Imperial College London
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ProfessorJamilMayet

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 1006j.mayet

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

NHLI offices,Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Baksi:2015:10.1016/j.ijcard.2015.09.064,
author = {Baksi, AJ and Davies, JE and Hadjiloizou, N and Baruah, R and Unsworth, B and Foale, RA and Korolkova, O and Siggers, JH and Francis, DP and Mayet, J and Parker, KH and Hughes, AD},
doi = {10.1016/j.ijcard.2015.09.064},
journal = {International Journal of Cardiology},
pages = {441--445},
title = {Attenuation of reflected waves in man during retrograde propagation from femoral artery to proximal aorta},
url = {http://dx.doi.org/10.1016/j.ijcard.2015.09.064},
volume = {202},
year = {2015}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundWave reflection may be an important influence on blood pressure, but the extent to which reflections undergo attenuation during retrograde propagation has not been studied. We quantified retrograde transmission of a reflected wave created by occlusion of the left femoral artery in man.Methods20 subjects (age 31–83 years; 14 male) underwent invasive measurement of pressure and flow velocity with a sensor-tipped intra-arterial wire at multiple locations distal to the proximal aorta before, during and following occlusion of the left femoral artery by thigh cuff inflation. A numerical model of the circulation was also used to predict reflected wave transmission. Wave reflection was measured as the ratio of backward to forward wave energy (WRI) and the ratio of peak backward to forward pressure (Pb/Pf).ResultsCuff inflation caused a marked reflection which was largest at 5–10 cm from the cuff (change (Δ) in WRI = 0.50 (95% CI 0.38, 0.62); p < 0.001, ΔPb/Pf = 0.23 (0.18–0.29); p < 0.001). The magnitude of the cuff-induced reflection decreased progressively at more proximal locations and was barely discernible at sites > 40 cm from the cuff including in the proximal aorta. Numerical modelling gave similar predictions to those observed experimentally.ConclusionsReflections due to femoral artery occlusion are markedly attenuated by the time they reach the proximal aorta. This is due to impedance mismatches of bifurcations traversed in the backward direction. This degree of attenuation is inconsistent with the idea of a large discrete reflected wave arising from the lower limb and propagating back into the aorta.
AU  - Baksi,AJ
AU  - Davies,JE
AU  - Hadjiloizou,N
AU  - Baruah,R
AU  - Unsworth,B
AU  - Foale,RA
AU  - Korolkova,O
AU  - Siggers,JH
AU  - Francis,DP
AU  - Mayet,J
AU  - Parker,KH
AU  - Hughes,AD
DO  - 10.1016/j.ijcard.2015.09.064
EP  - 445
PY  - 2015///
SN  - 1874-1754
SP  - 441
TI  - Attenuation of reflected waves in man during retrograde propagation from femoral artery to proximal aorta
T2  - International Journal of Cardiology
UR  - http://dx.doi.org/10.1016/j.ijcard.2015.09.064
UR  - http://hdl.handle.net/10044/1/27309
VL  - 202
ER  -
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