Imperial College London

ProfessorJohnLindon

Faculty of MedicineDepartment of Surgery & Cancer

Senior Research Investigator
 
 
 
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Contact

 

+44 (0)20 7594 3194j.lindon Website

 
 
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Location

 

Office no. 362Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Summary

Research Interests:

Metabonomics, NMR spectroscopy, computational chemistry, multivariate statistics, drug metabolism, applications in biomedicine

  • Development of new NMR spectroscopic methods
  • Analysis of NMR spectra of biofluids in normal and abnormal situations
  • Magic-angle-spinning NMR of tissues 
  • Identification of xenobiotic metabolites
  • Applications of directly coupled HPLC-NMR and HPLC-NMR-MS
  • Multivariate statistical approaches in metabonomics
  • Prediction of xenobiotic metabolism
  • Reactive drug metabolites 

Publications

Journals

Castagné R, Boulangé CL, Karaman I, et al., 2017, Improving Visualization and Interpretation of Metabolome-Wide Association Studies: An Application in a Population-Based Cohort Using Untargeted (1)H NMR Metabolic Profiling., J Proteome Res, Vol:16, Pages:3623-3633

Posma JM, Garcia-Perez I, Heaton JC, et al., 2017, Integrated Analytical and Statistical Two-Dimensional Spectroscopy Strategy for Metabolite Identification: Application to Dietary Biomarkers, Analytical Chemistry, Vol:89, ISSN:0003-2700, Pages:3300-3309

Rodriguez-Martinez A, Posma JM, Ayala R, et al., 2017, J-Resolved 1H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis., Anal Chem

Dumas M-E, Domange C, Calderari S, et al., 2016, Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series, Genome Medicine, Vol:8, ISSN:1756-994X

More Publications