum
T2  - IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
UR  - http://dx.doi.org/10.1109/tuffc.2020.3026165
UR  - https://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=9205900
UR  - http://hdl.handle.net/10044/1/85687
VL  - 68
ER  -
Download