Imperial College London

ProfessorJohnLindon

Faculty of MedicineDepartment of Surgery & Cancer

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 3194j.lindon Website

 
 
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Location

 

Office no. 362Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Research Interests:

Metabonomics, NMR spectroscopy, computational chemistry, multivariate statistics, drug metabolism, applications in biomedicine

  • Development of new NMR spectroscopic methods
  • Analysis of NMR spectra of biofluids in normal and abnormal situations
  • Magic-angle-spinning NMR of tissues 
  • Identification of xenobiotic metabolites
  • Applications of directly coupled HPLC-NMR and HPLC-NMR-MS
  • Multivariate statistical approaches in metabonomics
  • Prediction of xenobiotic metabolism
  • Reactive drug metabolites 

Publications

Lewis MR, Pearce JT, Spagou K, et al., 2016, Development and Application of UPLC-ToF MS for Precision Large Scale Urinary Metabolic Phenotyping., Anal Chem

Hansen PE, Borisov EV, Lindon JC, 2015, Determination of the tautomeric equilibria of pyridoyl benzoyl beta-diketones in the liquid and solid state through the use of deuterium isotope effects on H-1 and C-13 NMR chemical shifts and spin coupling constants, Spectrochimica Acta Part A-molecular and Biomolecular Spectroscopy, Vol:136, ISSN:1386-1425, Pages:107-112

Hall AM, Vilasi A, Garcia-Perez I, et al., 2015, The urinary proteome and metabonome differ from normal in adults with mitochondrial disease, Kidney International, Vol:87, ISSN:0085-2538, Pages:610-622

Garcia-Perez I, Lindon JC, Minet E, 2014, Application of CE-MS to a metabonomics study of human urine from cigarette smokers and non-smokers., Bioanalysis, Vol:6, Pages:2733-2749

Lindon JC, Nicholson JK, 2014, The emergent role of metabolic phenotyping in dynamic patient stratification, Expert Opinion On Drug Metabolism & Toxicology, Vol:10, ISSN:1742-5255, Pages:915-919

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