Imperial College London

ProfessorJulianMarchesi

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Professor of Digestive Health
 
 
 
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Contact

 

+44 (0)20 3312 6197j.marchesi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Summary

Julian Marchesi graduated from Cardiff University with a PhD in biochemistry (1992) and became interested in the role bacteria play in ecosystem function. During his post-doctoral years he developed an interest in the contribution of uncultured microbes to the maintenance and function of ecosystems i.e. molecular microbial ecology. He subsequently secured a Wellcome Trust Fellowship which extended his molecular microbial ecology interest and investigated, with culture independent methods, the diversity and distribution of genes involved in biodegradation of priority pollutants in pristine environments. After a short time investigating the deep biosphere he obtained a Lectureship (2001) in the Department of Microbiology, University College Cork, Ireland where he transferred these “omic” skills into the human gut and started to investigate the human gut ecosystem in health and disease. After 7 years in UCC, he moved back to Cardiff University in 2008 to a senior lectureship, where he investigates the role of the gut microbiome in maintaining host health and initiating diseases not only of the gut, but throughout the host system.  In 2015 he was promoted to Professor at Cardiff and in 2016 to Professor at Imperial College London.

His work uses a variety of “omic” approaches such as metagenomics, metatranscriptomics, metabonomics and molecular ecology.  Over his 22 year career he has authored over 190 journal articles and peer-reviewed publications and is a senior editor for ISME Journal. He is the current chair of the BSG's Gut Microbiota for Health Expert Panel and chaired the Microbiology Society's "Unlocking the Microbiome " working group and the subsequent publication.

Publications

Journals

Monaghan TM, Duggal NA, Rosati E, et al., 2021, A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection, Cells, Vol:10, ISSN:2073-4409

Radhakrishnan ST, Alexander JL, Mullish BH, et al., 2021, Systematic Review: The association between the gut microbiota and medical therapies in inflammatory bowel disease, Alimentary Pharmacology and Therapeutics, ISSN:0269-2813

Mitra A, MacIntyre DA, Paraskevaidi M, et al., 2021, The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia, Genome Medicine: Medicine in the Post-genomic Era, Vol:13, ISSN:1756-994X

Ghani R, Mullish BH, Davies FJ, et al., 2021, How to adapt an intestinal microbiota transplantation program to reduce the risk of invasive multidrug-resistant infection, Clinical Microbiology and Infection, ISSN:1198-743X

Short C-E, Quinlan R, Preda V, et al., 2021, Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration, Frontiers in Cellular and Infection Microbiology, ISSN:2235-2988

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