Imperial College London

DR JAMES M. FLANAGAN

Faculty of MedicineDepartment of Surgery & Cancer

Non-Clinical Senior Lecturer
 
 
 
//

Contact

 

+44 (0)20 7594 2127j.flanagan

 
 
//

Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

//

Summary

 

Summary

Lab Projects

Dr James Flanagan, completed his PhD in 2002 at the Queensland Institute of Medical Research in Brisbane, Australia, and has pursued postdoctoral work in Cancer Genetics, Epigenetics and Cancer Epigenetics. He was awarded a Breast Cancer Campaign Scientific Fellowship (Imperial, 2009-2014) and is now a Senior Lecturer (2014-present) in the Division of Cancer, Dept. of Surgery and Cancer, Faculty of Medicine at Imperial College London. He was awarded the British Association of Cancer Research Translational Researcher Award in 2011 and is the principal investigator for the OCA funded programme "Risk and Prevention" based in the Ovarian Cancer Action Research Centre.

Current research is aimed at investigating epigenetic alterations as a mechanism for carcinogenesis, including projects to define tumour subgroups, identification of biomarkers for cancer risk or prognosis in breast and ovarian cancer and investigating the hypothesis that epigenetic variation may be a driver of cancer risk whether by inherent constitutional variation or as a mediator of other cancer risk factors.


Google Scholarhttps://upload.wikimedia.org/wikipedia/commons/a/aa/ResearchGate_Logo.png

ORCID logo

Selected Publications

Journal Articles

Flanagan JM, Wilson A, Koo C, et al., 2016, Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients, Clinical Cancer Research, Vol:23, ISSN:1557-3265, Pages:2213-2222

van veldhoven K, Polidoro S, Baglietto L, et al., 2015, Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis, Clinical Epigenetics, Vol:7, ISSN:1868-7083

Shenker NS, Polidoro S, van Veldhoven K, et al., 2013, Epigenome-wide association study in the European Prospective Investigation into Cancer and Nutrition (EPIC-Turin) identifies novel genetic loci associated with smoking, Human Molecular Genetics, Vol:22, ISSN:0964-6906, Pages:843-851

Brennan K, Garcia-Closas M, Orr N, et al., 2012, Intragenic ATM Methylation in Peripheral Blood DNA as a Biomarker of Breast Cancer Risk, Cancer Research, Vol:72, ISSN:0008-5472, Pages:2304-2313

Flanagan JM, Cocciardi S, Waddell N, et al., 2010, DNA Methylome of Familial Breast Cancer Identifies Distinct Profiles Defined by Mutation Status, American Journal of Human Genetics, Vol:86, ISSN:0002-9297, Pages:420-433

More Publications