Imperial College London

Krishnan

Faculty of EngineeringDepartment of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 6633j.krishnan

 
 
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Location

 

C503Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

57 results found

Liu C, Krishnan J, Stebbing J, Xu XYet al., 2011, Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors, PHARMACOGENOMICS, Vol: 12, Pages: 1337-1348, ISSN: 1462-2416

Journal article

Seaton DD, Krishnan J, 2011, The coupling of pathways and processes through shared components, BMC SYSTEMS BIOLOGY, Vol: 5, ISSN: 1752-0509

Journal article

Krishnan J, 2011, Effects of saturation and enzyme limitation in feedforward adaptive signal transduction, IET SYSTEMS BIOLOGY, Vol: 5, Pages: 208-219, ISSN: 1751-8849

Journal article

Krishnan J, Alam-Nazki A, 2011, An investigation of design principles underlying repulsive and attractive gradient sensing and their switching, JOURNAL OF THEORETICAL BIOLOGY, Vol: 273, Pages: 80-99, ISSN: 0022-5193

Journal article

Seaton D, Krishnan J, 2011, Modular systems approach to understanding the interaction of adaptive and monostable and bistable threshold processes, IET SYSTEMS BIOLOGY, Vol: 5, Pages: 81-U25, ISSN: 1751-8849

Journal article

Seaton D, Krishnan J, 2011, Modelling the influence of allostery on crosstalk in the phosphatodylinositol pathway, IASTED International Computational Bioscience Conference, Publisher: ACTA Press

Conference paper

Alam-Nazki A, Krishnan J, 2010, A mathematical modelling framework for understanding chemorepulsive signal transduction in Dictyostelium, JOURNAL OF THEORETICAL BIOLOGY, Vol: 266, Pages: 140-153, ISSN: 0022-5193

Journal article

de Silva E, Krishnan J, Betney R, Stansfield Iet al., 2010, A mathematical modelling framework for elucidating the role of feedback control in translation termination, JOURNAL OF THEORETICAL BIOLOGY, Vol: 264, Pages: 808-821, ISSN: 0022-5193

Journal article

Betney R, de Silva E, Krishnan J, Stansfield Iet al., 2010, Autoregulatory systems controlling translation factor expression: Thermostat-like control of translational accuracy, RNA, Pages: ---

In both prokaryotes and eukaryotes, the expression of a large number of genes is controlled by negative feedback, in some cases operating at the level of translation of the mRNA transcript. Of particular interest are those cases where the proteins concerned have cell-wide function in recognizing a particular codon or RNA sequence. Examples include the bacterial translation termination release factor RF2, initiation factor IF3, and eukaryote poly(A) binding protein. The regulatory loops that control their synthesis establish a negative feedback control mechanism based upon that protein’s RNA sequence recognition function in translation (for example, stop codon recognition) without compromising the accurate recognition of that codon, or sequence during general, cell-wide translation. Here, the bacterial release factor RF2 and initiation factor IF3 negative feedback loops are reviewed and compared with similar negative feedback loops that regulate the levels of the eukaryote release factor, eRF1, established artificially by mutation. The control properties of such negative feedback loops are discussed as well as their evolution. The role of negative feedback to control translation factor expression is considered in the context of a growing body of evidence that both IF3 and RF2 can play a role in stimulating stalled ribosomes to abandon translation in response to amino acid starvation. Here, we make the case that negative feedback control serves primarily to limit the overexpression of these translation factors, preventing the loss of fitness resulting from an unregulated increase in the frequency of ribosome drop-off.

Journal article

Krishnan J, Seaton D, 2010, The effect of feedback regulation in irreversible biological networks, Int. Rev. of Automatic Control, Pages: 38-44

Journal article

Krishnan J, 2009, Signal processing through a generalized module of adaptation and spatial sensing, JOURNAL OF THEORETICAL BIOLOGY, Vol: 259, Pages: 31-43, ISSN: 0022-5193

Journal article

Krishnan J, Iglesias PA, 2009, Systems Analysis of Regulatory Processes Underlying Eukaryotic Gradient Perception, IEEE T AUTOMAT CONTR, Pages: 126-138, ISSN: 0018-9286

This paper analyzes regulatory processes involved in the biological process of directed cell locomotion-known as chemotaxis. We focus on the nature of regulation involved in a subprocess of chemotaxis called gradient perception. We examine two different models from a dynamics/control perspective to gain insight into the working mechanisms of these models. One model is a minimal model which reconciles gradient perception to the property of adaptation. The second model is a biochemical model of a lipid network and its regulation by enzymes. In both cases, we focus on the extent of regulation of the modules/networks by inputs, and examine various limiting cases. Both the models and the resulting insights hake broader applicability than the context in which they were developed.

Journal article

Krishnan J, Iglesias PA, 2008, Systems analysis of regulatory processes underlying eukaryotic gradient perception, IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, Pages: 126-138, ISSN: 1549-8328

Journal article

Krishnan J, Iglesias PA, 2007, Receptor-mediated and intrinsic polarization and their interaction in chemotaxing cells, BIOPHYSICAL JOURNAL, Vol: 92, Pages: 816-830, ISSN: 0006-3495

Journal article

Krishnan J, 2007, Modelling gradient perception and polarization in chemotaxing Dictyostelium cells, BMC SYSTEMS BIOLOGY, Vol: 1, ISSN: 1752-0509

Journal article

J Krishnan, PA Iglesias, 2005, A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells II: input-output analysis, Journal of Theoretical Biology, Vol: 235, Pages: 504-520, ISSN: 0022-5193

Journal article

Krishnan J, Iglesias PA, 2004, Uncovering directional sensing: where are we headed?, Systems Biology, Pages: 54-61, ISSN: 1741-2471

Journal article

Paliwal S, Ma L, Krishnan J, Levchenko A, Iglesias PAet al., 2004, Responding to directional cues: a tale of two cells, Control Systems Magazine, Pages: 77-90, ISSN: 1066-033X

Journal article

Krishnan J, Runborg O, Kevrekidis IG, 2004, Bifurcation analysis of nonlinear reaction-diffusion problems using wavelet-based reduction techniques, Computers and Chemical Engineering, Vol: 28, Pages: 557-574, ISSN: 0098-1354

Journal article

J Krishnan, PAIglesias, 2004, A modeling framework describing the enzyme regulation of membrane lipids underlying gradient perception in Dictyostelium cells, Journal of Theoretical Biology, Vol: 229, Pages: 85-99, ISSN: 0022-5193

Journal article

Krishnan J, Iglesias PA, 2003, Analysis of the signal transduction properties of a module of spatial sensing in eukaryotic chemotaxis, Bulletin of Mathematical Biology, Vol: 65, Pages: 95-128, ISSN: 0092-8240

Journal article

Or-guil M, Krishnan J, Kevrekidis IG, Bar Met al., 2001, A computational study of pulse dynamics in ring-shaped domains, Physical review E, Vol: 64, Pages: 212-222

Journal article

J Krishnan, K Engelborghs, M Bar, K Lust, D Roose, I G Kevrekidiset al., 2001, A computer-assisted study of pulse dynamics in anisotropic media, Physica D, Vol: 154, Pages: 85-110, ISSN: 0167-2789

Journal article

Krishnan J, Iglesias PA, Ma L, 2001, Analysis of a reaction-diffusion model of spatial sensing, International Conference on Systems Biology, Pages: 147-159

Conference paper

Krishnan J, Kevrekidis IG, Imbihl R, Baer Met al., 2000, Pulse dynamics and interaction on anisotropic surfaces: a computer-assisted study, Chemical Engineering Science, Vol: 55, Pages: 255-266

Journal article

J Krishnan, M Or-guil, M Zimmermann, I G Kevrekidis, M Baret al., 1999, Bifurcation and stability analysis of pulses in a one-dimensional excitable medium, Computer methods in applied mechanics and engineering, Vol: 170, Pages: 253-275

Journal article

Krishnan J, Chidambaram M, 1996, Periodic operation of polymerization reactors with input multiplicities, Hung. J. of Chemical Engg., Pages: 1-4

Journal article

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