Dr Jessica Laine has recently joined Imperial College as a research fellow in the MRC-PHE centre for Environment and Health. Prior to joining Imperial College, she was awarded a PhD in Epidemiology from the Gillings School of Public Health at the University of North Carolina, Chapel Hill (UNC). At UNC, Dr Laine's research was focused on investigating epidemiological mechanisms of diseases associated with exposure to inorganic arsenic (iAs) during the prenatal period. This work included, establishing 'omics associated with iAs exposure, nutritional biomarkers that influence iAs metabolism, iAs associated changes in birthweight, and understanding mechanisms using causal inference and mediation analysis. Laine also has a MS in Biology, where her research was focused on broadly in ecotoxicology, a graduate certificate in Women's Studies, and a BS in Biology from Appalachian State University.
Dr Laine's research interests are broadly in molecular, environmental, and nutritional epidemiology, and in epidemiological methods. Her pedagogic motivations are strongly rooted in epidemiological methods to understand mechanisms via the application of causality and causal inference. She leads a working group and seminar series and journal club (along with other postdoc and PhD students) at Imperial on methods and causality (please contact her if you are interested in participating).
At Imperial College, Jessica's research is focused on improving causal inference in exposome studies. She is currently researching the impacts of the exposome during early life, using cross-omic methods, and is investigating the external exposome in association with 'omics and disease risks in the European project EXPOsOMICS. She is also uncovering urban and social determinants of health within EXPOsOMICS and LIFEPATH. Furthermore, she applies causal inference methods, including mediation analysis, to better understand mediators of exposure/disease relationships.
Dr Laine is the Co-leader for the Global Health BSc course in the School of Public Health.She is also a postdoc representative for the Department of Epidemiology and Biostatistics. Laine is also passionate about effective science communication and outreach, and women in science.
et al., 2017, Neonatal Metabolomic Profiles Related to Prenatal Arsenic Exposure, Environmental Science & Technology, Vol:51, ISSN:0013-936X, Pages:625-633
Laine JE, Fry RC, 2016, A Systems Toxicology-based Approach Reveals Biological Pathways Dysregulated by Prenatal Arsenic Exposure, Annals of Global Health, Vol:82, ISSN:2214-9996, Pages:189-196
et al., 2015, Placental Cadmium Levels Are Associated with Increased Preeclampsia Risk, Plos One, Vol:10, Pages:e0139341-e0139341
et al., 2014, Prenatal Arsenic Exposure and Shifts in the Newborn Proteome: Interindividual Differences in Tumor Necrosis Factor (TNF)-Responsive Signaling, Toxicological Sciences, Vol:139, ISSN:1096-6080, Pages:328-337