Imperial College London
Alternate

ProfessorJonFriedland

Faculty of Medicine, Department of Infectious Disease

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 8521j.friedland Website

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

250 results found

Kutschenreuter J, Loader MC, Kirwan DE, Gilman RH, Friedland JS, Chong DLWet al., 2022, LEUCINE-RICH 2 GLYCOPROTEIN-1 UPREGULATION IN PLASMA OF PATIENTS WITH ACTIVE TUBERCULOSIS, Winter Meeting of the British-Thoracic-Society (BTS), Publisher: BMJ PUBLISHING GROUP, Pages: A52-A53, ISSN: 0040-6376

Conference paper

Baggaley RF, Zenner D, Bird P, Hargreaves S, Griffiths C, Noori T, Friedland JS, Nellums LB, Pareek Met al., 2022, Prevention and treatment of infectious diseases in migrants in Europe in the era of universal health coverage, LANCET PUBLIC HEALTH, Vol: 7, Pages: E876-E884, ISSN: 2468-2667

Journal article

Margineanu I, Rustage K, Noori T, Zenner D, Greenaway C, Pareek M, Akkerman O, Hayward S, Friedland JS, Goletti D, Stienstra Y, Hargreaves Set al., 2022, Country-specific approaches to latent tuberculosis screening targeting migrants in EU/EEA* countries: A survey of national experts, September 2019 to February 2020, EUROSURVEILLANCE, Vol: 27, ISSN: 1025-496X

Journal article

Migliori GB, Wu SJ, Matteelli A, Zenner D, Goletti D, Ahmedov S, Al-Abri S, Allen DM, Balcells ME, Garcia-Basteiro AL, Cambau E, Chaisson RE, Chee CBE, Dalcolmo MP, Denholm JT, Erkens C, Esposito S, Farnia P, Friedland JS, Graham S, Hamada Y, Harries AD, Kay AW, Kritski A, Manga S, Marais BJ, Menzies D, Ng D, Petrone L, Rendon A, Silva DR, Schaaf HS, Skrahina A, Sotgiu G, Thwaites G, Tiberi S, Tukvadze N, Zellweger J-P, Ambrosio LD, Centis R, Ong CWMet al., 2022, Clinical standards for the diagnosis, treatment and prevention of TB infection, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 26, Pages: 190-+, ISSN: 1027-3719

Journal article

Poh XY, Loh FK, Friedland JS, Ong CWMet al., 2022, Neutrophil-Mediated Immunopathology and Matrix Metalloproteinases in Central Nervous System - Tuberculosis, FRONTIERS IN IMMUNOLOGY, Vol: 12, ISSN: 1664-3224

Journal article

Hayward SE, Deal A, Rustage K, Nellums LB, Sweetland AC, Boccia D, Hargreaves S, Friedland JSet al., 2022, The relationship between mental health and risk of active tuberculosis: a systematic review, BMJ OPEN, Vol: 12, ISSN: 2044-6055

Journal article

Rustage K, Lobe J, Hayward SE, Kristensen KL, Margineanu I, Stienstra Y, Goletti D, Zenner D, Noori T, Pareek M, Greenaway C, Friedland JS, Nellums LB, Hargreaves Set al., 2021, Initiation and completion of treatment for latent tuberculosis infection in migrants globally: a systematic review and meta-analysis, LANCET INFECTIOUS DISEASES, Vol: 21, Pages: 1701-1712, ISSN: 1473-3099

Journal article

Deal A, Halliday R, Crawshaw AF, Hayward SE, Burnard A, Rustage K, Carter J, Mehrotra A, Knights F, Campos-Matos I, Majeed A, Friedland JS, Edelstein M, Mounier-Jack S, Hargreaves S, European Society of Clinical Microbiology and Infectious Diseases Study Group for Infections in Travellers and Migrants ESGITMet al., 2021, Migration and outbreaks of vaccine-preventable disease in Europe: a systematic review, Lancet Infectious Diseases, Vol: 21, ISSN: 1473-3099

Migrant populations are one of several underimmunised groups in the EU or European Economic Area (EU/EEA), yet little is known about their involvement in outbreaks of vaccine-preventable diseases. This information is vital to develop targeted strategies to improve the health of diverse migrant communities. We did a systematic review (PROSPERO CRD42019157473; Jan 1, 2000, to May 22, 2020) adhering to PRISMA guidelines, to identify studies on vaccine-preventable disease outbreaks (measles, mumps, rubella, diphtheria, pertussis, polio, hepatitis A, varicella, Neisseria meningitidis, and Haemophilus influenzae) involving migrants residing in the EU/EEA and Switzerland. We identified 45 studies, reporting on 47 distinct vaccine-preventable disease outbreaks across 13 countries. Most reported outbreaks involving migrants were of measles (n=24; 6496 cases), followed by varicella (n=11; 505 cases), hepatitis A (n=7; 1356 cases), rubella (n=3; 487 cases), and mumps (n=2; 293 cases). 19 (40%) outbreaks, predominantly varicella and measles, were reported in temporary refugee camps or shelters. Of 11 varicella outbreaks, nine (82%) were associated with adult migrants. Half of measles outbreaks (n=11) were associated with migrants from eastern European countries. In conclusion, migrants are involved in vaccine-preventable disease outbreaks in Europe, with adult and child refugees residing in shelters or temporary camps at particular risk, alongside specific nationality groups. Vulnerability varies by disease, setting, and demographics, highlighting the importance of tailoring catch-up vaccination interventions to specific groups in order to meet regional and global vaccination targets as recommended by the new Immunisation Agenda 2030 framework for action. A better understanding of vaccine access and intent in migrant groups and a greater focus on co-designing interventions is urgently needed, with direct implications for COVID-19 vaccine delivery.

Journal article

Rustage K, Crawshaw A, Majeed-Hajaj S, Deal A, Nellums L, Ciftci Y, Fuller SS, Goldsmith L, Friedland JS, Hargreaves Set al., 2021, Participatory approaches in the development of health interventions for migrants: a systematic review, BMJ OPEN, Vol: 11, ISSN: 2044-6055

Journal article

Hayward S, Deal A, Rustage K, Nellums LB, Sweetland AC, Boccia D, Hargreaves S, Friedland JSet al., 2021, A systematic review of the association between mental health and tuberculosis disease risk, Publisher: OXFORD UNIV PRESS, ISSN: 1101-1262

Conference paper

Hayward SE, Rustage K, Nellums LB, van der Werf MJ, Noori T, Boccia D, Friedland JS, Hargreaves Set al., 2021, Extrapulmonary tuberculosis among migrants in Europe, 1995 to 2017, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 27, ISSN: 1198-743X

Journal article

Miow QH, Vallejo AF, Wang Y, Hong JM, Bai C, Teo FSW, Wang ADY, Loh HR, Tan TZ, Ding Y, She HW, Gan SH, Paton N, Lum J, Tay A, Chee CBE, Tambyah PA, Polak ME, Wang YT, Singhal A, Elkington PT, Friedland JS, Ong CWMet al., 2021, Doxycycline host-directed therapy in human pulmonary tuberculosis, JOURNAL OF CLINICAL INVESTIGATION, Vol: 131, ISSN: 0021-9738

Journal article

Loader MCI, Vasquez S, Verastegui M, Coronel J, Taquiri C, Gilman RH, Friedland JSet al., 2021, Elevated MMP-10 and MMP-13 in patients co-infected with pulmonary tuberculosis and soil-transmitted helminth infections, Publisher: WILEY, Pages: 260-260, ISSN: 0014-2980

Conference paper

Kutschenreuter J, Friedland JS, Chong DLW, 2021, Neutrophil-dependent secretion of the biomarker LRG1 in tuberculosis, 6th European Congress of Immunology (ECI), Publisher: WILEY, Pages: 86-86, ISSN: 0014-2980

Conference paper

Kirwan DE, Chong DLW, Friedland JS, 2021, Platelet Activation and the Immune Response to Tuberculosis, FRONTIERS IN IMMUNOLOGY, Vol: 12, ISSN: 1664-3224

Journal article

Nellums LB, Powis J, Jones L, Miller A, Rustage K, Russell N, Friedland JS, Hargreaves Set al., 2021, "It's a life you're playing with": A qualitative study on experiences of NHS maternity services among undocumented migrant women in England, SOCIAL SCIENCE & MEDICINE, Vol: 270, ISSN: 0277-9536

Journal article

Carter J, Friedland JS, Kirwan DE, Nathavitharana RRet al., 2020, Translating scientific discoveries during pandemics: ensuring equity for people affected by COVID-19 and tuberculosis, ERJ OPEN RESEARCH, Vol: 6

Journal article

Ong CWM, Migliori GB, Raviglione M, MacGregor-Skinner G, Sotgiu G, Alffenaar J-W, Tiberi S, Adlhoch C, Alonzi T, Archuleta S, Brusin S, Cambau E, Capobianchi MR, Castilletti C, Castilletti C, Centis R, Cirillo DM, Ambrosio LD, Delogu G, Esposito SMR, Figueroa J, Friedland JS, Ho BCH, Ippolito G, Jankovic M, Kim HY, Klintz SR, Kodmon C, Lalle E, Leo YS, Leung C-C, Martson A-G, Melazzini MG, Fard SN, Penttinen P, Petrone L, Petruccioli E, Pontali E, Saderi L, Santin M, Spanevello A, van Crevel R, van der Werf WJ, Visca D, Viveiros M, Zellweger J-P, Zumla A, Goletti Det al., 2020, Epidemic and pandemic viral infections: impact on tuberculosis and the lung, EUROPEAN RESPIRATORY JOURNAL, Vol: 56, ISSN: 0903-1936

Journal article

Hayward SE, van der Werf MJ, Noori T, Nellums LB, Boccia D, Friedland JS, Hargreaves Set al., 2020, Extrapulmonary tuberculosis among migrants in the EU/EFTA: Implications for policy and practice, Publisher: OXFORD UNIV PRESS, ISSN: 1101-1262

Conference paper

Kristensen KL, Ravn P, Petersen JH, Hargreaves S, Nellums LB, Friedland JS, Andersen PH, Norredam M, Lillebaek Tet al., 2020, Long-term risk of tuberculosis among migrants according to migrant status: a cohort study, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, Vol: 49, Pages: 776-785, ISSN: 0300-5771

Journal article

Walker NF, Opondo C, Meintjes GA, Jhilmeet N, Friedland J, Elkington PT, Wilkinson RJ, Wilkinson KAet al., 2020, Invariant Natural Killer T cell dynamics in HIV-associated tuberculosis, Clinical Infectious Diseases, Vol: 70, Pages: 1865-1874, ISSN: 1058-4838

RationaleTuberculosis (TB) is the leading cause of mortality and morbidity in people living with HIV infection. HIV-infected patients with TB disease are at risk of the paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) when they commence anti-retroviral therapy. However, the pathophysiology is incompletely understood and specific therapy is lacking.ObjectivesWe investigated the hypothesis that invariant Natural Killer T (iNKT) cells contribute to innate immune dysfunction associated with TB-IRIS.MethodsIn a cross-sectional study of 101 HIV-infected and -uninfected South African patients with active TB and controls, iNKT cells were enumerated using α-galactosylceramide-loaded CD1d tetramers and subsequently functionally characterised by flow cytometry. In a second study of 49 HIV-1-infected TB patients commencing anti-retroviral therapy, iNKT cells in TB-IRIS patients with non-IRIS controls were compared longitudinally.Measurements and main resultsCirculating iNKT cells were reduced in HIV-1 infection, most significantly the CD4+ subset, which was inversely associated with HIV-1 viral load. iNKT cells in HIV-associated TB had increased surface CD107a expression, indicating cytotoxic degranulation. Relatively increased iNKT cell frequency in HIV-infected patients with active TB was associated with development of TB-IRIS following anti-retroviral therapy initiation. iNKT cells in TB-IRIS were CD4+CD8- subset deplete and degranulated around the time of TB-IRIS onset.ConclusionsReduced iNKT cell CD4+ subsets as a result of HIV-1 infection may skew iNKT cell functionality towards cytotoxicity. Increased CD4- cytotoxic iNKT cells may contribute to immunopathology in TB-IRIS.

Journal article

Tanoglu A, Erdem H, Friedland JS, Almajid FM, Batirel A, Kulzhanova S, Konkayeva M, Smagulova Z, Pehlivanoglu F, de Saram S, Gulsun S, Amer F, Balkan II, Tekin R, Cascio A, Dauby N, Sirmatel F, Tasbakan M, Erdem A, Wegdan AA, Aydin O, Cesur S, Deniz S, Senbayrak S, Denk A, Duzenli T, Simeon S, Oncul A, Ozseker B, Yakar T, Ormeci Net al., 2020, Clinicopathological profile of gastrointestinal tuberculosis: a multinational ID-IRI study, EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, Vol: 39, Pages: 493-500, ISSN: 0934-9723

Journal article

Hargreaves S, Rustage K, Nellums LB, Friedland JS, Zimmerman Cet al., 2019, Occupational health outcomes among international migrant workers Reply, LANCET GLOBAL HEALTH, Vol: 7, Pages: E1616-E1616, ISSN: 2214-109X

Journal article

Hargreaves S, Himmels J, Nellums LB, McGuire E, Friedland JSet al., 2019, Vaccination status of migrant populations in EU/EEA countries and implications for VPD control, Publisher: OXFORD UNIV PRESS, ISSN: 1101-1262

Conference paper

Kristensen KL, Lillebaek T, Petersen JH, Hargreaves S, Nellums LB, Friedland JS, Andersen PH, Ravn P, Norredam Met al., 2019, Tuberculosis incidence among migrants according to migrant status: a cohort study, Denmark, 1993 to 2015, EUROSURVEILLANCE, Vol: 24, Pages: 14-24, ISSN: 1025-496X

Journal article

Kristensen KL, Lillebaek T, Petersen JH, Hargreaves S, Nellums L, Friedland JS, Andersen PH, Ravn P, Noerredam Met al., 2019, Long-term incidence of tuberculosis among migrants according to migrant status: a cohort study, International Congress of the European-Respiratory-Society (ERS), Publisher: EUROPEAN RESPIRATORY SOC JOURNALS LTD, ISSN: 0903-1936

Conference paper

Hargreaves S, Rustage K, Nellums LB, McAlpine A, Pocock N, Devakumar D, Aldridge RW, Abubakar I, Kristensen KL, Himmels JW, Friedland JS, Zimmerman Cet al., 2019, Occupational health outcomes among international migrant workers: a systematic review and meta-analysis, LANCET GLOBAL HEALTH, Vol: 7, Pages: E872-E882, ISSN: 2214-109X

Journal article

Osborne W, Chavda A, Katritsis G, Friedland JSet al., 2019, Lesson of the month 1: A rare adverse reaction between flucloxacillin and paracetamol, CLINICAL MEDICINE, Vol: 19, Pages: 127-128, ISSN: 1470-2118

Journal article

Sloth LB, Nielsen RT, Ostergaard C, Nellums LB, Hargreaves S, Friedland JS, Norredam Met al., 2019, Antibiotic resistance patterns of <i>Escherichia coli</i> in migrants vs non-migrants: a study of 14 561 urine samples, JOURNAL OF TRAVEL MEDICINE, Vol: 26, ISSN: 1195-1982

Journal article

Aldridge RW, Nellums LB, Bartlett S, Barr AL, Patel P, Burns R, Hargreaves S, Jaime Miranda J, Tollman S, Friedland JS, Abubakar Iet al., 2018, Global patterns of mortality in international migrants: a systematic review and meta-analysis, LANCET, Vol: 392, Pages: 2553-2566, ISSN: 0140-6736

Journal article

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