Imperial College London
Alternate

ProfessorJonFriedland

Faculty of Medicine, Department of Infectious Disease

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3313 8521j.friedland Website

 
 
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Assistant

 

Ms Teyanna Gaeta +44 (0)20 3313 1943

 
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Location

 

8N21ACommonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Proaño:2016:10.1136/bmjopen-2015-010365,
author = {Proaño, A and Bravard, MA and Tracey, BH and López, JW and Comina, G and Zimic, M and Coronel, J and Lee, GON and Caviedes, L and Cabrera, JL and Salas, A and Ticona, E and Kirwan, DE and Friedland, JS and Evans, CA and Moore, DA and Gilman, RH and Peru, TWGI},
doi = {10.1136/bmjopen-2015-010365},
journal = {BMJ open},
pages = {e010365--e010365},
title = {Protocol for studying cough frequency in people with pulmonary tuberculosis},
url = {http://dx.doi.org/10.1136/bmjopen-2015-010365},
volume = {6},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - INTRODUCTION: Cough is a key symptom of tuberculosis (TB) as well as the main cause of transmission. However, a recent literature review found that cough frequency (number of coughs per hour) in patients with TB has only been studied once, in 1969. The main aim of this study is to describe cough frequency patterns before and after the start of TB treatment and to determine baseline factors that affect cough frequency in these patients. Secondarily, we will evaluate the correlation between cough frequency and TB microbiological resolution. METHODS: This study will select participants with culture confirmed TB from 2 tertiary hospitals in Lima, Peru. We estimated that a sample size of 107 patients was sufficient to detect clinically significant changes in cough frequency. Participants will initially be evaluated through questionnaires, radiology, microscopic observation drug susceptibility broth TB-culture, auramine smear microscopy and cough recordings. This cohort will be followed for the initial 60 days of anti-TB treatment, and throughout the study several microbiological samples as well as 24 h recordings will be collected. We will describe the variability of cough episodes and determine its association with baseline laboratory parameters of pulmonary TB. In addition, we will analyse the reduction of cough frequency in predicting TB cure, adjusted for potential confounders. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the ethics committees at each participating hospital in Lima, Peru, Asociación Benéfica PRISMA in Lima, Peru, the Universidad Peruana Cayetano Heredia in Lima, Peru and Johns Hopkins University in Baltimore, USA. We aim to publish and disseminate our findings in peer-reviewed journals. We also expect to create and maintain an online repository for TB cough sounds as well as the statistical analysis employed.
AU  - Proaño,A
AU  - Bravard,MA
AU  - Tracey,BH
AU  - López,JW
AU  - Comina,G
AU  - Zimic,M
AU  - Coronel,J
AU  - Lee,GON
AU  - Caviedes,L
AU  - Cabrera,JL
AU  - Salas,A
AU  - Ticona,E
AU  - Kirwan,DE
AU  - Friedland,JS
AU  - Evans,CA
AU  - Moore,DA
AU  - Gilman,RH
AU  - Peru,TWGI
DO  - 10.1136/bmjopen-2015-010365
EP  - 010365
PY  - 2016///
SN  - 2044-6055
SP  - 010365
TI  - Protocol for studying cough frequency in people with pulmonary tuberculosis
T2  - BMJ open
UR  - http://dx.doi.org/10.1136/bmjopen-2015-010365
UR  - http://hdl.handle.net/10044/1/32847
VL  - 6
ER  -
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