Imperial College London
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DrJonathanKrell

Faculty of Medicine, Department of Surgery & Cancer

Clinical SL in Medical Oncology (Gynaecological Oncology)
 
 
 
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Contact

 

j.krell

 
 
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Location

 

Institute of Reproductive and Developmental BiologyHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Le:2016:10.1080/14737159.2016.1175940,
author = {Le, Large TYS and Prado, MM and Krell, J and Bijlsma, MF and Meijer, LL and Kazemier, G and Frampton, AE and Giovannetti, E},
doi = {10.1080/14737159.2016.1175940},
journal = {Expert Review of Molecular Diagnostics},
pages = {733--736},
title = {Bioinformatic analysis reveals pancreatic cancer molecular subtypes specific to the tumor and the microenvironment},
url = {http://dx.doi.org/10.1080/14737159.2016.1175940},
volume = {16},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease characterized by a dense desmoplastic reaction surrounding malignant epithelial cells. Interaction between the epithelial and stromal compartments is suggested to enhance its aggressive nature. Indeed, therapies targeting the stroma, as well as the tumor cells, may improve survival outcomes for patients. The evaluated study by Moffitt et al. used bioinformatic techniques to separate gene expression patterns of normal tissues from PDAC and stroma in a large cohort of samples. The researchers identified two different subtypes of PDAC (‘classical’ and ‘basal-like’) and surrounding stroma (‘normal’ and ‘activated’). The basal-like subtype was associated with worse prognosis and a trend towards better response to adjuvant therapy. Hopefully, the molecular stratification of PDAC will potentially allow more personalized treatment strategies and guide clinical decision making.
AU  - Le,Large TYS
AU  - Prado,MM
AU  - Krell,J
AU  - Bijlsma,MF
AU  - Meijer,LL
AU  - Kazemier,G
AU  - Frampton,AE
AU  - Giovannetti,E
DO  - 10.1080/14737159.2016.1175940
EP  - 736
PY  - 2016///
SN  - 1473-7159
SP  - 733
TI  - Bioinformatic analysis reveals pancreatic cancer molecular subtypes specific to the tumor and the microenvironment
T2  - Expert Review of Molecular Diagnostics
UR  - http://dx.doi.org/10.1080/14737159.2016.1175940
VL  - 16
ER  -
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