Publications
197 results found
Frampton AE, Krell J, Zhang Y, et al., 2012, The role of miR-10b in metastatic pancreatic ductal adenocarcinoma, SURGERY, Vol: 152, Pages: 936-938, ISSN: 0039-6060
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- Citations: 6
Silver B, Krell J, Frampton AE, 2012, Do miRNAs hold the key to controlling EBV-driven tumorigenesis?, FUTURE VIROLOGY, Vol: 7, Pages: 1045-1049, ISSN: 1746-0794
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- Citations: 1
Keeler BD, Krell J, Acheson AG, et al., 2012, Is there a role for intravenous iron therapy in patients undergoing colorectal cancer resection?, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 1407-1412, ISSN: 1473-7140
Frampton AE, Krell J, Giovannetti E, et al., 2012, Defining a prognostic molecular profile for ductal adenocarcinoma of the pancreas highlights known key signaling pathways, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 1275-1278, ISSN: 1473-7140
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- Citations: 3
Frampton AE, Pai M, Krell J, et al., 2012, The "malignant truth" about the recurrence of pancreatic intraductal papillary mucinous neoplasms., Archives of Surgery, Vol: 147, Pages: 977-979
Zabron AA, Frampton AE, Krell J, et al., 2012, MicroRNAs in malignant bile as diagnostic biomarkers for pancreatic ductal adenocarcinoma., UEGW, Pages: A119-A119
Twelves CJ, Stebbing J, 2012, BEING THERE FOR WOMEN WITH METASTATIC BREAST CANCER. A PAN-EUROPEAN PATIENT SURVEY, 37th Congress of the European-Society-for-Medical-Oncology (ESMO), Publisher: OXFORD UNIV PRESS, Pages: 132-132, ISSN: 0923-7534
Frampton AE, Krell J, 2012, Cancer vaccines: is prevention better than cure?, FUTURE ONCOLOGY, Vol: 8, Pages: 899-901, ISSN: 1479-6694
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- Citations: 1
Ezra DG, Krell J, Rose GE, et al., 2012, Transcriptome-level microarray expression profiling implicates IGF-1 and Wnt signalling dysregulation in the pathogenesis of thyroid-associated orbitopathy, JOURNAL OF CLINICAL PATHOLOGY, Vol: 65, Pages: 608-613, ISSN: 0021-9746
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- Citations: 29
Frampton AE, Krell J, Jacob J, et al., 2012, Loss of miR-126 is crucial to pancreatic cancer progression, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 881-884, ISSN: 1473-7140
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- Citations: 37
Krell J, Stebbing J, 2012, Circulating tumour cells as biomarkers in early breast cancer, LANCET ONCOLOGY, Vol: 13, Pages: 653-654, ISSN: 1470-2045
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- Citations: 7
Krell J, Frampton AE, Jiao LR, et al., 2012, Can pharmacogenomics guide effective anticancer therapy in pancreatic ductal adenocarcinoma?, PHARMACOGENOMICS, Vol: 13, Pages: 977-979, ISSN: 1462-2416
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- Citations: 1
Payne RE, Wang F, Su N, et al., 2012, Viable circulating tumour cell detection using multiplex RNA <i>in situ</i> hybridisation predicts progression-free survival in metastatic breast cancer patients, BRITISH JOURNAL OF CANCER, Vol: 106, Pages: 1790-1797, ISSN: 0007-0920
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- Citations: 48
Lee B, Lim AK, Krell J, et al., 2012, The efficacy of axillary ultrasound in the detection of nodal metastasis in breast cancer, 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Publisher: AMER SOC CLINICAL ONCOLOGY, ISSN: 0732-183X
Krell J, Stebbing J, 2012, Quackery Coffee: the science and art of moderation, LANCET ONCOLOGY, Vol: 13, Pages: 457-458, ISSN: 1470-2045
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- Citations: 3
Jacob J, Frampton AE, Castellano L, et al., 2012, Retinoblastoma protein determines aggressiveness in triple-negative breast cancer, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 581-584, ISSN: 1473-7140
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- Citations: 3
Krell J, Frampton AE, Stebbing J, 2012, The clinical significance of tumor infiltrating lymphoctyes in breast cancer: does subtype matter?, BMC CANCER, Vol: 12, ISSN: 1471-2407
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- Citations: 4
Krell J, Frampton AE, Jacob J, et al., 2012, miRNAs in breast cancer: ready for real time?, PHARMACOGENOMICS, Vol: 13, Pages: 709-719, ISSN: 1462-2416
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- Citations: 13
Krell J, Frampton AE, Cascorbi I, et al., 2012, miRNAs modulating endocrine resistance in breast cancer, PHARMACOGENOMICS, Vol: 13, Pages: 645-646, ISSN: 1462-2416
Krell J, Stebbing J, 2012, Quackery Ginger: the root of cancer therapy?, LANCET ONCOLOGY, Vol: 13, Pages: 235-236, ISSN: 1470-2045
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- Citations: 11
Frampton AE, Krell J, Pellegrino L, et al., 2012, Integrated analysis of miRNA and mRNA profiles enables target acquisition in human cancers, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 12, Pages: 323-330, ISSN: 1473-7140
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- Citations: 2
Jiao LR, Frampton AE, Jacob J, et al., 2012, MicroRNAs Targeting Oncogenes Are Down-Regulated in Pancreatic Malignant Transformation from Benign Tumors, PLOS ONE, Vol: 7, ISSN: 1932-6203
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- Citations: 109
Krell J, Frampton AE, Jacob J, et al., 2012, The Clinico-Pathologic Role of MicroRNAs miR-9 and miR-151-5p in Breast Cancer Metastasis, MOLECULAR DIAGNOSIS & THERAPY, Vol: 16, Pages: 167-172, ISSN: 1177-1062
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- Citations: 35
Pinato DJ, Krell J, Wasan H, et al., 2011, Neoplastic infiltration of the sphenoid wing: A rare manifestation of metastatic colorectal cancer, ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, Vol: 7, Pages: 399-400, ISSN: 1743-7555
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- Citations: 5
Frampton AE, Krell J, Jacob J, et al., 2011, microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 11, Pages: 1837-1842, ISSN: 1473-7140
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- Citations: 21
Lee B, Lim A, Krell J, et al., 2011, Re-evaluating the efficacy of axillary ultrasound in the detection of nodal metastasis and its impact on clinical practice., J Clin Oncol, Vol: 29
4 Background: Recent reports have indicated a lack of overall survival benefit for axillary node dissection versus sentinel lymph node biopsy in early breast cancer. To study this further, we wished to assess the accuracy and effectiveness of ultrasound guided fine needle aspiration (FNA) cytology in detecting lymph node involvement in breast cancer patients, in order to refine and evaluate our current clinical pathways as newly diagnosed invasive breast cancer patients routinely undergo pre-surgical axillary ultrasound. METHODS: An FNA was taken from nodes of consecutive patients, which appeared abnormal on ultrasonography based on size, morphology, fatty hilum and cortical thickness measurements. Ultrasound and FNA cytological findings were correlated with histology following axillary node dissection. Of 260 cases, 123 (47.3%) had metastatic nodal involvement. Of these cases, only 66 (53.7%) were reported as positive on US findings. RESULTS: The overall positive predictive value (PPV) of ultrasound for detecting metastatic nodal involvement measured 0.82, and the negative predictive value (NPV) was 0.60. The sensitivity was 0.54, specificity measured 0.85 and the accuracy was 0.68. The ultrasound morphological nodal features with the greatest correlation with malignancy were absence of a fatty hilum (p=0.003) and an increased cortical thickness (p=0.03). Cases with a metastatic nodal burden density of a least 20% were also more likely to be detected as abnormal on axillary ultrasound. (p=0.009). CONCLUSIONS: Axillary ultrasound has a low NPV and negative sonographic results do not exclude node metastases with sufficient sensitivity in most cases, to justify its routine clinical use. [Table: see text].
Lee B, Lim A, Krell J, et al., 2011, Re-evaluating the efficacy of axillary ultrasound in the detection of nodal metastasis and its impact on clinical practice, JOURNAL OF CLINICAL ONCOLOGY, Vol: 29, ISSN: 0732-183X
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- Citations: 1
Stebbing J, Thiyagarajan A, Surendrakumar V, et al., 2011, Epidermal growth factor receptor status in early stage breast cancer is associated with cellular proliferation but not cross-talk, JOURNAL OF CLINICAL PATHOLOGY, Vol: 64, Pages: 829-831, ISSN: 0021-9746
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- Citations: 4
Jacob J, Krell J, Castellano L, et al., 2011, Determination of cut-offs for circulating tumor cell measurement in metastatic cancer, EXPERT REVIEW OF ANTICANCER THERAPY, Vol: 11, Pages: 1345-1350, ISSN: 1473-7140
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- Citations: 9
Alifrangis C, Krell J, Stebbing J, 2011, The pharmacoeconomics of spiralling cancer drug costs - Is there a viable solution?, EUROPEAN JOURNAL OF CANCER, Vol: 47, Pages: 1285-1286, ISSN: 0959-8049
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- Citations: 2
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