Dr Jessica Laine has recently joined Imperial College as a research fellow in the MRC-PHE centre for Environment and Health. Prior to joining Imperial College, she was awarded a PhD in Epidemiology from the Gillings School of Public Health at the University of North Carolina, Chapel Hill (UNC). At UNC, Dr Laine's research was focused on investigating epidemiological mechanisms of diseases associated with exposure to inorganic arsenic (iAs) during the prenatal period. This work included, establishing OMICs associated with iAs exposure, nutritional biomarkers that influence iAs metabolism, iAs associated changes in birthweight, and understanding mechanisms using causal inference and mediation analysis. Laine also has a MS in Biology, where her research was focused on broadly in ecotoxicology, a graduate certificate in Women's Studies, and a BS in Biology from Appalachian State University.
Dr Laine's research interests are broadly in molecular, environmental, and nutritional epidemiology, and in the development of epidemiological methods. Her interests are strongly rooted in epidemiological methods to understand mechanisms via the application of causality and causal inference. She leads a working group at Imperial on causality (please contact her if you are interested).
At Imperial College, Laine is currently researching the impacts of the exposome during early life, using cross-OMIC methods, and is investigating the external exposome in association with cross-OMICs in the European project EXPOsOMICS. She is also uncovering urban determinants of health within EXPOsOMICS. Dr Laine is the Co-leader for the Global Health BSc course in the School of Public Health. She is also passionate about effective science communication and outreach, and women in science.
et al., 2017, Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure, Environmental Science & Technology, Vol:51, ISSN:0013-936X, Pages:625-633
Laine JE, Fry RC, 2016, A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure, Annals of Global Health, Vol:82, ISSN:2214-9996, Pages:189-196
et al., 2014, Prenatal Arsenic Exposure and Shifts in the Newborn Proteome: Interindividual Differences in Tumor Necrosis Factor (TNF)-Responsive Signaling, Toxicological Sciences, Vol:139, ISSN:1096-6080, Pages:328-337
et al., 2014, Maternal Arsenic Exposure, Arsenic Methylation Efficiency, and Birth Outcomes in the Biomarkers of Exposure to ARsenic (BEAR) Pregnancy Cohort in Mexico, Environmental Health Perspectives
et al., 2014, Prenatal arsenic exposure and the epigenome: Altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood, Environmental and Molecular Mutagenesis, Vol:55, ISSN:0893-6692, Pages:196-208