Summary
Brief Biosketch
Professor Jon Friedland is Campus Director of the Hammersmith Campus and Head of Infectious Diseases and Immunity at Imperial College London. He is an Honorary Consultant in Infectious Diseases at Imperial College Healthcare NHS Trust. Jon Friedland graduated in medicine from Cambridge University and Kings College, London University. After medical training at London Postgraduate Hospitals and the John Radcliffe Hospital in Oxford, he completed a PhD as part of a MRC Training Fellowship. He was appointed Senior Lecturer/Hon Consultant at the Royal Postgraduate Medical School in 1993 becoming Reader at Imperial College in 2000 and Departmental Chair in 2004.
His major research interest is in innate immune response and particularly the role of matrix metalloproteinase’s in the immunopathology of tuberculosis and the development of novel therapeutic approaches. He has a longstanding research interest in migrant health as well as interests in new TB diagnostics. During the course of his research, he has published over 190 peer reviewed papers, invited editorials and reviews as well as 3 books. Our Research team won the Medical Futures Innovations Award for best overall innovation (from 1200). In 2005, Jon Friedland was awarded the Royal College of Physicians Weber-Parkes Prize Medal for research in tuberculosis. He was elected Fellow of the Academy of Medical Sciences in 2008 and a Fellow of the Royal College of Physicians of Ireland in 2010. In 2017, he was awarded an inaugural Fellowship of the European Society of Clinical Microbiology and Infectious Diseases.
Selected Publications
Journal Articles
Ong C, Pabisiak P, Dos Santos Brilha S, et al., 2017, Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis, Journal of Neuroinflammation, Vol:14, ISSN:1742-2094
Hargreaves S, Nellums L, Friedland JS, 2016, Time to rethink approaches to migrant health screening, Lancet, Vol:388, ISSN:1474-547X, Pages:2456-2457
Friedland JS, Ong CWN, Elkington PT, et al., 2015, Neutrophil-derived MMP-8 drives AMPK- dependant matrix destruction in human pulmonary tuberculosis, PLOS Pathogens, Vol:11, ISSN:1553-7366
Singh S, Saraiva L, Elkington PTG, et al., 2014, Regulation of matrix metalloproteinase-1,-3, and-9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin- sensitive PI3K/p70<SUP>S6K</SUP> cascade, The FASEB Journal, Vol:28, ISSN:0892-6638, Pages:85-93
Elkington P, Shiomi T, Breen R, et al., 2011, MMP-1 drives immunopathology in human tuberculosis and transgenic mice, Journal of Clinical Investigation, Vol:121, ISSN:0021-9738, Pages:1827-1833