Imperial College London
Alternate

ProfessorJulianMarchesi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Digestive Health
 
 
 
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Contact

 

+44 (0)20 3312 6197j.marchesi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Monaghan:2021:10.3390/microorganisms9071485,
author = {Monaghan, TM and Biswas, RN and Nashine, RR and Joshi, SS and Mullish, BH and Seekatz, AM and Miguens, Blanco J and McDonald, JAK and Marchesi, JR and Yau, TO and Christodoulou, N and Hatziapostolou, M and Pui-Bakovi, M and Vukovi, F and Klicek, F and Lauc, G and Xue, N and Dottorini, T and Ambalkar, S and Satav, A and Polytarchou, C and Acharjee, A and Kashyap, RS},
doi = {10.3390/microorganisms9071485},
journal = {Microorganisms},
pages = {1--21},
title = {Multiomics profiling reveals signatures of dysmetabolism in urban populations in central India},
url = {http://dx.doi.org/10.3390/microorganisms9071485},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Non-communicable diseases (NCDs) have become a major cause of morbidity and mortality in India. Perturbation of host–microbiome interactions may be a key mechanism by which lifestyle-related risk factors such as tobacco use, alcohol consumption, and physical inactivity may influence metabolic health. There is an urgent need to identify relevant dysmetabolic traits for predicting risk of metabolic disorders, such as diabetes, among susceptible Asian Indians where NCDs are a growing epidemic. Methods: Here, we report the first in-depth phenotypic study in which we prospectively enrolled 218 adults from urban and rural areas of Central India and used multiomic profiling to identify relationships between microbial taxa and circulating biomarkers of cardiometabolic risk. Assays included fecal microbiota analysis by 16S ribosomal RNA gene amplicon sequencing, quantification of serum short chain fatty acids by gas chromatography-mass spectrometry, and multiplex assaying of serum diabetic proteins, cytokines, chemokines, and multi-isotype antibodies. Sera was also analysed for N-glycans and immunoglobulin G Fc N-glycopeptides. Results: Multiple hallmarks of dysmetabolism were identified in urbanites and young overweight adults, the majority of whom did not have a known diagnosis of diabetes. Association analyses revealed several host–microbe and metabolic associations. Conclusions: Host–microbe and metabolic interactions are differentially shaped by body weight and geographic status in Central Indians. Further exploration of these links may help create a molecular-level map for estimating risk of developing metabolic disorders and designing early interventions.
AU  - Monaghan,TM
AU  - Biswas,RN
AU  - Nashine,RR
AU  - Joshi,SS
AU  - Mullish,BH
AU  - Seekatz,AM
AU  - Miguens,Blanco J
AU  - McDonald,JAK
AU  - Marchesi,JR
AU  - Yau,TO
AU  - Christodoulou,N
AU  - Hatziapostolou,M
AU  - Pui-Bakovi,M
AU  - Vukovi,F
AU  - Klicek,F
AU  - Lauc,G
AU  - Xue,N
AU  - Dottorini,T
AU  - Ambalkar,S
AU  - Satav,A
AU  - Polytarchou,C
AU  - Acharjee,A
AU  - Kashyap,RS
DO  - 10.3390/microorganisms9071485
EP  - 21
PY  - 2021///
SN  - 2076-2607
SP  - 1
TI  - Multiomics profiling reveals signatures of dysmetabolism in urban populations in central India
T2  - Microorganisms
UR  - http://dx.doi.org/10.3390/microorganisms9071485
UR  - https://www.mdpi.com/2076-2607/9/7/1485
UR  - http://hdl.handle.net/10044/1/90817
VL  - 9
ER  -
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