Imperial College London

ProfessorJorgeFerrer

Faculty of MedicineDepartment of Medicine

Chair in Medicine and Genetics
 
 
 
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Contact

 

+44 (0)20 7594 0968j.ferrer

 
 
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Location

 

530ICTEM buildingHammersmith Campus

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Summary

 

Summary

Professor Ferrer is chair in Genetics and Medicine, Head of the Section of Epigenomics and Disease, and Theme Leader for Genetics and Genomics in the NIHR Imperial Biomedical Research Centre. He is also a Wellcome Trust Senior Investigator. He received his medical degree and trained in Endocrinology in the University of Barcelona School of Medicine. He subsequently trained in genetics and transcriptional regulation in Washington University and Harvard University before returning to Barcelona in 1997. There he established a research team within Institut d’Investigacions Biomediques August Pi i Sunyer and CIBERDEM, a Spanish diabetes research network. He recently moved to Imperial College London where he has established a laboratory based at Imperial Centre for Translational and Experimental Medicine.

Professor Ferrer is interested in understanding genome regulation of pancreatic beta cells and its implications for human diabetes. His team has combined genetic model systems and advanced genomics to address key questions in human beta cell biology, regeneration, and disease.

Related links

Section website
Lab website
Genomics Facility website

Selected Publications

Journal Articles

Cebola I, Rodriguez-Segui SA, Cho CH-H, et al., 2015, TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors, Nature Cell Biology, Vol:17, ISSN:1465-7392, Pages:615-U183

Pasquali L, Gaulton KJ, Rodriguez-Segui SA, et al., 2014, Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants, Nature Genetics, Vol:46, ISSN:1546-1718, Pages:136-+

Weedon MN, Cebola I, Patch A-M, et al., 2014, Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis, Nature Genetics, Vol:46, ISSN:1061-4036, Pages:61-+

van Arensbergen J, Garcia-Hurtado J, Angel Maestro M, et al., 2013, Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult beta cells, Genes & Development, Vol:27, ISSN:0890-9369, Pages:52-63

Moran I, Akerman I, van de Bunt M, et al., 2012, Human beta Cell Transcriptome Analysis Uncovers IncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes, Cell Metabolism, Vol:16, ISSN:1550-4131, Pages:435-448

van Arensbergen J, García-Hurtado J, Moran I, et al., 2010, Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program., Genome Res, Vol:20, Pages:722-732

Gaulton KJ, Nammo T, Pasquali L, et al., 2010, A map of open chromatin in human pancreatic islets., Nat Genet, Vol:42, Pages:255-259

Solar M, Cardalda C, Houbracken I, et al., 2009, Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth., Dev Cell, Vol:17, Pages:849-860

More Publications