Imperial College London

ProfessorJohnLindon

Faculty of MedicineDepartment of Surgery & Cancer

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 3194j.lindon Website

 
 
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Location

 

Office no. 362Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Research Interests:

Metabonomics, NMR spectroscopy, computational chemistry, multivariate statistics, drug metabolism, applications in biomedicine

  • Development of new NMR spectroscopic methods
  • Analysis of NMR spectra of biofluids in normal and abnormal situations
  • Magic-angle-spinning NMR of tissues 
  • Identification of xenobiotic metabolites
  • Applications of directly coupled HPLC-NMR and HPLC-NMR-MS
  • Multivariate statistical approaches in metabonomics
  • Prediction of xenobiotic metabolism
  • Reactive drug metabolites 

Publications

Kaluarachchi MR, Boulangé CL, Garcia-Perez I, et al., 2016, Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers., Bioanalysis

Lewis MR, Pearce JT, Spagou K, et al., 2016, Development and Application of Ultra-Performance Liquid Chromatography-TOF MS for Precision Large Scale Urinary Metabolic Phenotyping., Anal Chem, Vol:88, Pages:9004-9013

Karaman I, Ferreira DL, Boulange CL, et al., 2016, A Workflow For Integrated Processing of Multi-Cohort Untargeted (1)H NMR Metabolomics Data In Large Scale Metabolic Epidemiology., J Proteome Res

Hansen PE, Borisov EV, Lindon JC, 2015, Determination of the tautomeric equilibria of pyridoyl benzoyl beta-diketones in the liquid and solid state through the use of deuterium isotope effects on H-1 and C-13 NMR chemical shifts and spin coupling constants, Spectrochimica Acta Part A-molecular and Biomolecular Spectroscopy, Vol:136, ISSN:1386-1425, Pages:107-112

Hall AM, Vilasi A, Garcia-Perez I, et al., 2015, The urinary proteome and metabonome differ from normal in adults with mitochondrial disease, Kidney International, Vol:87, ISSN:0085-2538, Pages:610-622

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