Imperial College London
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ProfessorJamilMayet

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 1006j.mayet

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

NHLI offices,Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ghosh:2016:10.1136/heartjnl-2015-308836,
author = {Ghosh, AK and Hughes, AD and Francis, D and Chaturvedi, N and Pellerin, D and Deanfield, J and Kuh, D and Mayet, J and Hardy, R and MRC, NSHD Scientific and Data Collection Team},
doi = {10.1136/heartjnl-2015-308836},
journal = {Heart},
pages = {1380--1387},
title = {Midlife blood pressure predicts future diastolic dysfunction independently of blood pressure.},
url = {http://dx.doi.org/10.1136/heartjnl-2015-308836},
volume = {102},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVES: High blood pressure (BP) is associated with diastolic dysfunction, but the consequence of elevated BP over the adult life course on diastolic function is unknown. We hypothesised that high BP in earlier adulthood would be associated with impaired diastolic function independent of current BP. METHODS: Participants in the Medical Research Council National Survey of Health and Development birth cohort (n=1653) underwent investigations including echocardiography at age 60-64years. The relationships between adult BP, antihypertensive treatment (HTT) and echocardiographic measures of diastolic function were assessed using adjusted regression models. RESULTS: Increased systolic BP (SBP) at ages 36, 43 and 53years was predictive of increased E/e' and increased left atrial volume. These effects were only partially explained by SBP at 60-64years and increased left ventricular mass. HTT was also associated with poorer diastolic function after adjustment for SBP at 60-64years. Faster rates of increase in SBP in midlife were also associated with increased poorer diastolic function. CONCLUSIONS: High SBP in midlife is associated with poorer diastolic function at age 60-64years. Early identification of individuals with high BP or rapid rises in BP may be important for prevention of impaired cardiac function in later life.
AU  - Ghosh,AK
AU  - Hughes,AD
AU  - Francis,D
AU  - Chaturvedi,N
AU  - Pellerin,D
AU  - Deanfield,J
AU  - Kuh,D
AU  - Mayet,J
AU  - Hardy,R
AU  - MRC,NSHD Scientific and Data Collection Team
DO  - 10.1136/heartjnl-2015-308836
EP  - 1387
PY  - 2016///
SN  - 1355-6037
SP  - 1380
TI  - Midlife blood pressure predicts future diastolic dysfunction independently of blood pressure.
T2  - Heart
UR  - http://dx.doi.org/10.1136/heartjnl-2015-308836
UR  - http://hdl.handle.net/10044/1/37506
VL  - 102
ER  -
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