Imperial College London


Faculty of MedicineDepartment of Medicine

Research Fellow



+44 (0)20 7594 3058j.macdonald Website




Sir Alexander Fleming BuildingSouth Kensington Campus





I am a synthetic biologist working on cell-free protein expression systems and computational protein design. I develop computational methods as well as working in the wet-lab.

Please visit my personal web page to learn more about my research:



Moore SJ, MacDonald JT, Wienecke S, et al., 2018, Rapid acquisition and model-based analysis of cell-free transcription-translation reactions from nonmodel bacteria, Proceedings of the National Academy of Sciences of the United States of America, Vol:115, ISSN:0027-8424, Pages:E4340-E4349

Salih O, He S, Planamente S, et al., 2018, Atomic Structure of Type VI Contractile Sheath from Pseudomonas aeruginosa, Structure, Vol:26, ISSN:0969-2126, Pages:329-+

Moore SJ, MacDonald JT, Freemont PS, 2017, Cell-free synthetic biology for in vitro prototype engineering, Biochemical Society Transactions, Vol:45, ISSN:0300-5127, Pages:785-791

MacDonald JT, Siciliano V, 2017, Computational Sequence Design with R2oDNA Designer., Methods Mol Biol, Vol:1651, Pages:249-262

Kelwick R, Webb AJ, MacDonald JT, et al., 2016, Development of a Bacillus subtilis cell-free transcription-translation system for prototyping regulatory elements, Metabolic Engineering, Vol:38, ISSN:1096-7176, Pages:370-381

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