113 results found
Poynter L, Galea D, Veselkov K, et al., 2019, Network Mapping of Molecular Biomarkers Influencing Radiation Response in Rectal Cancer., Clin Colorectal Cancer
Preoperative radiotherapy (RT) plays an important role in the management of locally advanced rectal cancer (RC). Tumor regression after RT shows marked variability, and robust molecular methods are needed to help predict likely response. The aim of this study was to review the current published literature and use Gene Ontology (GO) analysis to define key molecular biomarkers governing radiation response in RC. A systematic review of electronic bibliographic databases (Medline, Embase) was performed for original articles published between 2000 and 2015. Biomarkers were then classified according to biological function and incorporated into a hierarchical GO tree. Both significant and nonsignificant results were included in the analysis. Significance was binarized on the basis of univariate and multivariate statistics. Significance scores were calculated for each biological domain (or node), and a direct acyclic graph was generated for intuitive mapping of biological pathways and markers involved in RC radiation response. Seventy-two individual biomarkers across 74 studies were identified. On highest-order classification, molecular biomarkers falling within the domains of response to stress, cellular metabolism, and pathways inhibiting apoptosis were found to be the most influential in predicting radiosensitivity. Homogenizing biomarker data from original articles using controlled GO terminology demonstrated that cellular mechanisms of response to RT in RC-in particular the metabolic response to RT-may hold promise in developing radiotherapeutic biomarkers to help predict, and in the future modulate, radiation response.
Kinross JM, 2018, Precision gaming for health: Computer games as digital medicine., Methods, Vol: 151, Pages: 28-33
Health based games have significant potential as therapeutic interventions due to the inherent mechanisms associated with social and individual game play and their capacity for sensor integration, data capture analysis and patient feedback. Moreover, they are low cost and they can be deployed at the point of care across an evolving digital ecosystem. However, a robust evidence base to support their wider adoption as a clinical intervention for chronic diseases is lacking and significant methodological barriers exist for health games developers creating efficacious 'digital medicines'. Game design is complex and it must utilise validated game mechanics balanced with a creative and engaging game design. The aim of this review is therefore to outline the fundamental steps of game development for health professionals and to critically appraise the methodology for assessing health games as medical interventions. This requires (1) The adoption of clearly defined global language for health games development based on a targeted function as therapeutic agents. (2) The development of multidisciplinary teams with a broad portfolio of development and clinical skill sets. (3) The creation of health game engines specifically built to facilitate clinical game development. (4) Robust trial design and assessment of translational impact: If games are to be prescribed, their efficacy and toxicity must be based on a rigorous assessment of their use within a real world clinical environment. Trials for precision health games have specific challenges around blinding, learning curves, bias and confounding that are particularly problematic. We propose the adoption of the IDEAL-GAMES framework for game development that systematically assess and validates games through open registries. In conclusion we propose a new framework for assessing the robustness and clinical efficacy of games for health as clinical interventions in the clinical environment.
Jitsumura M, Cunningham AL, Hitchings MD, et al., 2018, Protocol for faecal microbiota transplantation in ulcerative colitis (FMTUC): a randomised feasibility study, BMJ OPEN, Vol: 8, ISSN: 2044-6055
Pouncey AL, Scott AJ, Alexander JL, et al., 2018, Gut microbiota, chemotherapy and the host: the influence of the gut microbiota on cancer treatment, ECANCERMEDICALSCIENCE, Vol: 12, ISSN: 1754-6605
Alexander JL, Scott AJ, Pouncey AL, et al., 2018, Colorectal carcinogenesis: an archetype of gut microbiota-host interaction, ECANCERMEDICALSCIENCE, Vol: 12, ISSN: 1754-6605
Alexander JL, Scott A, Poynter LR, et al., 2018, Sa1840 - The Colorectal Cancer Mucosal Microbiome is Defined by Disease Stage and the Tumour Metabonome, Pages: S-415-S-415, ISSN: 0016-5085
Clift AK, Kornasiewicz O, Drymousis P, et al., 2018, Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management, ENDOCRINE CONNECTIONS, Vol: 7, Pages: 268-277, ISSN: 2049-3614
Pawa N, Clift AK, Osmani H, et al., 2018, Surgical Management of Patients with Neuroendocrine Neoplasms of the Appendix: Appendectomy or More?, NEUROENDOCRINOLOGY, Vol: 106, Pages: 242-251, ISSN: 0028-3835
Scott AJ, Merrifield CA, Alexander JL, et al., 2017, Highlights from the Inaugural International Cancer Microbiome Consortium Meeting (ICMC), 5-6 September 2017, London, UK, ECANCERMEDICALSCIENCE, Vol: 11, ISSN: 1754-6605
Galea D, Inglese P, Cammack L, et al., 2017, Translational utility of a hierarchical classification strategy in biomolecular data analytics, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322
Kinross J, 2017, Race-specific differences in mucosal sulfidogenic bacteria modify colon cancer risk, GUT, Vol: 66, Pages: 1884-1885, ISSN: 0017-5749
Kinross J, Mirnezami R, Alexander J, et al., 2017, A prospective analysis of mucosal microbiome-metabonome interactions in colorectal cancer using a combined MAS 1HNMR and metataxonomic strategy, SCIENTIFIC REPORTS, Vol: 7, ISSN: 2045-2322
Alexander JL, Wilson ID, Teare J, et al., 2017, Gut microbiota modulation of chemotherapy efficacy and toxicity, NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, Vol: 14, Pages: 356-365, ISSN: 1759-5045
Martin G, Kinross J, Hankin C, 2017, Effective cybersecurity is fundamental to patient safety, BMJ-BRITISH MEDICAL JOURNAL, Vol: 357, ISSN: 1756-1833
Inglese P, McKenzie JS, Mroz A, et al., 2017, Deep learning and 3D-DESI imaging reveal the hidden metabolic heterogeneity of cancer, CHEMICAL SCIENCE, Vol: 8, Pages: 3500-3511, ISSN: 2041-6520
Wolfer AM, Scott AJ, Rueb C, et al., 2017, Longitudinal analysis of serum oxylipin profile as a novel descriptor of the inflammatory response to surgery, JOURNAL OF TRANSLATIONAL MEDICINE, Vol: 15, ISSN: 1479-5876
Mason SE, Kinross JM, Hendricks J, et al., 2017, Postoperative hypothermia and surgical site infection following peritoneal insufflation with warm, humidified carbon dioxide during laparoscopic colorectal surgery: a cohort study with cost-effectiveness analysis, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 31, Pages: 1923-1929, ISSN: 0930-2794
Alexander JL, Perdones-Montero A, Cameron S, et al., 2017, A PROSPECTIVE MULTI-NATIONAL STUDY OF THE COLORECTAL CANCER MUCOSAL MICROBIOME REVEALS SPECIFIC TAXONOMIC CHANGES INDICATIVE OF DISEASE STAGE AND PROGNOSIS, Digestive Disease Week (DDW), Publisher: W B SAUNDERS CO-ELSEVIER INC, Pages: S1010-S1011, ISSN: 0016-5085
Alexander J, Gildea L, Balog J, et al., 2017, A novel methodology for in vivo endoscopic phenotyping of colorectal cancer based on real-time analysis of the mucosal lipidome: a prospective observational study of the iKnife, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, Vol: 31, Pages: 1361-1370, ISSN: 0930-2794
Diederen K, Li JV, Kinross J, et al., Exclusive enteral nutrition mediates gut metabolic changes in children with Crohn’s disease, Digestive Disease Week
, 2016, UEG Week 2016 Oral Presentations, Pages: A1-A156, ISSN: 2050-6406
Kinross JM, Muirhead L, Alexander J, et al., 2016, iKnife: Rapid evaporative ionization mass spectrometry (REIMS) enables real-time chemical analysis of the mucosal lipidome for diagnostic and prognostic use in colorectal cancer, AACR 107th Annual Meeting on Bioinformatics and Systems Biology, Publisher: AMER ASSOC CANCER RESEARCH, ISSN: 0008-5472
Alexander JL, Scott A, Mroz A, et al., 2016, 91 Mass Spectrometry Imaging (MSI) of Microbiome-Metabolome Interactions in Colorectal Cancer, Pages: S23-S23, ISSN: 0016-5085
Kinross JM, marchesi J, 2016, The Ageing Superorganism, Metabolic Phenotyping in Personalized and Public Healthcare, Editors: Nicholson, darzi, Holmes
The aging population represents one of the greatest health challenges of modern times. For the first time in history, those over the age of 60 years will outnumber children under the age of 5 years. If the quality of life and the health of this growing population are to be improved, a deeper understanding of the aging process is required. This chapter analyzes aging from a superorganism perspective; it analyzes the contribution of the vast numbers of bacteria that inhabit the gut and the impact they have on human health; it provides a systematic overview of how the “-omics” technologies are revolutionizing our understanding of the biology of aging; it assesses our current understanding of how health may be maintained in advanced aging; and it looks to the future applications of the “-omics” technologies in this area.
Kinross J, Marchesi JR, 2016, The aging superorganism, Metabolic Phenotyping in Personalized and Public Healthcare, Pages: 265-290, ISBN: 9780128003442
© 2016 Elsevier Inc. All rights reserved. The aging population represents one of the greatest health challenges of modern times. For the first time in history, those over the age of 60 years will outnumber children under the age of 5 years. If the quality of life and the health of this growing population are to be improved, a deeper understanding of the aging process is required. This chapter analyzes aging from a superorganism perspective; it analyzes the contribution of the vast numbers of bacteria that inhabit the gut and the impact they have on human health; it provides a systematic overview of how the "-omics" technologies are revolutionizing our understanding of the biology of aging; it assesses our current understanding of how health may be maintained in advanced aging; and it looks to the future applications of the "-omics" technologies in this area.
Kinross J, Muirhead L, Takats Z, 2016, Precision surgery and surgical spectroscopy, Metabolic Phenotyping in Personalized and Public Healthcare, Pages: 75-109, ISBN: 9780128003442
© 2016 Elsevier Inc. All rights reserved. Surgical practice is largely based on 20th century principles, and little, if any, biological data is provided to the clinician either preoperatively or intraoperatively to assist in decision making. Therefore novel technologies are urgently required to deliver the vision of personalized health care in surgery. Metabolic phenotyping has distinct advantages over other "-omics" based technologies in surgery, as the analysis of thousands of metabolites is possible in near real time, and it is able to provide critical data on tissue phenotypes and on the functional biochemistry of surgical pathology during surgery. The inference is that surgeons, pathologists, oncologists, and physicians will be able to augment current clinical strategies with chemical analysis at the patient bedside or in the operating theater. This chapter explores emerging technologies in this field and provides practical applications of their use in several areas of surgery and perioperative care. Particular attention is paid to oncology and the application of ambient mass spectrometry technologies in this field.
Tekkis P, Tan E, Kontovounisios C, et al., 2015, Hand-sewn coloanal anastomosis for low rectal cancer: technique and long-term outcome, Colorectal Disease, Vol: 17, Pages: 1062-1070, ISSN: 1463-1318
AimThis study compared the operative outcome and long-term survival of three types of hand-sewn coloanal anastomosis (CAA) for low rectal cancer.MethodPatients presenting with low rectal cancer at a single centre between 2006 and 2014 were classified into three types of hand-sewn CAA: type 1 (supra-anal tumours undergoing transabdominal division of the rectum with transanal mucosectomy); type 2 (juxta-anal tumours, undergoing partial intersphincteric resection); and type 3 (intra-anal tumours, undergoing near-total intersphincteric resection with transanal mesorectal excision).ResultsSeventy-one patients with low rectal cancer underwent CAA: 17 type 1; 39 type 2; and 15 type 3. The median age of patients was 61.6 years, with a male/female ratio of 2:1. Neoadjuvant therapy was given to 56 (79%) patients. R0 resection was achieved in 69 (97.2%) patients. Adverse events occurred in 25 (35.2%) of the 71 patients with a higher complication rate in type 1 vs type 2 vs type 3 (47.1% vs 38.5% vs 13.3%, respectively; P = 0.035). Anastomotic separation was identified in six (8.5%) patients and pelvic haematoma/seroma in five (7%); two (8.3%) female patients developed a recto–vaginal fistula. Ten (14.1%) patients were indefinitely diverted, with a trend towards higher long-term anastomotic failure in type 1 vs type 2 vs type 3 (17.6% vs 15.5% vs 6.7%). The type of anastomosis did not influence the overall or disease-free survival.ConclusionCAA is a safe technique in which anorectal continuity can be preserved either as a primary restorative option in elective cases of low rectal cancer or as a salvage procedure following a failed stapled anastomosis with a less successful outcome in the latter. CAA has acceptable morbidity with good long-term survival in carefully selected patients.
Penney NC, Kinross J, Newton RC, et al., 2015, The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review, INTERNATIONAL JOURNAL OF OBESITY, Vol: 39, Pages: 1565-1574, ISSN: 0307-0565
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.