Imperial College London


Faculty of MedicineDepartment of Surgery & Cancer

Senior Research Investigator



+44 (0)20 7594 3194j.lindon Website




Office no. 362Sir Alexander Fleming BuildingSouth Kensington Campus





Research Interests:

Metabonomics, NMR spectroscopy, computational chemistry, multivariate statistics, drug metabolism, applications in biomedicine

  • Development of new NMR spectroscopic methods
  • Analysis of NMR spectra of biofluids in normal and abnormal situations
  • Magic-angle-spinning NMR of tissues 
  • Identification of xenobiotic metabolites
  • Applications of directly coupled HPLC-NMR and HPLC-NMR-MS
  • Multivariate statistical approaches in metabonomics
  • Prediction of xenobiotic metabolism
  • Reactive drug metabolites 


Lewis MR, Pearce JT, Spagou K, et al., 2016, Development and Application of UPLC-ToF MS for Precision Large Scale Urinary Metabolic Phenotyping., Anal Chem

Hansen PE, Borisov EV, Lindon JC, 2015, Determination of the tautomeric equilibria of pyridoyl benzoyl beta-diketones in the liquid and solid state through the use of deuterium isotope effects on H-1 and C-13 NMR chemical shifts and spin coupling constants, Spectrochimica Acta Part A-molecular and Biomolecular Spectroscopy, Vol:136, ISSN:1386-1425, Pages:107-112

Hall AM, Vilasi A, Garcia-Perez I, et al., 2015, The urinary proteome and metabonome differ from normal in adults with mitochondrial disease, Kidney International, Vol:87, ISSN:0085-2538, Pages:610-622

Garcia-Perez I, Lindon JC, Minet E, 2014, Application of CE-MS to a metabonomics study of human urine from cigarette smokers and non-smokers., Bioanalysis, Vol:6, Pages:2733-2749

Lindon JC, Nicholson JK, 2014, The emergent role of metabolic phenotyping in dynamic patient stratification, Expert Opinion On Drug Metabolism & Toxicology, Vol:10, ISSN:1742-5255, Pages:915-919

More Publications