Imperial College London

Mr James W. Hindley

Faculty of Natural SciencesDepartment of Chemistry

Research Associate
 
 
 
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Contact

 

+44 (0)20 7589 5111 ext 55816j.hindley14 Website

 
 
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Location

 

207Molecular Sciences Research HubWhite City Campus

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Summary

 

Summary

Mr James Hindley is an EPSRC Doctoral Prize Fellow primarily under the supervision of Professor Oscar Ces (Chemistry) and Professor Charlotte Bevan (Surgery and Cancer). His research focuses on the development of soft matter materials at the nano- and micro-scale that can respond to specific stimuli such as temperature, light and chemical/mechanical change for applications including drug delivery, biocatalysis and synthetic biology.

By using chemical and biological motifs to imbue function in self-assembled lipid structures, a toolkit of lipid systems can be created. These can then be combined across length scales to engineer structures capable of functions that mimic cellular behaviour. Building artificial cells from the bottom-up enables a better understanding of cell biology, as well as creating systems that can interface with biology, enabling the control of biological systems.

James is based in the EPSRC-funded Institute of Chemical Biology - Centre for Doctoral Training, and is associated with the Membrane Biophysics Platform and "CAPITALS" EPSRC Programme Grant. 

RESEARCH HIGHLIGHTS

Designing new signalling pathways from the bottom-up in artificial cells - PNAS, Press Release

Engineering light-responsive artificial cells that function as enzyme microreactors - Nature CommunicationsPress ReleaseNature Research Blog - Science Imitates Art

Engineering patterned thermoresponsive vesicles for content release - Chemical Science

Publications

Journals

Hindley JW, Zheleva DG, Elani Y, et al., 2019, Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells, Proceedings of the National Academy of Sciences, Vol:116, ISSN:0027-8424, Pages:16711-16716

Karamdad K, Hindley J, Friddin MS, et al., 2018, Engineering thermoresponsive phase separated vesicles formed via emulsion phase transfer as a content-release platform, Chemical Science, Vol:9, ISSN:2041-6520, Pages:4851-4858

Hindley JW, Elani Y, McGilvery CM, et al., 2018, Light-triggered enzymatic reactions in nested vesicle reactors, Nature Communications, Vol:9, ISSN:2041-1723

Salzmann CG, Slater B, Radaelli PG, et al., 2016, Detailed crystallographic analysis of the ice VI to ice XV hydrogen ordering phase transition, Journal of Chemical Physics, Vol:145, ISSN:0021-9606

Messager L, Burns JR, Kim J, et al., 2016, Biomimetic hybrid nanocontainers with selective permeability, Angewandte Chemie International Edition, Vol:55, ISSN:1521-3757, Pages:11106-11109

More Publications