Mr James Hindley is an EPSRC Doctoral Prize Fellow primarily under the supervision of Professor Oscar Ces (Chemistry) and Professor Charlotte Bevan (Surgery and Cancer). His research focuses on the development of soft matter materials at the nano- and micro-scale that can respond to specific stimuli such as temperature, light and chemical/mechanical change for applications including drug delivery, biocatalysis and synthetic biology.
By using chemical and biological motifs to imbue function in self-assembled lipid structures, a toolkit of lipid systems can be created. These can then be combined across length scales to engineer structures capable of functions that mimic cellular behaviour. Building artificial cells from the bottom-up enables a better understanding of cell biology, as well as creating systems that can interface with biology, enabling the control of biological systems.
James is based in the EPSRC-funded Institute of Chemical Biology - Centre for Doctoral Training, and is associated with the Membrane Biophysics Platform and "CAPITALS" EPSRC Programme Grant.
Engineering patterned thermoresponsive vesicles for content release - Chemical Science
et al., 2019, Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells, Proceedings of the National Academy of Sciences, Vol:116, ISSN:0027-8424, Pages:16711-16716
et al., 2018, Engineering thermoresponsive phase separated vesicles formed via emulsion phase transfer as a content-release platform, Chemical Science, Vol:9, ISSN:2041-6520, Pages:4851-4858
et al., 2018, Light-triggered enzymatic reactions in nested vesicle reactors, Nature Communications, Vol:9, ISSN:2041-1723
et al., 2016, Detailed crystallographic analysis of the ice VI to ice XV hydrogen ordering phase transition, Journal of Chemical Physics, Vol:145, ISSN:0021-9606
et al., 2016, Biomimetic hybrid nanocontainers with selective permeability, Angewandte Chemie International Edition, Vol:55, ISSN:1521-3757, Pages:11106-11109