Imperial College London

ProfessorJonathanFriedland

Faculty of MedicineDepartment of Medicine

Chair in Infectious Diseases and Immunity
 
 
 
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Contact

 

+44 (0)20 3313 8521j.friedland Website

 
 
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Assistant

 

Miss Amy Cock +44 (0)20 3313 1943

 
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Location

 

8N21ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

197 results found

Nellums LB, Goldberg J, Hargreaves S, Friedland Jet al., Patterns of emergency department use among migrants in Europe and implications for infectious disease screening: a systematic review and meta-analysis, 26th European Congress of Clinical Microbiology and Infectious Diseases

CONFERENCE PAPER

Noori M, Nellums L, Hargreaves S, Nelson-Piercy C, Friedland Jet al., Pregnancy outcomes in non-UK born women in a tertiary level maternity unit: a pilot study, British Maternal and Fetal Medicine Society, Publisher: Wiley: 12 months, ISSN: 1471-0528

CONFERENCE PAPER

Saunders MS, Tovar MA, Zevallos KZ, Montoya RM, Valencia TV, Gilman R, Friedland JS, Evans CAet al., Can micronutrient supplementation prevent TB in vulnerable household contacts? A randomised controlled trial, 47th Union World Conference on Lung Health

CONFERENCE PAPER

Brace PT, Tezera LB, Bielecka MK, Mellows T, Garay D, Tian S, Rand L, Green J, Jogai S, Steele AJ, Millar TM, Sanchez-Elsner T, Friedland JS, Proud CG, Elkington PTet al., 2017, Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology, PLOS PATHOGENS, Vol: 13, ISSN: 1553-7366

JOURNAL ARTICLE

Brilha S, Sathyamoorthy T, Stuttaford LH, Walker NF, Wilkinson RJ, Singh S, Moores RC, Elkington PT, Friedland JSet al., 2017, Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in Tuberculosis, AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol: 56, Pages: 223-232, ISSN: 1044-1549

JOURNAL ARTICLE

Brilha S, Wysoczanski R, Whittington AM, Friedland JS, Porter JCet al., 2017, Monocyte Adhesion, Migration, and Extracellular Matrix Breakdown Are Regulated by Integrin alpha V beta 3 in Mycobacterium tuberculosis Infection, JOURNAL OF IMMUNOLOGY, Vol: 199, Pages: 982-991, ISSN: 0022-1767

JOURNAL ARTICLE

Hargreaves S, Duarte R, Friedland JS, 2017, The role of pre-migration medical screening in high TB burden countries, INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, Vol: 21, Pages: 718-719, ISSN: 1027-3719

JOURNAL ARTICLE

Hargreaves S, Lonnroth K, Nellums LB, Olaru ID, Nathavitharana RR, Norredam M, Friedland JSet al., 2017, Multidrug-resistant tuberculosis and migration to Europe, CLINICAL MICROBIOLOGY AND INFECTION, Vol: 23, Pages: 141-146, ISSN: 1198-743X

JOURNAL ARTICLE

Matos ED, Gilman RH, Moore DAJ, Hasan Rizvi SM, Ticona E, Kirwan DE, Cabrera JL, Ugarte-Gil C, Friedland; JS, Cerrillo G, Cok J, Evans CAet al., 2017, Histological Examination in Obtaining a Diagnosis in Patients with Lymphadenopathy in Lima, Peru, The American Journal of Tropical Medicine and Hygiene, ISSN: 0002-9637

JOURNAL ARTICLE

Moores RC, Brilha S, Schutgens F, Elkington PT, Friedland JSet al., 2017, Epigenetic Regulation of Matrix Metalloproteinase-1 and-3 Expression in Mycobacterium tuberculosis Infection, FRONTIERS IN IMMUNOLOGY, Vol: 8, ISSN: 1664-3224

JOURNAL ARTICLE

Ong CWM, Pabisiak PJ, Brilha S, Singh P, Roncaroli F, Elkington PT, Friedland JSet al., 2017, Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis, JOURNAL OF NEUROINFLAMMATION, Vol: 14, ISSN: 1742-2094

JOURNAL ARTICLE

Proano A, Bravard MA, Lopez JW, Lee GO, Bui D, Datta S, Comina G, Zimic M, Coronel J, Caviedes L, Cabrera JL, Salas A, Ticona E, Vu NM, Kirwan DE, Loader M-CI, Friedland JS, Moore DAJ, Evans CA, Tracey BH, Gilman RHet al., 2017, Dynamics of Cough Frequency in Adults Undergoing Treatment for Pulmonary Tuberculosis, CLINICAL INFECTIOUS DISEASES, Vol: 64, Pages: 1174-1181, ISSN: 1058-4838

JOURNAL ARTICLE

Saunders MJ, Wingfield T, Tovar MA, Baldwin MR, Datta S, Zevallos K, Montoya R, Valencia TR, Friedland JS, Moulton LH, Gilman RH, Evans CAet al., 2017, A score to predict and stratify risk of tuberculosis in adult contacts of tuberculosis index cases: a prospective derivation and external validation cohort study., Lancet Infect Dis

BACKGROUND: Contacts of tuberculosis index cases are at increased risk of developing tuberculosis. Screening, preventive therapy, and surveillance for tuberculosis are underused interventions in contacts, particularly adults. We developed a score to predict risk of tuberculosis in adult contacts of tuberculosis index cases. METHODS: In 2002-06, we recruited contacts aged 15 years or older of index cases with pulmonary tuberculosis who lived in desert shanty towns in Ventanilla, Peru. We followed up contacts for tuberculosis until February, 2016. We used a Cox proportional hazards model to identify index case, contact, and household risk factors for tuberculosis from which to derive a score and classify contacts as low, medium, or high risk. We validated the score in an urban community recruited in Callao, Peru, in 2014-15. FINDINGS: In the derivation cohort, we identified 2017 contacts of 715 index cases, and median follow-up was 10·7 years (IQR 9·5-11·8). 178 (9%) of 2017 contacts developed tuberculosis during 19 147 person-years of follow-up (incidence 0·93 per 100 person-years, 95% CI 0·80-1·08). Risk factors for tuberculosis were body-mass index, previous tuberculosis, age, sustained exposure to the index case, the index case being in a male patient, lower community household socioeconomic position, indoor air pollution, previous tuberculosis among household members, and living in a household with a low number of windows per room. The 10-year risks of tuberculosis in the low-risk, medium-risk, and high-risk groups were, respectively, 2·8% (95% CI 1·7-4·4), 6·2% (4·8-8·1), and 20·6% (17·3-24·4). The 535 (27%) contacts classified as high risk accounted for 60% of the tuberculosis identified during follow-up. The score predicted tuberculosis independently of tuberculin skin test and index-case drug sensitivity results. In the external validation cohort, 65 (3%)

JOURNAL ARTICLE

Walker NF, Wilkinson KA, Meintjes G, Tezera LB, Goliath R, Peyper JM, Tadokera R, Opondo C, Coussens AK, Wilkinson RJ, Friedland JS, Elkington PTet al., 2017, Matrix Degradation in Human Immunodeficiency Virus Type 1-Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study, CLINICAL INFECTIOUS DISEASES, Vol: 65, Pages: 121-132, ISSN: 1058-4838

JOURNAL ARTICLE

Belton M, Brilha S, Manavaki R, Mauri F, Nijran K, Hong YT, Patel NH, Dembek M, Tezera L, Green J, Moores R, Aigbirhio F, Al-Nahhas A, Fryer TD, Elkington PT, Friedland JSet al., 2016, Hypoxia and tissue destruction in pulmonary TB, THORAX, Vol: 71, Pages: 1145-1153, ISSN: 0040-6376

JOURNAL ARTICLE

Dudley MZ, Sheen P, Gilman RH, Ticona E, Friedland JS, Kirwan DE, Caviedes L, Rodriguez R, Cabrera LZ, Coronel J, Grandjean L, Moore DAJ, Evans CA, Huaroto L, Chavez-Perez V, Zimic Met al., 2016, Detecting Mutations in the Mycobacterium tuberculosis Pyrazinamidase Gene pncA to Improve Infection Control and Decrease Drug Resistance Rates in Human Immunodeficiency Virus Coinfection, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 95, Pages: 1239-1246

JOURNAL ARTICLE

Hargreaves S, Nellums L, Friedland JS, 2016, Time to rethink approaches to migrant health screening, LANCET, Vol: 388, Pages: 2456-2457, ISSN: 0140-6736

JOURNAL ARTICLE

Hargreaves S, Nellums L, Friedland JS, Goldberg J, Murwill P, Jones Let al., 2016, Extending migrant charging into emergency services, BMJ-BRITISH MEDICAL JOURNAL, Vol: 352, ISSN: 1756-1833

JOURNAL ARTICLE

Kubler A, Larsson C, Luna B, Andrade BB, Amaral EP, Urbanowski M, Orandle M, Bock K, Ammerman NC, Cheung LS, Winglee K, Halushka M, Park JK, Sher A, Friedland JS, Elkington PT, Bishai WRet al., 2016, Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis, JOURNAL OF INFECTIOUS DISEASES, Vol: 213, Pages: 618-627, ISSN: 0022-1899

JOURNAL ARTICLE

Martin LJ, Roper MH, Grandjean L, Gilman RH, Coronel J, Caviedes L, Friedland JS, Moore DAJet al., 2016, Rationing tests for drug-resistant tuberculosis - who are we prepared to miss?, BMC MEDICINE, Vol: 14, ISSN: 1741-7015

JOURNAL ARTICLE

Proano A, Bravard MA, Tracey BH, Lopez JW, Comina G, Zimic M, Coronel J, Lee GO, Caviedes L, Luis Cabrera J, Salas A, Ticona E, Kirwan DE, Friedland JS, Evans CA, Moore DA, Gilman RHet al., 2016, Protocol for studying cough frequency in people with pulmonary tuberculosis, BMJ OPEN, Vol: 6, ISSN: 2044-6055

JOURNAL ARTICLE

Al Shammari B, Shiomi T, Tezera L, Bielecka MK, Workman V, Sathyamoorthy T, Mauri F, Jayasinghe SN, Robertson BD, D'Armiento J, Friedland JS, Elkington PTet al., 2015, The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis, JOURNAL OF INFECTIOUS DISEASES, Vol: 212, Pages: 463-473, ISSN: 0022-1899

JOURNAL ARTICLE

Elkington PT, Friedland JS, 2015, Permutations of time and place in tuberculosis, LANCET INFECTIOUS DISEASES, Vol: 15, Pages: 1357-1360, ISSN: 1473-3099

JOURNAL ARTICLE

Kirwan D, Ugarte-Gil C, Gilman RH, Caviedes L, Hasan Rizvi SM, Ticona E, Chavez G, Cabrera JL, Matos ED, Evans CA, Moore DAJ, Friedland JSet al., 2015, Microscopic Observation Drug Susceptibility Assay for Rapid Diagnosis of Lymph Node Tuberculosis and Detection of Drug Resistance, Journal of Clinical Microbiology, Vol: 54, Pages: 185-189, ISSN: 1098-660X

In the study, 132 patients with lymphadenopathy were investigated. 52 (39.4%) were diagnosed with TB. MODS provided rapid (13 days), accurate diagnosis (sensitivity 65.4%), and reliable DST. Despite lower sensitivity than other methods, faster results and simultaneous DST are advantageous in resource-poor settings, supporting incorporation of MODS into diagnostic algorithms for extrapulmonary TB.

JOURNAL ARTICLE

Kuebler A, Luna B, Larsson C, Ammerman NC, Andrade BB, Orandle M, Bock KW, Xu Z, Bagci U, Molura DJ, Marshall J, Burns J, Winglee K, Ahidjo BA, Cheung LS, Klunk M, Jain SK, Kumar NP, Babu S, Sher A, Friedland JS, Elkington PTG, Bishai WRet al., 2015, Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferation, JOURNAL OF PATHOLOGY, Vol: 235, Pages: 431-444, ISSN: 0022-3417

JOURNAL ARTICLE

Nathavitharana RR, Friedland JS, 2015, A tale of two global emergencies: tuberculosis control efforts can learn from the Ebola outbreak, EUROPEAN RESPIRATORY JOURNAL, Vol: 46, Pages: 293-296, ISSN: 0903-1936

JOURNAL ARTICLE

Ong CWM, Elkington PT, Brilha S, Ugarte-Gil C, Tome-Esteban MT, Tezera LB, Pabisiak PJ, Moores RC, Sathyamoorthy T, Patel V, Gilman RH, Porter JC, Friedland JSet al., 2015, Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis, PLOS PATHOGENS, Vol: 11, ISSN: 1553-7366

JOURNAL ARTICLE

Sathyamoorthy T, Sandhu G, Tezera LB, Thomas R, Singhania A, Woelk CH, Dimitrov BD, Agranoff D, Evans CAW, Friedland JS, Elkington PTet al., 2015, Gender-Dependent Differences in Plasma Matrix Metalloproteinase-8 Elevated in Pulmonary Tuberculosis, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Sathyamoorthy T, Tezera LB, Walker NF, Brilha S, Saraiva L, Mauri FA, Wilkinson RJ, Friedland JS, Elkington PTet al., 2015, Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis, JOURNAL OF IMMUNOLOGY, Vol: 195, Pages: 882-891, ISSN: 0022-1767

JOURNAL ARTICLE

Ugarte-Gil C, Elkington PT, Gotuzzo E, Friedland JS, Moore DAJet al., 2015, Induced Sputum Is Safe and Well-Tolerated for TB Diagnosis in a Resource-Poor Primary Healthcare Setting, AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, Vol: 92, Pages: 633-635, ISSN: 0002-9637

JOURNAL ARTICLE

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