Imperial College London
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Dr James Kinross

Faculty of Medicine, Department of Surgery & Cancer

Reader in General Surgery
 
 
 
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Contact

 

+44 (0)20 3312 1947j.kinross

 
 
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Location

 

1029Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Clift:2018:10.1530/EC-17-0311,
author = {Clift, AK and Kornasiewicz, O and Drymousis, P and Faiz, O and Wasan, H and Kinross, J and Cecil, T and Frilling, A},
doi = {10.1530/EC-17-0311},
journal = {Endocrine Connections},
pages = {268--277},
title = {Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management.},
url = {http://dx.doi.org/10.1530/EC-17-0311},
volume = {7},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Goblet cell carcinomas (GCC) are a rare, aggressive sub-type of appendiceal tumours with neuroendocrine features, and controversy exists with regards to therapeutic strategy. We undertook a retrospective review of GCC patients surgically treated at two tertiary referral centres. Clinical and histopathological data were extracted from a prospectively maintained database. Survival analyses utilised Kaplan-Meier methodology. Twenty-one patients were identified (9 females). Median age at diagnosis was 55years (range 32-77). There were 3, 6 and 9 grade 1, 2 and 3 tumours, respectively. One, 10, 5 and 5 patients had stage I, II, III and IV disease at diagnosis, respectively. There were 8, 10 and 3 Tang class A, B and C tumours, respectively. Index operation was appendectomy (n=12), right hemicolectomy (n=6) or resections including appendix/right colon, omentum and the gynaecological system (n=3). Eight patients underwent completion right hemicolectomy. Surgery for recurrence included small bowel resection (n=2), debulking with peritonectomy and heated intraperitoneal chemotherapy, and hysterectomy and bilateral salpingo-oophorectomy (all n=1). Median follow-up was 30months (range 2.5-123). One-, 3- and 5-year OS was 79.4%, 60% and 60%, respectively. Mean OS (1-, 3-, and 5-year OS) for Tang class A, B and C tumours were 73.1months (85.7%, 85.7%, 51.4%), 83.7months (all 66.7%) and 28.5months (66.7%, 66.7%, not reached), respectively. Chromogranin A/B and 68Ga-DOTATATE PET/CT were not useful in follow-up, but CEA, CA 19-9, CA 125 and 18F-FDG PET/CT identified tumour recurrence. GCC must be clearly discriminated from relatively indolent appendiceal neuroendocrine neoplasms. 18F-FDG PET/CT and CEA/CA19-9/CA-125 are useful in detecting recurrence of GCC.
AU  - Clift,AK
AU  - Kornasiewicz,O
AU  - Drymousis,P
AU  - Faiz,O
AU  - Wasan,H
AU  - Kinross,J
AU  - Cecil,T
AU  - Frilling,A
DO  - 10.1530/EC-17-0311
EP  - 277
PY  - 2018///
SN  - 2049-3614
SP  - 268
TI  - Goblet cell carcinomas of the appendix: rare but aggressive neoplasms with challenging management.
T2  - Endocrine Connections
UR  - http://dx.doi.org/10.1530/EC-17-0311
UR  - http://hdl.handle.net/10044/1/56315
VL  - 7
ER  -
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