Imperial College London
Alternate

ProfessorJulianMarchesi

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Digestive Health
 
 
 
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Contact

 

+44 (0)20 3312 6197j.marchesi

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ferreira:2021:10.1016/j.ijrobp.2021.07.1713,
author = {Ferreira, MR and Sands, CJ and Li, J and Andreyev, JN and Chekmeneva, E and Gulliford, S and Marchesi, J and Lewis, MR and Dearnaley, DP},
doi = {10.1016/j.ijrobp.2021.07.1713},
journal = {International Journal of Radiation: Oncology - Biology - Physics},
pages = {1204--1213},
title = {Impact of pelvic radiation therapy for prostate cancer on global metabolic profiles and microbiota-driven gastrointestinal late side effects: a longitudinal observational study},
url = {http://dx.doi.org/10.1016/j.ijrobp.2021.07.1713},
volume = {111},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeRadiation therapy to the prostate and pelvic lymph nodes (PLNRT) is part of the curative treatment of high-risk prostate cancer. Yet, the broader influence of radiation therapy on patient physiology is poorly understood. We conducted comprehensive global metabolomic profiling of urine, plasma, and stools sampled from patients undergoing PLNRT for high-risk prostate cancer.Methods and MaterialsSamples were taken from 32 patients at 6 timepoints: baseline, 2 to 3 and 4 to 5 weeks of PLNRT; and 3, 6, and 12 months after PLNRT. We characterized the global metabolome of urine and plasma using 1H nuclear magnetic resonance spectroscopy and ultraperformance liquid chromatography-mass spectrometry, and of stools with nuclear magnetic resonance. Linear mixed-effects modeling was used to investigate metabolic changes between timepoints for each biofluid and assay and determine metabolites of interest.ResultsMetabolites in urine, plasma and stools changed significantly after PLNRT initiation. Metabolic profiles did not return to baseline up to 1 year post-PLNRT in any biofluid. Molecules associated with cardiovascular risk were increased in plasma. Pre-PLNRT fecal butyrate levels directly associated with increasing gastrointestinal side effects, as did a sharper fall in those levels during and up to 1 year postradiation therapy, mirroring our previous results with metataxonomics.ConclusionsWe showed for the first time that an overall metabolic effect is observed in patients undergoing PLNRT up to 1 year posttreatment. These metabolic changes may effect on long-term morbidity after treatment, which warrants further investigation.
AU  - Ferreira,MR
AU  - Sands,CJ
AU  - Li,J
AU  - Andreyev,JN
AU  - Chekmeneva,E
AU  - Gulliford,S
AU  - Marchesi,J
AU  - Lewis,MR
AU  - Dearnaley,DP
DO  - 10.1016/j.ijrobp.2021.07.1713
EP  - 1213
PY  - 2021///
SN  - 0360-3016
SP  - 1204
TI  - Impact of pelvic radiation therapy for prostate cancer on global metabolic profiles and microbiota-driven gastrointestinal late side effects: a longitudinal observational study
T2  - International Journal of Radiation: Oncology - Biology - Physics
UR  - http://dx.doi.org/10.1016/j.ijrobp.2021.07.1713
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000720934200029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.sciencedirect.com/science/article/pii/S0360301621026262?via%3Dihub
UR  - http://hdl.handle.net/10044/1/93682
VL  - 111
ER  -
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