Imperial College London

Krishnan

Faculty of EngineeringDepartment of Chemical Engineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 6633j.krishnan

 
 
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Location

 

C503Roderic Hill BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Menon:2017:10.1038/s41598-017-11081-8,
author = {Menon, G and Okeke, C and Krishnan, J},
doi = {10.1038/s41598-017-11081-8},
journal = {Scientific Reports},
title = {Modelling compartmentalization towards elucidation and engineering of spatial organization in biochemical pathways},
url = {http://dx.doi.org/10.1038/s41598-017-11081-8},
volume = {7},
year = {2017}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - Compartmentalization is a fundamental ingredient, central to the functioning of biological systems at multiple levels. At the cellular level, compartmentalization is a key aspect of the functioning of biochemical pathways and an important element used in evolution. It is also being exploited in multiple contexts in synthetic biology. Accurate understanding of the role of compartments and designing compartmentalized systems needs reliable modelling/systems frameworks. We examine a series of building blocks of signalling and metabolic pathways with compartmental organization. We systematically analyze when compartmental ODE models can be used in these contexts, by comparing these models with detailed reaction-transport models, and establishing a correspondence between the two. We build on this to examine additional complexities associated with these pathways, and also examine sample problems in the engineering of these pathways. Our results indicate under which conditions compartmental models can and cannot be used, why this is the case, and what augmentations are needed to make them reliable and predictive. We also uncover other hidden consequences of employing compartmental models in these contexts. Or results contribute a number of insights relevant to the modelling, elucidation, and engineering of biochemical pathways with compartmentalization, at the core of systems and synthetic biology.
AU - Menon,G
AU - Okeke,C
AU - Krishnan,J
DO - 10.1038/s41598-017-11081-8
PY - 2017///
SN - 2045-2322
TI - Modelling compartmentalization towards elucidation and engineering of spatial organization in biochemical pathways
T2 - Scientific Reports
UR - http://dx.doi.org/10.1038/s41598-017-11081-8
UR - http://hdl.handle.net/10044/1/58120
VL - 7
ER -